Q867B2 · CXCR3_CAPHI

  • Protein
    C-X-C chemokine receptor type 3
  • Gene
    CXCR3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Probably promotes cell chemotaxis response (By similarity).
Binds to CCL21. Upon activation by PF4, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentexternal side of plasma membrane
Cellular Componentplasma membrane
Molecular FunctionC-C chemokine binding
Molecular FunctionC-C chemokine receptor activity
Molecular FunctionC-X-C chemokine binding
Molecular FunctionC-X-C chemokine receptor activity
Molecular Functionsignaling receptor activity
Biological Processangiogenesis
Biological Processcalcium-mediated signaling
Biological Processcell chemotaxis
Biological ProcessG protein-coupled receptor signaling pathway
Biological Processimmune response
Biological Processinflammatory response
Biological Processnegative regulation of execution phase of apoptosis
Biological Processpositive regulation of angiogenesis
Biological Processpositive regulation of cell population proliferation
Biological Processpositive regulation of chemotaxis
Biological Processpositive regulation of cytosolic calcium ion concentration
Biological Processpositive regulation of release of sequestered calcium ion into cytosol
Biological Processregulation of leukocyte migration

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    C-X-C chemokine receptor type 3
  • Short names
    CXC-R3; CXCR-3
  • Alternative names
    • Interferon-inducible protein 10 receptor (IP-10 receptor)
  • CD Antigen Name
    • CD183

Gene names

    • Name
      CXCR3

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Caprinae > Capra

Accessions

  • Primary accession
    Q867B2

Proteomes

Subcellular Location

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-55Extracellular
Transmembrane56-76Helical; Name=1
Topological domain77-88Cytoplasmic
Transmembrane89-109Helical; Name=2
Topological domain110-124Extracellular
Transmembrane125-145Helical; Name=3
Topological domain146-167Cytoplasmic
Transmembrane168-188Helical; Name=4
Topological domain189-221Extracellular
Transmembrane222-242Helical; Name=5
Topological domain243-254Cytoplasmic
Transmembrane255-275Helical; Name=6
Topological domain276-299Extracellular
Transmembrane300-320Helical; Name=7
Topological domain321-366Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation, modified residue, disulfide bond.

Type
IDPosition(s)Description
ChainPRO_00000693451-366C-X-C chemokine receptor type 3
Glycosylation22N-linked (GlcNAc...) asparagine
Modified residue25Sulfotyrosine
Modified residue27Sulfotyrosine
Glycosylation30N-linked (GlcNAc...) asparagine
Disulfide bond122↔201
Glycosylation197N-linked (GlcNAc...) asparagine

Post-translational modification

Sulfation on Tyr-25 and Tyr-27 is essential for CXCL10 binding.
N-glycosylated.

Keywords

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Homomer. Forms heteromers with ACKR4 (By similarity).
Interacts with PF4/CXCL4 (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region339-366Disordered
Compositional bias348-366Polar residues

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    366
  • Mass (Da)
    40,871
  • Last updated
    2003-06-01 v1
  • Checksum
    222AE9D136E09C0F
MVPEMSERQEFQASEFAYLLENSSYDYGENETYFCCTSPPCPQDFSLNFDRTFLPVLYSLLFVLGLLGNGVVAVVLLSQRAALSSTDTFLLHLAVADALLVLTLPLWAVDAAIQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLSIVHATQFYRRGPPARVALTCVAVWGLCLLFALPDFIFLSSHHDNRLNATHCQYNFPQEGRTALRVLQLVAGFLLPLLVMAYCYARILTVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDTLMDLGALARNCGRESRVDVAKSVTSGMGYMHCCLNPLLYAFVGVKFRERMWVLLMRLGCPDQRGHQRQPSASRRDSSWSETTEASYSGL

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A452EPB6A0A452EPB6_CAPHICXCR3367
A0A452EP98A0A452EP98_CAPHICXCR3364
A0A452ENE1A0A452ENE1_CAPHICXCR3363

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias348-366Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB099893
EMBL· GenBank· DDBJ
BAC55184.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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