Q86C65 · TOR_DICDI
- ProteinSerine/threonine-protein kinase tor
- Genetor
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids2380 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Regulates cell growth, chemotaxis, signal relay and the actin cytoskeleton. Functions as a part of 2 distinct protein complexes TORC1 and TORC2. TORC1 is a rapamycin-sensitive complex that controls cell growth in response to nutrients and growth factors. The second TOR complex, TORC2, is presumed to be indirectly negatively modulated by rapamycin and regulates actin polarization. TORC2 but not TORC1 negatively regulates phagocytosis. TORC2-dependent regulation of the cytoskeleton may follow differential phosphorylation of pkbA. May have some protein kinase activity, as it appears to phosphorylate pkgB.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Cellular Component | plasma membrane | |
Cellular Component | TORC1 complex | |
Cellular Component | TORC2 complex | |
Molecular Function | ATP binding | |
Molecular Function | protein serine kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Molecular Function | protein-containing complex binding | |
Biological Process | chemotaxis | |
Biological Process | negative regulation of macroautophagy | |
Biological Process | regulation of asexual reproduction | |
Biological Process | regulation of sorocarp development | |
Biological Process | response to caffeine | |
Biological Process | TORC1 signaling |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine/threonine-protein kinase tor
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Amoebozoa > Evosea > Eumycetozoa > Dictyostelia > Dictyosteliales > Dictyosteliaceae > Dictyostelium
Accessions
- Primary accessionQ86C65
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Phenotypes & Variants
Disruption phenotype
Null cells are lethal due to a growth defect involving TOR protein complex 1, TORC1.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000376000 | 1-2380 | Serine/threonine-protein kinase tor | |||
Sequence: MSQHEQPSIWADALTKLLNDLKSKKEEDRVKASKNLKSYVISQSREMTNENFTKFMNELNNNLIFELVNSSVIPEKIGGIMAIDELIDVDYDENATKITRLANYLRIGLGFNDFTVMLMASKALGRLARSSGTLTAEFVEFEVTRALEWLSGDRIEARRHAAVLVLKELAQNAPTLFYVHASSFVDLIWVALKDPKVAIREGAVEALRACLELISERESRLRLQWYQKIYDEAQKSFKQNGSPESIHGSLITVSELLRNTGDFMLSKFKDICETVLKYKDHRDKLVKKTVLALFPRLAVFCSRDFVLNYFNACMNHLLAALRNQNERPTAFIALGEIAMAVGGSIKPYLDSIVVMIKQGLMTKGKQFCPEVLTCISMLASAVGQSMYPHMQVILPQMIVSSGLTVVLTDALRDLTINLPTLIPNIQYKLLNLISQVLANKPFSEPGAPSPYRKSATPFQGGSIPQLGQNSDVDPQMIALALKTLGSFDFSKHNLLEFVRECVVNYLDDDNIEIRREAAITCAQLMVGTEEPTPTRGHSAVIVGEVLEKLLVVGIADPDPSIRKTVLSSLEARFDHYLAQAENLRSLFIALNDELFEIRELAITVIGRLTIRNPAYVMPSLRKTLIQLLTELEFSGDGRNKEESARLLGHLISASEKLIKPYVEPILKALLPKLRDSNPRVASCVLAALGELSVVGGEEMVQHIDSLLPLIIDTLQDQSSTSKREVALKTLAQLASSTGYVIKPFSKYPMLLDTLLNAIKTERIGSIRREVIKVLGILGSLDPYKHKMNELGKRREDPKANDDKNNNMTNEVITISPSNEDYYPTVALTALMKILRDPSLSSHHTSVIQAVMYIFKSLSLKSIPFLPQIMPPFLHAMNTGEPLFREFLFQQLGSLVSIVKQHIRDYLVNVFALIEKYWNSNLLIPIIKLVEEISSALNDEFKVYLPNLIPQMLNVLHTDRSPKRSPTTKVLRALEVFGTNLDDYLHLVIPAIVKLFEQVDVTTQVRTLAIQTIGRLCKKLNFSDYASRIIHPLARVLDSTESELREETLNTLCALVYQLGSDYAIFIPMVGKVLARREIQSTNYELLISKLLKNQQLMLTPGSGDDGGMGANRFGGDHNGHHLGEDHNNTSTPLDIGVKKLKANEQHLKNAWETSQRSTKEDWGEWIRRFSVELLRESPSPALRSCLSLAQDYHPLVKELFNAGFVSCWTELHEQFQEELVRSLETALLSPNIPPEILQTLLNLAEFMELHEKPLPIDIRTLGALAEKCHAYAKALHYKESEFSQSPSSTIEALISINNQLQQPEAAIGILIYAQKNHSVELKEGWYEKLRRWEDALAAYEKKQKDDPNGGTIENTMGILRCLHALGEWERLSALSSETWKSDINDHTRATIAPLAAAAAWNLVNWDKMDEYVCAMNKDTVEGSFYRAILEVHHDNFTLAHGFIDHARTLVDTELTALLGESYNRAYKVVVRLQQLSELEEIIEYKKCVDSPERRNMIKNTWKTRLRGCQHNVDIWQSILAVHSLVISPHEELDMWLKFVGLCRKGSRLGLAQKTLTMLMGKDPSTTSQFGSVLPNTHPRITFAYIKQLWSAGAKQPAFEKLRTFVQALRDTDDLPLQGRAYLKLGEWQLALGDTLSEASIPHIISSFKAATECDPNWYKAWHSWALINFEVVSHYEQNGGTPEQIGAHLLPAVHSFFKSISLGPDRSLQDTLRLLTLWFKHGAQKEVEAALMQGFNTISIDTWLHVIPQIIARIHAPVLPVRRLLHELIDTIGKEHPQALVYPLTVATKSHSPARLAAAKSLMDKMRKHSATLVDQALPVSQELVRTAILWLEMWYEGLEEASRQYFGDHNPEAMLATLAPLHQILEKGPETTSETSFLQAFGRDLQEALEWSKKYEKTRKEGDLNQAWDLYYQVFRRIYKQLPQMSSLELQYVSPKLLNSNNMELAVPGTYKASENVIRIQSFSQALSVIPSKQRPRKLTIIGSDGLEYTFLLKGHEDLRQDERVMQLFSLVNNLLSANHETAKSHLSIRRFSVIPLSPNSGLIGWVPHSDTLHTLIKDFRDSNKILLSIEHRLMLQMCSDYDNLTLLQKVEVFQYALENSNGLDLHKVLWLKSRNSEVWLDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRHTGHILHIDFGDCFEVAMHRDKYPEKIPFRLTRMLINAMEVSGIEGNFRLTCEAVMNVLRNNKESLMAVLEAFVHDPLINWRLLTPNENNTKHKATNIASNNSTSNSTTKIEGDLNTIDNPINKESPDHEAVAGSLKSSPVHGRQIARNQRVGVDAEQVEAEIVPEALNERALSVINRVNKKLTGRDFSSNETLDVPEQVQKLIDQATSHENLCLSYVGWCPFW |
Proteomic databases
Interaction
Subunit
Part of a complex, TORC1, consisting of tor, raptor and lst8. Part of a complex, TORC2, consisting of tor, lst8, piaA and ripA. Additional proteins, such as 14-3-3 and heat-shock proteins, may also belong to the TORC2 complex.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for coiled coil, repeat, domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 11-38 | |||||
Sequence: ADALTKLLNDLKSKKEEDRVKASKNLKS | ||||||
Repeat | 266-303 | HEAT 1 | ||||
Sequence: SKFKDICETVLKYKDHRDKLVKKTVLALFPRLAVFCSR | ||||||
Repeat | 493-530 | HEAT 2 | ||||
Sequence: NLLEFVRECVVNYLDDDNIEIRREAAITCAQLMVGTEE | ||||||
Repeat | 540-578 | HEAT 3 | ||||
Sequence: VIVGEVLEKLLVVGIADPDPSIRKTVLSSLEARFDHYLA | ||||||
Repeat | 580-614 | HEAT 4 | ||||
Sequence: AENLRSLFIALNDELFEIRELAITVIGRLTIRNPA | ||||||
Repeat | 660-697 | HEAT 5 | ||||
Sequence: PYVEPILKALLPKLRDSNPRVASCVLAALGELSVVGGE | ||||||
