Q85041 · GM_SUHV

Function

function

Envelope glycoprotein important for virion assembly and egress. Plays a role in the correct incorporation of gH-gL into virion membrane. Directs the glycoprotein N (gN) to the host trans-Golgi network.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell endosome membrane
Cellular Componenthost cell Golgi apparatus
Cellular Componenthost cell nuclear inner membrane
Cellular Componentmembrane
Cellular Componentviral envelope
Cellular Componentvirion membrane
Biological Processvirion assembly

Names & Taxonomy

Protein names

  • Recommended name
    Envelope glycoprotein M
  • Short names
    gM

Gene names

    • Name
      gM
    • ORF names
      UL10

Organism names

  • Taxonomic identifier
  • Strain
    • Kaplan
  • Taxonomic lineage
    Viruses > Duplodnaviria > Heunggongvirae > Peploviricota > Herviviricetes > Herpesvirales > Orthoherpesviridae > Alphaherpesvirinae > Varicellovirus > Varicellovirus suidalpha1

Accessions

  • Primary accession
    Q85041
  • Secondary accessions
    • Q5PP86
    • Q85042

Subcellular Location

Virion membrane
; Multi-pass membrane protein
Host endosome membrane
; Multi-pass membrane protein
Host nucleus inner membrane
; Multi-pass membrane protein
Note: During virion morphogenesis, this protein accumulates in the trans-Golgi network where secondary envelopment occurs.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-14Intravirion
Transmembrane15-35Helical
Topological domain36-83Virion surface
Transmembrane84-104Helical
Topological domain105-130Intravirion
Transmembrane131-151Helical
Topological domain152-154Virion surface
Transmembrane155-175Helical
Topological domain176-207Intravirion
Transmembrane208-228Helical
Topological domain229-241Virion surface
Transmembrane242-262Helical
Topological domain263-264Intravirion
Transmembrane265-285Helical
Topological domain286-303Virion surface
Transmembrane304-324Helical
Topological domain325-393Intravirion

Keywords

PTM/Processing

Features

Showing features for chain, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_50000959511-393Envelope glycoprotein M
Disulfide bond45Interchain (with gN)

Keywords

Interaction

Subunit

Interacts (via N-terminus) with gN (via N-terminus). The gM-gN heterodimer forms the gCII complex.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the herpesviridae glycoprotein M family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    393
  • Mass (Da)
    41,546
  • Last updated
    1996-11-01 v1
  • Checksum
    527613E8DE169D8A
MCGPRNAEAVSWRSWLIEVCGFALAALTLVLTLIFASLPEMGFPCFYATVADYDTLNDTSGGVWTRQPLVAPALFLETPTVTSFFGFTATVLLAHALYAVAGAVVLRREAGRLAFQPSVVLYAASTVAAPGTLMLGALCAWTLQAVVLLMAHKQAGLAAAAYITHFVFLALFGACHACKGTGDVRAALAASPPLRRVAVHARAVVTNVVLGAVGLGAAVVGLMLGVLLANSFHISLWKTAEAALAVFTLLALALMVFVEVVVSGYVQVLPTPAFCVLVASAAFGVSAHRYFAKFSEALGETHGVVIGTRAVLAVLSLIALAMIVVRLVRACIAHRARGSRFYANVDKARTTARRYLQKRLHGRGNDEYLLAPGSGDDEFDDGDEVVYENLGFE

Sequence caution

The sequence CAA65905.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X97257
EMBL· GenBank· DDBJ
CAA65904.1
EMBL· GenBank· DDBJ
Genomic DNA
X97257
EMBL· GenBank· DDBJ
CAA65905.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation
BK001744
EMBL· GenBank· DDBJ
DAA02185.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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