Q86KR9 · P4HA_DICDI

Function

function

Catalyzes the post-translational formation of 4-hydroxyproline. Probably hydroxylates skp1 on Pro-143.

Cofactor

Protein has several cofactor binding sites:
Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Note: Binds 1 Fe2+ ion per subunit.
L-ascorbate (UniProtKB | Rhea| CHEBI:38290 )

Activity regulation

Inhibited by the prolyl-hydroxylase inhibitors alpha,alpha'-dipyridyl and ethyl 3,4-dihydroxybenzoate.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site191Fe cation (UniProtKB | ChEBI)
Binding site193Fe cation (UniProtKB | ChEBI)
Binding site266Fe cation (UniProtKB | ChEBI)
Binding site2762-oxoglutarate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionferrous iron binding
Molecular FunctionL-ascorbic acid binding
Molecular Functionpeptidyl-proline 4-dioxygenase activity
Molecular Functionpeptidyl-proline dioxygenase activity
Biological Processcellular response to hypoxia
Biological Processculmination involved in sorocarp development
Biological Processoxygen metabolic process
Biological ProcessSCF complex assembly

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Prolyl 4-hydroxylase subunit alpha
  • EC number
  • Short names
    Prolyl 4-hydrolase

Gene names

    • Name
      phyA
    • Synonyms
      p4h1
    • ORF names
      DDB_G0277759

Organism names

Accessions

  • Primary accession
    Q86KR9
  • Secondary accessions
    • Q54Z57

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003275771-284Prolyl 4-hydroxylase subunit alpha

Proteomic databases

Interaction

Subunit

Heterotetramer of two alpha-1 chains and two beta chains (the beta chain is the multi-functional PDI).

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain169-284Fe2OG dioxygenase

Sequence similarities

Belongs to the P4HA family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    284
  • Mass (Da)
    33,348
  • Last updated
    2003-06-01 v1
  • Checksum
    19AE1D748793D0E3
MDISNLPPHIRQQILGLISKPQQNNDESSSSNNKNNLINNEKVSNVLIDLTSNLKIENFKIFNKESLNQLEKKGYLIIDNFLNDLNKINLIYDESYNQFKENKLIEAGMNKGTDKWKDKSIRGDYIQWIHRDSNSRIQDKDLSSTIRNINYLLDKLDLIKNEFDNVIPNFNSIKTQTQLAVYLNGGRYIKHRDSFYSSESLTISRRITMIYYVNKDWKKGDGGELRLYTNNPNNTNQKELKQTEEFIDIEPIADRLLIFLSPFLEHEVLQCNFEPRIAITTWIY

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY768817
EMBL· GenBank· DDBJ
AAV37458.1
EMBL· GenBank· DDBJ
Genomic DNA
AAFI02000022
EMBL· GenBank· DDBJ
EAL68553.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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