Q86NH1 · SYD1_CAEEL
- ProteinRho GTPase-activating protein syd-1
- Genesyd-1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids987 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Probable GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Regulates the localization and assembly of presynaptic components during presynaptic development and is required for specifying the identity of axons during initial polarity acquisition. In these roles it is thought to act cell autonomously downstream of syg-1 and syg-2 and upstream of syd-2, possibly as a positive regulator of the latter. Required for the control of movement, egg-laying and the correct localization of elks-1.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | neuron projection | |
Cellular Component | presynaptic membrane | |
Cellular Component | synapse | |
Cellular Component | synaptic membrane | |
Molecular Function | GTPase activator activity | |
Molecular Function | Roundabout binding | |
Molecular Function | signaling receptor binding | |
Molecular Function | small GTPase binding | |
Biological Process | activation of GTPase activity | |
Biological Process | axo-dendritic transport | |
Biological Process | cell differentiation | |
Biological Process | cell migration | |
Biological Process | cell projection organization | |
Biological Process | locomotion | |
Biological Process | nervous system development | |
Biological Process | protein localization | |
Biological Process | regulation of Ras protein signal transduction | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRho GTPase-activating protein syd-1
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionQ86NH1
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Worms exhibit an irregular shape and fail to show axonic polarization. Uncoordinated movement and retention of eggs, an egg-laying defect are apparent.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000309560 | 1-987 | Rho GTPase-activating protein syd-1 | |||
Sequence: MLISTSLKFLTMLTSNGFGGTNPPKGMPYPPTYLYTEEPQNECCCCWLCRLLCCCSPVDQTASRSRMNASQPPPGGGGRLPDEVFRKITAVDQGQSTLTQSGIQGLSARTLSSEPRGDLVFQLVEIIKKPGQSLGLYLREGNGKDRSDGVFVSRFGDNSELAKYGEVMRPGDEILTINNVEVSMMSIDDVVLILSIPRRLLLRIRYSKSMRHEIISSRSRESERPVVVFHKYDDRRDSETNAPILSQPTSTANTWLGKKSRQQMEEMRNATTSSTLRTHASTSSPRNHFAPRLVNGHSHSIGVPSASTTSHDHQYQRFASEPSDSVSRTARVPPPRLASATVRRTESFNSAPGVSTSAPMYTLPRSSTAVPPPDILGSIPYSARDPLMRSSADLPYDPMTGRLSSSVPTDPLLSRSLCSPILPRTLRQANDSNKSNSLPRRRIMTGGRNVKWRNDVVSTSDLCGEESDGAISAPEYSSPPFSRLTQQQQFRLSNGSPGRTVNDIFSAAEYRNWAGPYDPRGMYGPFPPGQRATRWSHTYGEQRAPRTSSLPGRTVLAQSLVGSPVLPRHPPPIVQDRPSAVFDRYHVSPLMNRRAPLRAAGPGINVDRLSVSSLTGILYVHIVEGRGLKIPEKQKGLTEEMYCVLEVDEQHRARTGVSTIEQKFKWRETFHIDVVNATVSNFFVYSWHPQFRHKLCHKGSLKLLEAFVVDQLNDDRVFALNLEPRGQLIVRIGFHDLQAVFRRTVNPRLNGVFGISLSRLVQRERRDTPIVLTRLIQEIEKRGVDYSGLYVLCGSVEKKKMLRAELESNPLGTELAAESIPDTNVIACLIKDFLRELPEPLISPQIHGMLLEAASVALPNDVQTNRHLVLKIIDCLQLSAKNCLLLVLDHLSTVLCSSPHNGLTPTRLSLIFAPLLFFCLDTFSPYTISPTSKMAAVRTLDINQASSSLQMILSIWPSRVNSESGSDSPATTCQKGGVIAYVSESQC |
Proteomic databases
Expression
Tissue specificity
Expressed in the nerve ring of embryos. In L1 larvae, expression is seen in the ventral processes of ventral cord motor neurons. In adults, expression is seen along the dorsal and ventral nerve cords, the HSNL motor neuron and more specifically localizes to the axonal processes.
