FUNCTION, SUBCELLULAR LOCATION, DOMAIN REGION A, INTERACTION WITH THE CCR4-NOT COMPLEX, INTERACTION WITH DCP1A; DCP2; DDX6; EDC3; EDC4; LSM1; LSM4 AND XRN1
Categories
Function, Family & Domains, Interaction, Subcellular Location
X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF 517-767, RNA-BINDING, FUNCTION, SUBCELLULAR LOCATION, DOMAIN REGION C, INTERACTION WITH THE LSM-CONTAINING SMN-SM PROTEIN COMPLEX, INTERACTION WITH DCP2; DDX6 AND EDC4, MUTAGENESIS OF ARG-519; ARG-520; LEU-523; GLU-527; TYR-530; LEU-534; 539-TYR--ASP-557; ARG-591; ARG-595; LYS-625 AND LYS-626
Another decapping activator PatL1 directly interacts with CIR and alleviates the CIR-mediated inhibition of CCR4-NOT activity in vitro. Ribosome profiling revealed that XRN1 loss impacts not only on mRNA levels but also on the translational efficiency of many cellular transcripts likely as a consequence of incomplete decay
data indicate that P-body assembly occurs in a step-wise manner where Rck participates in the initial suppression of mRNA translation whereas Pat1b in a second step triggers P-body assembly and promotes mRNA decapping
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