Q85AE9 · Q85AE9_ECHMA

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processoxidative phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    Q85AE9

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane30-55Helical
Transmembrane76-100Helical
Transmembrane120-143Helical
Transmembrane155-182Helical
Transmembrane215-233Helical
Transmembrane240-263Helical
Transmembrane275-298Helical
Transmembrane310-331Helical
Transmembrane343-360Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-361Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    361
  • Mass (Da)
    39,192
  • Last updated
    2003-06-01 v1
  • Checksum
    D1082528B56F0693
VGTAMSVIIRAELAQPGSLLNDDQIYNXVVTAHALVMIFFMVMPIMIGGFGNWLIPLMIGAPDMAFPRMNNMSFWLVPPSFILLLASAGVESGAGTGWTIYPPLSSNIAHAGGSVDLAIFSLHLAGASSILASINFITTIINMRTPGMSFDRLPLFVWSVFVTAFLLLLSLPVLAGAITMLLTDRNINTTFFDPAGGGDPILFQHLFXXXXHPEVYILILPGFGMISHVIAHYSGKREPFGYLGMVYAMIAIGVLGFLVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKVFSWMATLQGSNLQWETPLFWALGFVFLFTLGGLTGIVLANSSIDVVLHDTYYVVAHFHYVLSMGAVFAI

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue361

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY262912
EMBL· GenBank· DDBJ
AAP31634.1
EMBL· GenBank· DDBJ
Genomic DNA
AY262913
EMBL· GenBank· DDBJ
AAP31635.1
EMBL· GenBank· DDBJ
Genomic DNA
AY262915
EMBL· GenBank· DDBJ
AAP31637.1
EMBL· GenBank· DDBJ
Genomic DNA
AY262916
EMBL· GenBank· DDBJ
AAP31638.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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