Q86JF2 · LVSB_DICDI

Function

function

Involved in negative regulation of lysosome biogenesis, by limiting the heterotypic fusion of early endosomes and postlysosomal compartments.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentendosome
Cellular Componentlysosome
Cellular Componentmembrane
Cellular Componentphagocytic vesicle
Cellular Componentphagolysosome
Molecular Functionprotein kinase binding
Biological Processcellular response to starvation
Biological Processculmination involved in sorocarp development
Biological Processexocytosis
Biological Processlysosomal lumen acidification
Biological Processlysosomal transport
Biological Processlysosome organization
Biological Processnegative regulation of endosomal vesicle fusion
Biological Processphagolysosome assembly
Biological Processprotein localization
Biological Processprotein secretion
Biological Processregulation of vesicle size
Biological Processresponse to osmotic stress

Names & Taxonomy

Protein names

  • Recommended name
    BEACH domain-containing protein lvsB

Gene names

    • Name
      lvsB
    • ORF names
      DDB_G0271504

Organism names

Accessions

  • Primary accession
    Q86JF2
  • Secondary accessions
    • Q55AT1
    • Q8IHL0

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Multi-pass membrane protein
Lysosome
Endosome
Note: Also found in post-lysosome.

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane198-218Helical
Transmembrane827-847Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003277081-4118BEACH domain-containing protein lvsB

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

3D structure databases

Family & Domains

Features

Showing features for region, compositional bias, coiled coil, domain, repeat.

Type
IDPosition(s)Description
Region1-35Disordered
Compositional bias236-258Polar residues
Region236-267Disordered
Region332-382Disordered
Region621-644Disordered
Compositional bias1155-1189Polar residues
Region1155-1213Disordered
Compositional bias1190-1204Basic and acidic residues
Region1599-1622Disordered
Region1643-1681Disordered
Region1928-1968Disordered
Region2015-2044Disordered
Compositional bias2537-2573Polar residues
Region2537-2574Disordered
Region2702-2741Disordered
Compositional bias2704-2737Basic and acidic residues
Coiled coil2705-2738
Region2754-2791Disordered
Region2902-3007Disordered
Region3245-3265Disordered
Domain3303-3479BEACH-type PH
Compositional bias3348-3417Polar residues
Region3348-3418Disordered
Domain3491-3782BEACH
Repeat3868-3907WD 1
Repeat3924-3963WD 2
Repeat3984-4027WD 3
Repeat4029-4073WD 4
Repeat4075-4114WD 5

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    4,118
  • Mass (Da)
    463,997
  • Last updated
    2003-06-01 v1
  • MD5 Checksum
    E3F3230998CAD5CDDD2EE6A4AF9941F1

Sequence caution

The sequence AAN38985.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for compositional bias, sequence conflict.

Type
IDPosition(s)Description
Compositional bias236-258Polar residues
Compositional bias1155-1189Polar residues
Compositional bias1190-1204Basic and acidic residues
Sequence conflict2030in Ref. 3; AAN38985
Compositional bias2537-2573Polar residues
Compositional bias2704-2737Basic and acidic residues
Compositional bias3348-3417Polar residues
Sequence conflict4104in Ref. 3; AAN38985

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAFI02000006
EMBL· GenBank· DDBJ
EAL71616.2
EMBL· GenBank· DDBJ
Genomic DNA
AY159038
EMBL· GenBank· DDBJ
AAN38985.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.

Genome annotation databases

Similar Proteins

Disclaimer

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