Q86K32 · UBE2N_DICDI
- ProteinProbable ubiquitin-conjugating enzyme E2 N
- Geneube2n
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids154 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
The ube2v/ube2n heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
Catalytic activity
Pathway
Protein modification; protein ubiquitination.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 87 | Glycyl thioester intermediate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | ubiquitin conjugating enzyme activity | |
Biological Process | postreplication repair | |
Biological Process | protein K63-linked ubiquitination |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProbable ubiquitin-conjugating enzyme E2 N
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Amoebozoa > Evosea > Eumycetozoa > Dictyostelia > Dictyosteliales > Dictyosteliaceae > Dictyostelium
Accessions
- Primary accessionQ86K32
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000328343 | 1-154 | Probable ubiquitin-conjugating enzyme E2 N | ||
Proteomic databases
Interaction
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length154
- Mass (Da)17,380
- Last updated2010-01-19 v2
- MD5 Checksum83896B16215060A855CF0FFD84561B8D
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAFI02000019 EMBL· GenBank· DDBJ | EAL68819.2 EMBL· GenBank· DDBJ | Genomic DNA |