Q86I81 · MCFI_DICDI
- ProteinMitochondrial substrate carrier family protein I
- GenemcfI
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids338 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Transports folate across the inner membranes of mitochondria (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | mitochondrion | |
Molecular Function | FAD transmembrane transporter activity | |
Molecular Function | folic acid transmembrane transporter activity | |
Biological Process | folate import into mitochondrion |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameMitochondrial substrate carrier family protein I
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Amoebozoa > Evosea > Eumycetozoa > Dictyostelia > Dictyosteliales > Dictyosteliaceae > Dictyostelium
Accessions
- Primary accessionQ86I81
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-24 | Mitochondrial intermembrane | ||||
Sequence: MVNGEEYVETPNLIHDEETRKDVK | ||||||
Transmembrane | 25-45 | Helical; Name=1 | ||||
Sequence: FNLGIELLAGTLAGVSSCILF | ||||||
Topological domain | 46-109 | Mitochondrial matrix | ||||
Sequence: YPLECVEAKLQVQSSSTAVAATMLGLKKNGGSGSGSSSSSSISHQTPNGPIAMAKSILRNEGFK | ||||||
Transmembrane | 110-130 | Helical; Name=2 | ||||
Sequence: GFYQGVSPTILGNAVNWGVYF | ||||||
Topological domain | 131-158 | Mitochondrial intermembrane | ||||
Sequence: SIYRATNHWWNSTDINGNQYQGPAWVGH | ||||||
Transmembrane | 159-179 | Helical; Name=3 | ||||
Sequence: SVSAITAGVITTAIVNPFWVL | ||||||
Topological domain | 180-203 | Mitochondrial matrix | ||||
Sequence: KIRLATSKKYSGMKHAFQSILRSE | ||||||
Transmembrane | 204-224 | Helical; Name=4 | ||||
Sequence: GVGGFWKGVGVSFIGVSEGLF | ||||||
Topological domain | 225-253 | Mitochondrial intermembrane | ||||
Sequence: QFVSYEYILNQMKESNLKMNGGELSVGNY | ||||||
Transmembrane | 254-274 | Helical; Name=5 | ||||
Sequence: LFAGGTARLIAGVLTYPYLLI | ||||||
Topological domain | 275-307 | Mitochondrial matrix | ||||
Sequence: RSSLQSETCPYKSMSEAVKGIYKTNGIKGFYKG | ||||||
Transmembrane | 308-328 | Helical; Name=6 | ||||
Sequence: IGPNLARSIPPAAFMLYIVEF | ||||||
Topological domain | 329-338 | Mitochondrial intermembrane | ||||
Sequence: FRDTLTNFSQ |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000385523 | 1-338 | Mitochondrial substrate carrier family protein I | |||
Sequence: MVNGEEYVETPNLIHDEETRKDVKFNLGIELLAGTLAGVSSCILFYPLECVEAKLQVQSSSTAVAATMLGLKKNGGSGSGSSSSSSISHQTPNGPIAMAKSILRNEGFKGFYQGVSPTILGNAVNWGVYFSIYRATNHWWNSTDINGNQYQGPAWVGHSVSAITAGVITTAIVNPFWVLKIRLATSKKYSGMKHAFQSILRSEGVGGFWKGVGVSFIGVSEGLFQFVSYEYILNQMKESNLKMNGGELSVGNYLFAGGTARLIAGVLTYPYLLIRSSLQSETCPYKSMSEAVKGIYKTNGIKGFYKGIGPNLARSIPPAAFMLYIVEFFRDTLTNFSQ |
Proteomic databases
Expression
Induction
Regulated by the MADS-box transcription factor srfA during development.
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 25-139 | Solcar 1 | ||||
Sequence: FNLGIELLAGTLAGVSSCILFYPLECVEAKLQVQSSSTAVAATMLGLKKNGGSGSGSSSSSSISHQTPNGPIAMAKSILRNEGFKGFYQGVSPTILGNAVNWGVYFSIYRATNHW | ||||||
Repeat | 153-235 | Solcar 2 | ||||
Sequence: PAWVGHSVSAITAGVITTAIVNPFWVLKIRLATSKKYSGMKHAFQSILRSEGVGGFWKGVGVSFIGVSEGLFQFVSYEYILNQ | ||||||
Repeat | 248-332 | Solcar 3 | ||||
Sequence: LSVGNYLFAGGTARLIAGVLTYPYLLIRSSLQSETCPYKSMSEAVKGIYKTNGIKGFYKGIGPNLARSIPPAAFMLYIVEFFRDT |
Sequence similarities
Belongs to the mitochondrial carrier (TC 2.A.29) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length338
- Mass (Da)36,655
- Last updated2003-06-01 v1
- ChecksumE58779BDF7546CA4
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY392437 EMBL· GenBank· DDBJ | AAQ98878.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAFI02000007 EMBL· GenBank· DDBJ | EAL71485.1 EMBL· GenBank· DDBJ | Genomic DNA |