Q86MD3 · ATF7_CAEEL

  • Protein
    Transcription factor atf-7
  • Gene
    atf-7
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Transcription factor which regulates the transcription of various genes, including those involved in innate immunity and oxidative stress responses (PubMed:20369020, PubMed:28632756, PubMed:30789901).
Binds to promoter regions of genes, probably at 5'-[GACGTCA]-3' consensus sequences (PubMed:30789901).
Together with transcription factor daf-19, involved in regulation of the serotonergic response of ADF neurons to pathogenic food (PubMed:23505381).
Modulates response to infection by the Gram-negative bacterium P.aeruginosa, acting downstream of the p38 signal transduction pathway effector serine/threonine kinase pmk-1 (PubMed:20369020, PubMed:30789901).
May act with transcription factor elt-2 to control p38 gene induction in response to bacterial infection (PubMed:26016853).
May be phosphorylated by pmk-1 (PubMed:20369020).
Regulates transcription of the metallothionein gene, mtl-1, perhaps acting downstream of pmk-1 (PubMed:28632756).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromatin
Cellular Componentnucleus
Molecular FunctioncAMP response element binding
Molecular FunctionDNA-binding transcription factor activity
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Functionmitogen-activated protein kinase binding
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processcellular response to metal ion
Biological Processcellular response to reactive oxygen species
Biological Processdefense response to Gram-negative bacterium
Biological Processnegative regulation of innate immune response
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processpositive regulation of innate immune response
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processregulation of gene expression
Biological Processregulation of transcription by RNA polymerase II
Biological Processserotonin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Transcription factor atf-7
  • Alternative names
    • cAMP-dependent transcription factor family member 7

Gene names

    • Name
      atf-7
    • ORF names
      C07G2.2

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    Q86MD3
  • Secondary accessions
    • B3GWA6
    • Q17801
    • Q9U3R1

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

RNAi-mediated knockdown increases susceptibility to infection by the Gram-negative bacterium P.aeruginosa (PubMed:20369020).
Up-regulates expression of metallothionein mtl-1 (PubMed:28632756).

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis107In qd22; increases level of activated MAP kinase pmk-1 compared to wild-type. Simultaneous RNA-imediated knockdown of atf-7 confers increased resistance to Gram-negative bacterium P.aeruginosa.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004526931-509Transcription factor atf-7

Proteomic databases

Expression

Tissue specificity

Expressed in intestinal cells.

Gene expression databases

Interaction

Subunit

Interacts with serine/threonine kinase pmk-1; perhaps in a manner dependent on dual specificity protein kinase sek-1.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias283-307Polar residues
Region283-318Disordered
Compositional bias337-369Polar residues
Region337-400Disordered
Compositional bias385-400Basic and acidic residues
Domain391-464bZIP
Region393-413Basic motif
Region419-450Leucine-zipper

Sequence similarities

Belongs to the bZIP family.

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete

This entry describes 4 isoforms produced by Alternative splicing.

Q86MD3-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    509
  • Mass (Da)
    54,727
  • Last updated
    2003-06-01 v1
  • Checksum
    7CD869FAB173950D
MATTMMTSSASPPESGELDVASAVASAAAALISPMVMPTSMTNGKDMTKTSQILNEYFNMMVGKRVQLMGDTTSPFSLDTPNPKLMFTPLDLPTTAELMQRCLAVNPFEAKFREANQKISSGSMQPNTSGANQSLEALEANGGSQFSGSNAGTMSDLLLKIPQASLQHSPGIFSNMLLNAGDSEGTTRENLKTADISKLLSVAGDFSAQAPRTADVLNAVLDMHSDRLHTINYLNNKPDFSALLRSPSSSAPNSASVLTNAMAIPSTSGAPFPGTTLLVPPKTVSSYHSPLGASSQPPSTQKSPADGSWDHINGEKQIKKEIPYFNDDAMMLMERSNMSSSGSDQDQSADMSNAGSTASTSTGNPVGRPQNGTPGRGRGRGRSTTADMQPDERRNTILERNKAAAVRYRKRKKEEHDDMMGRVQAMEAEKNQLLAIQTQNQVLRRELERVTALLTERESRCVCLKGVPMSDEQHADHHHRNTNGMYSGSDMLNGLGQINGMQLKLPKLQ

Q86MD3-2

  • Name
    b
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-63: MATTMMTSSASPPESGELDVASAVASAAAALISPMVMPTSMTNGKDMTKTSQILNEYFNMMVG → MSVVTTTSMQSDSK

Q86MD3-3

  • Name
    a
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-63: MATTMMTSSASPPESGELDVASAVASAAAALISPMVMPTSMTNGKDMTKTSQILNEYFNMMVG → MSVVTTTSMQSDSK
    • 435-437: Missing

Q86MD3-4

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0610391-63in isoform b and isoform a
Alternative sequenceVSP_0610381-68in isoform d
Compositional bias283-307Polar residues
Compositional bias337-369Polar residues
Compositional bias385-400Basic and acidic residues
Alternative sequenceVSP_061041435-437in isoform a
Alternative sequenceVSP_061040435-441in isoform d
Alternative sequenceVSP_061042442-509in isoform d

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX284603
EMBL· GenBank· DDBJ
CAA83680.1
EMBL· GenBank· DDBJ
Genomic DNA
BX284603
EMBL· GenBank· DDBJ
CAB63430.2
EMBL· GenBank· DDBJ
Genomic DNA
BX284603
EMBL· GenBank· DDBJ
CAD88215.1
EMBL· GenBank· DDBJ
Genomic DNA
BX284603
EMBL· GenBank· DDBJ
CAQ58094.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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