Q86MD3 · ATF7_CAEEL
- ProteinTranscription factor atf-7
- Geneatf-7
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids509 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Transcription factor which regulates the transcription of various genes, including those involved in innate immunity and oxidative stress responses (PubMed:20369020, PubMed:28632756, PubMed:30789901).
Binds to promoter regions of genes, probably at 5'-[GACGTCA]-3' consensus sequences (PubMed:30789901).
Together with transcription factor daf-19, involved in regulation of the serotonergic response of ADF neurons to pathogenic food (PubMed:23505381).
Modulates response to infection by the Gram-negative bacterium P.aeruginosa, acting downstream of the p38 signal transduction pathway effector serine/threonine kinase pmk-1 (PubMed:20369020, PubMed:30789901).
May act with transcription factor elt-2 to control p38 gene induction in response to bacterial infection (PubMed:26016853).
May be phosphorylated by pmk-1 (PubMed:20369020).
Regulates transcription of the metallothionein gene, mtl-1, perhaps acting downstream of pmk-1 (PubMed:28632756).
Binds to promoter regions of genes, probably at 5'-[GACGTCA]-3' consensus sequences (PubMed:30789901).
Together with transcription factor daf-19, involved in regulation of the serotonergic response of ADF neurons to pathogenic food (PubMed:23505381).
Modulates response to infection by the Gram-negative bacterium P.aeruginosa, acting downstream of the p38 signal transduction pathway effector serine/threonine kinase pmk-1 (PubMed:20369020, PubMed:30789901).
May act with transcription factor elt-2 to control p38 gene induction in response to bacterial infection (PubMed:26016853).
May be phosphorylated by pmk-1 (PubMed:20369020).
Regulates transcription of the metallothionein gene, mtl-1, perhaps acting downstream of pmk-1 (PubMed:28632756).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTranscription factor atf-7
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionQ86MD3
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
RNAi-mediated knockdown increases susceptibility to infection by the Gram-negative bacterium P.aeruginosa (PubMed:20369020).
Up-regulates expression of metallothionein mtl-1 (PubMed:28632756).
Up-regulates expression of metallothionein mtl-1 (PubMed:28632756).
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 107 | In qd22; increases level of activated MAP kinase pmk-1 compared to wild-type. Simultaneous RNA-imediated knockdown of atf-7 confers increased resistance to Gram-negative bacterium P.aeruginosa. | ||||
Sequence: P → S |
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000452693 | 1-509 | Transcription factor atf-7 | |||
Sequence: MATTMMTSSASPPESGELDVASAVASAAAALISPMVMPTSMTNGKDMTKTSQILNEYFNMMVGKRVQLMGDTTSPFSLDTPNPKLMFTPLDLPTTAELMQRCLAVNPFEAKFREANQKISSGSMQPNTSGANQSLEALEANGGSQFSGSNAGTMSDLLLKIPQASLQHSPGIFSNMLLNAGDSEGTTRENLKTADISKLLSVAGDFSAQAPRTADVLNAVLDMHSDRLHTINYLNNKPDFSALLRSPSSSAPNSASVLTNAMAIPSTSGAPFPGTTLLVPPKTVSSYHSPLGASSQPPSTQKSPADGSWDHINGEKQIKKEIPYFNDDAMMLMERSNMSSSGSDQDQSADMSNAGSTASTSTGNPVGRPQNGTPGRGRGRGRSTTADMQPDERRNTILERNKAAAVRYRKRKKEEHDDMMGRVQAMEAEKNQLLAIQTQNQVLRRELERVTALLTERESRCVCLKGVPMSDEQHADHHHRNTNGMYSGSDMLNGLGQINGMQLKLPKLQ |
Proteomic databases
Expression
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 283-307 | Polar residues | ||||
Sequence: TVSSYHSPLGASSQPPSTQKSPADG | ||||||
Region | 283-318 | Disordered | ||||
Sequence: TVSSYHSPLGASSQPPSTQKSPADGSWDHINGEKQI | ||||||
Compositional bias | 337-369 | Polar residues | ||||
Sequence: NMSSSGSDQDQSADMSNAGSTASTSTGNPVGRP | ||||||
Region | 337-400 | Disordered | ||||
Sequence: NMSSSGSDQDQSADMSNAGSTASTSTGNPVGRPQNGTPGRGRGRGRSTTADMQPDERRNTILER | ||||||
Compositional bias | 385-400 | Basic and acidic residues | ||||
Sequence: TADMQPDERRNTILER | ||||||
Domain | 391-464 | bZIP | ||||
Sequence: DERRNTILERNKAAAVRYRKRKKEEHDDMMGRVQAMEAEKNQLLAIQTQNQVLRRELERVTALLTERESRCVCL | ||||||
Region | 393-413 | Basic motif | ||||
Sequence: RRNTILERNKAAAVRYRKRKK | ||||||
Region | 419-450 | Leucine-zipper | ||||
Sequence: MMGRVQAMEAEKNQLLAIQTQNQVLRRELERV |
Sequence similarities
Belongs to the bZIP family.
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 4 isoforms produced by Alternative splicing.
Q86MD3-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Namec
- Length509
- Mass (Da)54,727
- Last updated2003-06-01 v1
- Checksum7CD869FAB173950D
Q86MD3-2
- Nameb
- Differences from canonical
- 1-63: MATTMMTSSASPPESGELDVASAVASAAAALISPMVMPTSMTNGKDMTKTSQILNEYFNMMVG → MSVVTTTSMQSDSK
Q86MD3-3
- Namea
Q86MD3-4
- Named
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_061039 | 1-63 | in isoform b and isoform a | |||
Sequence: MATTMMTSSASPPESGELDVASAVASAAAALISPMVMPTSMTNGKDMTKTSQILNEYFNMMVG → MSVVTTTSMQSDSK | ||||||
Alternative sequence | VSP_061038 | 1-68 | in isoform d | |||
Sequence: Missing | ||||||
Compositional bias | 283-307 | Polar residues | ||||
Sequence: TVSSYHSPLGASSQPPSTQKSPADG | ||||||
Compositional bias | 337-369 | Polar residues | ||||
Sequence: NMSSSGSDQDQSADMSNAGSTASTSTGNPVGRP | ||||||
Compositional bias | 385-400 | Basic and acidic residues | ||||
Sequence: TADMQPDERRNTILER | ||||||
Alternative sequence | VSP_061041 | 435-437 | in isoform a | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_061040 | 435-441 | in isoform d | |||
Sequence: AIQTQNQ → VRNEILY | ||||||
Alternative sequence | VSP_061042 | 442-509 | in isoform d | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX284603 EMBL· GenBank· DDBJ | CAA83680.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX284603 EMBL· GenBank· DDBJ | CAB63430.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX284603 EMBL· GenBank· DDBJ | CAD88215.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX284603 EMBL· GenBank· DDBJ | CAQ58094.1 EMBL· GenBank· DDBJ | Genomic DNA |