Q867B2 · CXCR3_CAPHI
- ProteinC-X-C chemokine receptor type 3
- GeneCXCR3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids366 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Probably promotes cell chemotaxis response (By similarity).
Binds to CCL21. Upon activation by PF4, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling (By similarity).
Binds to CCL21. Upon activation by PF4, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameC-X-C chemokine receptor type 3
- Short namesCXC-R3; CXCR-3
- Alternative names
- CD Antigen Name
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Caprinae > Capra
Accessions
- Primary accessionQ867B2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Topological domain | 1-55 | Extracellular | |||
Transmembrane | 56-76 | Helical; Name=1 | |||
Topological domain | 77-88 | Cytoplasmic | |||
Transmembrane | 89-109 | Helical; Name=2 | |||
Topological domain | 110-124 | Extracellular | |||
Transmembrane | 125-145 | Helical; Name=3 | |||
Topological domain | 146-167 | Cytoplasmic | |||
Transmembrane | 168-188 | Helical; Name=4 | |||
Topological domain | 189-221 | Extracellular | |||
Transmembrane | 222-242 | Helical; Name=5 | |||
Topological domain | 243-254 | Cytoplasmic | |||
Transmembrane | 255-275 | Helical; Name=6 | |||
Topological domain | 276-299 | Extracellular | |||
Transmembrane | 300-320 | Helical; Name=7 | |||
Topological domain | 321-366 | Cytoplasmic | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation, modified residue, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000069345 | 1-366 | C-X-C chemokine receptor type 3 | ||
Glycosylation | 22 | N-linked (GlcNAc...) asparagine | |||
Modified residue | 25 | Sulfotyrosine | |||
Modified residue | 27 | Sulfotyrosine | |||
Glycosylation | 30 | N-linked (GlcNAc...) asparagine | |||
Disulfide bond | 122↔201 | ||||
Glycosylation | 197 | N-linked (GlcNAc...) asparagine | |||
Post-translational modification
Sulfation on Tyr-25 and Tyr-27 is essential for CXCL10 binding.
N-glycosylated.
Keywords
- PTM
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Homomer. Forms heteromers with ACKR4 (By similarity).
Interacts with PF4/CXCL4 (By similarity).
Interacts with PF4/CXCL4 (By similarity).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 339-366 | Disordered | |||
Compositional bias | 348-366 | Polar residues | |||
Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusComplete
- Length366
- Mass (Da)40,871
- Last updated2003-06-01 v1
- Checksum222AE9D136E09C0F
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A452EPB6 | A0A452EPB6_CAPHI | CXCR3 | 367 | ||
A0A452EP98 | A0A452EP98_CAPHI | CXCR3 | 364 | ||
A0A452ENE1 | A0A452ENE1_CAPHI | CXCR3 | 363 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 348-366 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB099893 EMBL· GenBank· DDBJ | BAC55184.1 EMBL· GenBank· DDBJ | mRNA |