Q867X6 · CY24A_DICDI
- ProteinSuperoxide-generating NADPH oxidase light chain subunit
- GenecybA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids118 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | NADPH oxidase complex | |
Molecular Function | heme binding | |
Biological Process | innate immune response | |
Biological Process | sorocarp development | |
Biological Process | superoxide anion generation |
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameSuperoxide-generating NADPH oxidase light chain subunit
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Amoebozoa > Evosea > Eumycetozoa > Dictyostelia > Dictyosteliales > Dictyosteliaceae > Dictyostelium
Accessions
- Primary accessionQ867X6
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: As unassembled monomer may localize to the endoplasmic reticulum.
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 9-29 | Helical | ||||
Sequence: WAAMIGMAACWCLIAGGIMGI | ||||||
Transmembrane | 36-56 | Helical | ||||
Sequence: IAIYSICVGGVLYPLLYPLSF | ||||||
Transmembrane | 62-82 | Helical | ||||
Sequence: AIFHQYYVAAALMAGLSVLCY | ||||||
Transmembrane | 83-103 | Helical | ||||
Sequence: FLVPTMLAAMVMDISAVVFLI |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Prevents formation of fruiting bodies.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000361530 | 1-118 | Superoxide-generating NADPH oxidase light chain subunit | |||
Sequence: MGKFKLGNWAAMIGMAACWCLIAGGIMGIWYERRYIAIYSICVGGVLYPLLYPLSFLGPLKAIFHQYYVAAALMAGLSVLCYFLVPTMLAAMVMDISAVVFLISAIKGERGDFFDKQD |
Proteomic databases
Expression
Developmental stage
Expressed during vegetative stage. Expression decreases during development and disappears from 8 hours.
Interaction
Structure
Family & Domains
Sequence similarities
Belongs to the p22phox family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length118
- Mass (Da)13,008
- Last updated2003-06-01 v1
- Checksum2F07828020A16DBB
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY221170 EMBL· GenBank· DDBJ | AAO62418.1 EMBL· GenBank· DDBJ | mRNA | ||
AY221171 EMBL· GenBank· DDBJ | AAO62419.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAFI02000003 EMBL· GenBank· DDBJ | EAL73183.1 EMBL· GenBank· DDBJ | Genomic DNA |