Q86JF2 · LVSB_DICDI
- ProteinBEACH domain-containing protein lvsB
- GenelvsB
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids4118 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
function
Involved in negative regulation of lysosome biogenesis, by limiting the heterotypic fusion of early endosomes and postlysosomal compartments.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | endosome | |
Cellular Component | lysosome | |
Cellular Component | membrane | |
Cellular Component | phagocytic vesicle | |
Cellular Component | phagolysosome | |
Molecular Function | protein kinase binding | |
Biological Process | cellular response to starvation | |
Biological Process | culmination involved in sorocarp development | |
Biological Process | exocytosis | |
Biological Process | lysosomal lumen acidification | |
Biological Process | lysosomal transport | |
Biological Process | lysosome organization | |
Biological Process | negative regulation of endosomal vesicle fusion | |
Biological Process | phagolysosome assembly | |
Biological Process | protein localization | |
Biological Process | protein secretion | |
Biological Process | regulation of vesicle size | |
Biological Process | response to osmotic stress |
Names & Taxonomy
Protein names
- Recommended nameBEACH domain-containing protein lvsB
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Amoebozoa > Evosea > Eumycetozoa > Dictyostelia > Dictyosteliales > Dictyosteliaceae > Dictyostelium
Accessions
- Primary accessionQ86JF2
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000327708 | 1-4118 | BEACH domain-containing protein lvsB | ||
Proteomic databases
Interaction
Protein-protein interaction databases
Family & Domains
Features
Showing features for region, compositional bias, coiled coil, domain, repeat.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-35 | Disordered | |||
Compositional bias | 236-258 | Polar residues | |||
Region | 236-267 | Disordered | |||
Region | 332-382 | Disordered | |||
Region | 621-644 | Disordered | |||
Compositional bias | 1155-1189 | Polar residues | |||
Region | 1155-1213 | Disordered | |||
Compositional bias | 1190-1204 | Basic and acidic residues | |||
Region | 1599-1622 | Disordered | |||
Region | 1643-1681 | Disordered | |||
Region | 1928-1968 | Disordered | |||
Region | 2015-2044 | Disordered | |||
Compositional bias | 2537-2573 | Polar residues | |||
Region | 2537-2574 | Disordered | |||
Region | 2702-2741 | Disordered | |||
Compositional bias | 2704-2737 | Basic and acidic residues | |||
Coiled coil | 2705-2738 | ||||
Region | 2754-2791 | Disordered | |||
Region | 2902-3007 | Disordered | |||
Region | 3245-3265 | Disordered | |||
Domain | 3303-3479 | BEACH-type PH | |||
Compositional bias | 3348-3417 | Polar residues | |||
Region | 3348-3418 | Disordered | |||
Domain | 3491-3782 | BEACH | |||
Repeat | 3868-3907 | WD 1 | |||
Repeat | 3924-3963 | WD 2 | |||
Repeat | 3984-4027 | WD 3 | |||
Repeat | 4029-4073 | WD 4 | |||
Repeat | 4075-4114 | WD 5 | |||
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length4,118
- Mass (Da)463,997
- Last updated2003-06-01 v1
- MD5 ChecksumE3F3230998CAD5CDDD2EE6A4AF9941F1
Sequence caution
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 236-258 | Polar residues | |||
Compositional bias | 1155-1189 | Polar residues | |||
Compositional bias | 1190-1204 | Basic and acidic residues | |||
Sequence conflict | 2030 | in Ref. 3; AAN38985 | |||
Compositional bias | 2537-2573 | Polar residues | |||
Compositional bias | 2704-2737 | Basic and acidic residues | |||
Compositional bias | 3348-3417 | Polar residues | |||
Sequence conflict | 4104 | in Ref. 3; AAN38985 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAFI02000006 EMBL· GenBank· DDBJ | EAL71616.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY159038 EMBL· GenBank· DDBJ | AAN38985.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. |