Repeat | 701-739 | HEAT 6 | ||||
Sequence: QHIDSLLPLIIDTLQDQSSTSKREVALKTLAQLASSTGY | ||||||
Repeat | 745-783 | HEAT 7 | ||||
Sequence: SKYPMLLDTLLNAIKTERIGSIRREVIKVLGILGSLDPY | ||||||
Repeat | 863-900 | HEAT 8 | ||||
Sequence: PFLPQIMPPFLHAMNTGEPLFREFLFQQLGSLVSIVKQ | ||||||
Repeat | 982-1021 | HEAT 9 | ||||
Sequence: DYLHLVIPAIVKLFEQVDVTTQVRTLAIQTIGRLCKKLNF | ||||||
Repeat | 1023-1060 | HEAT 10 | ||||
Sequence: DYASRIIHPLARVLDSTESELREETLNTLCALVYQLGS | ||||||
Repeat | 1210-1249 | HEAT 11 | ||||
Sequence: ELHEQFQEELVRSLETALLSPNIPPEILQTLLNLAEFMEL | ||||||
Repeat | 1255-1288 | TPR 1 | ||||
Sequence: PIDIRTLGALAEKCHAYAKALHYKESEFSQSPSS | ||||||
Domain | 1260-1790 | FAT | ||||
Sequence: TLGALAEKCHAYAKALHYKESEFSQSPSSTIEALISINNQLQQPEAAIGILIYAQKNHSVELKEGWYEKLRRWEDALAAYEKKQKDDPNGGTIENTMGILRCLHALGEWERLSALSSETWKSDINDHTRATIAPLAAAAAWNLVNWDKMDEYVCAMNKDTVEGSFYRAILEVHHDNFTLAHGFIDHARTLVDTELTALLGESYNRAYKVVVRLQQLSELEEIIEYKKCVDSPERRNMIKNTWKTRLRGCQHNVDIWQSILAVHSLVISPHEELDMWLKFVGLCRKGSRLGLAQKTLTMLMGKDPSTTSQFGSVLPNTHPRITFAYIKQLWSAGAKQPAFEKLRTFVQALRDTDDLPLQGRAYLKLGEWQLALGDTLSEASIPHIISSFKAATECDPNWYKAWHSWALINFEVVSHYEQNGGTPEQIGAHLLPAVHSFFKSISLGPDRSLQDTLRLLTLWFKHGAQKEVEAALMQGFNTISIDTWLHVIPQIIARIHAPVLPVRRLLHELIDTIGKEHPQALVYPLTVATKS | ||||||
Repeat | 1316-1349 | TPR 2 | ||||
Sequence: NHSVELKEGWYEKLRRWEDALAAYEKKQKDDPNG | ||||||
Repeat | 1611-1644 | TPR 3 | ||||
Sequence: TDDLPLQGRAYLKLGEWQLALGDTLSEASIPHII | ||||||
Repeat | 1672-1706 | TPR 4 | ||||
Sequence: VSHYEQNGGTPEQIGAHLLPAVHSFFKSISLGPDR | ||||||
Repeat | 1942-1974 | TPR 5 | ||||
Sequence: NNMELAVPGTYKASENVIRIQSFSQALSVIPSK | ||||||
Domain | 1964-2279 | PI3K/PI4K catalytic | ||||
Sequence: FSQALSVIPSKQRPRKLTIIGSDGLEYTFLLKGHEDLRQDERVMQLFSLVNNLLSANHETAKSHLSIRRFSVIPLSPNSGLIGWVPHSDTLHTLIKDFRDSNKILLSIEHRLMLQMCSDYDNLTLLQKVEVFQYALENSNGLDLHKVLWLKSRNSEVWLDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRHTGHILHIDFGDCFEVAMHRDKYPEKIPFRLTRMLINAMEVSGIEGNFRLTCEAVMNVLRNNKESLMAVLEAFVHDPLINWRLLTPNENNTKHKATNIASNNSTSNSTTKIEGDLNTIDNPIN | ||||||
Region | 1970-1976 | G-loop | ||||
Sequence: VIPSKQR | ||||||
Region | 2143-2151 | Catalytic loop | ||||
Sequence: GLGDRHPSN | ||||||
Region | 2163-2188 | Activation loop | ||||
Sequence: HIDFGDCFEVAMHRDKYPEKIPFRLT | ||||||
Domain | 2348-2380 | FATC | ||||
Sequence: ETLDVPEQVQKLIDQATSHENLCLSYVGWCPFW |
Sequence similarities
Belongs to the PI3/PI4-kinase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,380
- Mass (Da)268,750
- Last updated2003-06-01 v1
- Checksum5E2998128B92711E
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY204354 EMBL· GenBank· DDBJ | AAO43977.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAFI02000042 EMBL· GenBank· DDBJ | EAL66546.1 EMBL· GenBank· DDBJ | Genomic DNA |