Q85KZ3 · Q85KZ3_HUMAN
- ProteinATP synthase protein 8
- GeneATP8
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial membrane | |
Cellular Component | proton-transporting ATP synthase complex, coupling factor F(o) | |
Molecular Function | proton transmembrane transporter activity | |
Biological Process | proton motive force-driven ATP synthesis |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameATP synthase protein 8
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ85KZ3
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion membrane ; Single-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 12-36 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Structure
Family & Domains
Sequence similarities
Belongs to the ATPase protein 8 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length68
- Mass (Da)8,008
- Last updated2003-06-01 v1
- MD5 ChecksumAFB9F448655E4F4DC0034C571BF7F7FC
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY195756 EMBL· GenBank· DDBJ | AAO88427.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ301794 EMBL· GenBank· DDBJ | ABB91052.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF660993 EMBL· GenBank· DDBJ | ABR58574.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF657494 EMBL· GenBank· DDBJ | ABR96388.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU742148 EMBL· GenBank· DDBJ | ACF03815.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ460561 EMBL· GenBank· DDBJ | ACJ47771.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ493516 EMBL· GenBank· DDBJ | ACJ71045.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ891612 EMBL· GenBank· DDBJ | ACV90380.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU122992 EMBL· GenBank· DDBJ | ACY55300.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM765456 EMBL· GenBank· DDBJ | ADK66468.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM852768 EMBL· GenBank· DDBJ | ADL30054.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ157982 EMBL· GenBank· DDBJ | ADN33602.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ384201 EMBL· GenBank· DDBJ | ADO85110.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ245725 EMBL· GenBank· DDBJ | AEY70870.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ701805 EMBL· GenBank· DDBJ | AFF61427.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX153036 EMBL· GenBank· DDBJ | AFO23645.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC911348 EMBL· GenBank· DDBJ | AGO91268.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF297809 EMBL· GenBank· DDBJ | AGW31737.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF451097 EMBL· GenBank· DDBJ | AGZ67898.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ742714 EMBL· GenBank· DDBJ | AIG22785.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ801471 EMBL· GenBank· DDBJ | AIL91985.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM101691 EMBL· GenBank· DDBJ | AIU58686.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM245141 EMBL· GenBank· DDBJ | AIY56013.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM986518 EMBL· GenBank· DDBJ | AJV86964.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT819231 EMBL· GenBank· DDBJ | ALM03554.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY399199 EMBL· GenBank· DDBJ | AQU13808.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX977307 EMBL· GenBank· DDBJ | AQZ25258.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY782166 EMBL· GenBank· DDBJ | ASC43281.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF362770 EMBL· GenBank· DDBJ | ASF84708.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF362884 EMBL· GenBank· DDBJ | ASF86190.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF056543 EMBL· GenBank· DDBJ | ASS03990.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY797169 EMBL· GenBank· DDBJ | AUG82337.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF591562 EMBL· GenBank· DDBJ | AVL92192.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG182449 EMBL· GenBank· DDBJ | AXF36333.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK059572 EMBL· GenBank· DDBJ | QCB17648.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK491383 EMBL· GenBank· DDBJ | QEG55421.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK134289 EMBL· GenBank· DDBJ | QGW54056.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT079106 EMBL· GenBank· DDBJ | QIV22338.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN687119 EMBL· GenBank· DDBJ | QLH90379.1 EMBL· GenBank· DDBJ | Genomic DNA |