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 123-209 | PDZ | ||||
Sequence: LVEIIKKPGQSLGLYLREGNGKDRSDGVFVSRFGDNSELAKYGEVMRPGDEILTINNVEVSMMSIDDVVLILSIPRRLLLRIRYSKS | ||||||
Compositional bias | 266-289 | Polar residues | ||||
Sequence: EMRNATTSSTLRTHASTSSPRNHF | ||||||
Region | 266-334 | Disordered | ||||
Sequence: EMRNATTSSTLRTHASTSSPRNHFAPRLVNGHSHSIGVPSASTTSHDHQYQRFASEPSDSVSRTARVPP | ||||||
Compositional bias | 300-327 | Polar residues | ||||
Sequence: SIGVPSASTTSHDHQYQRFASEPSDSVS | ||||||
Compositional bias | 348-364 | Polar residues | ||||
Sequence: FNSAPGVSTSAPMYTLP | ||||||
Region | 348-369 | Disordered | ||||
Sequence: FNSAPGVSTSAPMYTLPRSSTA | ||||||
Compositional bias | 424-442 | Polar residues | ||||
Sequence: RTLRQANDSNKSNSLPRRR | ||||||
Region | 424-446 | Disordered | ||||
Sequence: RTLRQANDSNKSNSLPRRRIMTG | ||||||
Region | 463-497 | Disordered | ||||
Sequence: CGEESDGAISAPEYSSPPFSRLTQQQQFRLSNGSP | ||||||
Compositional bias | 478-497 | Polar residues | ||||
Sequence: SPPFSRLTQQQQFRLSNGSP | ||||||
Domain | 598-722 | C2 | ||||
Sequence: RAAGPGINVDRLSVSSLTGILYVHIVEGRGLKIPEKQKGLTEEMYCVLEVDEQHRARTGVSTIEQKFKWRETFHIDVVNATVSNFFVYSWHPQFRHKLCHKGSLKLLEAFVVDQLNDDRVFALNL | ||||||
Domain | 755-949 | Rho-GAP | ||||
Sequence: ISLSRLVQRERRDTPIVLTRLIQEIEKRGVDYSGLYVLCGSVEKKKMLRAELESNPLGTELAAESIPDTNVIACLIKDFLRELPEPLISPQIHGMLLEAASVALPNDVQTNRHLVLKIIDCLQLSAKNCLLLVLDHLSTVLCSSPHNGLTPTRLSLIFAPLLFFCLDTFSPYTISPTSKMAAVRTLDINQASSSL |
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q86NH1-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Namea
- Length987
- Mass (Da)109,299
- Last updated2003-06-01 v1
- Checksum71352844D35C966E
Q86NH1-2
- Nameb
Q86NH1-3
- Namec
- Differences from canonical
- 1-266: Missing
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_052592 | 1-66 | in isoform b | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_052591 | 1-266 | in isoform c | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_052593 | 77-78 | in isoform b | |||
Sequence: Missing | ||||||
Compositional bias | 266-289 | Polar residues | ||||
Sequence: EMRNATTSSTLRTHASTSSPRNHF | ||||||
Compositional bias | 300-327 | Polar residues | ||||
Sequence: SIGVPSASTTSHDHQYQRFASEPSDSVS | ||||||
Compositional bias | 348-364 | Polar residues | ||||
Sequence: FNSAPGVSTSAPMYTLP | ||||||
Compositional bias | 424-442 | Polar residues | ||||
Sequence: RTLRQANDSNKSNSLPRRR | ||||||
Compositional bias | 478-497 | Polar residues | ||||
Sequence: SPPFSRLTQQQQFRLSNGSP | ||||||
Alternative sequence | VSP_052594 | 961 | in isoform b | |||
Sequence: N → SELVEFFPFLLNYPTVSYSSPNPH |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF546880 EMBL· GenBank· DDBJ | AAN38752.1 EMBL· GenBank· DDBJ | mRNA | ||
FO081290 EMBL· GenBank· DDBJ | CCD70505.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FO081290 EMBL· GenBank· DDBJ | CCD70506.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FO081290 EMBL· GenBank· DDBJ | CCD70507.1 EMBL· GenBank· DDBJ | Genomic DNA |