Q85041 · GM_SUHV
- ProteinEnvelope glycoprotein M
- GenegM
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids393 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Envelope glycoprotein important for virion assembly and egress. Plays a role in the correct incorporation of gH-gL into virion membrane. Directs the glycoprotein N (gN) to the host trans-Golgi network.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | host cell endosome membrane | |
Cellular Component | host cell Golgi apparatus | |
Cellular Component | host cell nuclear inner membrane | |
Cellular Component | membrane | |
Cellular Component | viral envelope | |
Cellular Component | virion membrane | |
Biological Process | virion assembly |
Names & Taxonomy
Protein names
- Recommended nameEnvelope glycoprotein M
- Short namesgM
Gene names
Organism names
- Strain
- Taxonomic lineageViruses > Duplodnaviria > Heunggongvirae > Peploviricota > Herviviricetes > Herpesvirales > Orthoherpesviridae > Alphaherpesvirinae > Varicellovirus > Varicellovirus suidalpha1
Accessions
- Primary accessionQ85041
- Secondary accessions
Subcellular Location
UniProt Annotation
GO Annotation
Virion membrane ; Multi-pass membrane protein
Host endosome membrane ; Multi-pass membrane protein
Host nucleus inner membrane ; Multi-pass membrane protein
Note: During virion morphogenesis, this protein accumulates in the trans-Golgi network where secondary envelopment occurs.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-14 | Intravirion | ||||
Sequence: MCGPRNAEAVSWRS | ||||||
Transmembrane | 15-35 | Helical | ||||
Sequence: WLIEVCGFALAALTLVLTLIF | ||||||
Topological domain | 36-83 | Virion surface | ||||
Sequence: ASLPEMGFPCFYATVADYDTLNDTSGGVWTRQPLVAPALFLETPTVTS | ||||||
Transmembrane | 84-104 | Helical | ||||
Sequence: FFGFTATVLLAHALYAVAGAV | ||||||
Topological domain | 105-130 | Intravirion | ||||
Sequence: VLRREAGRLAFQPSVVLYAASTVAAP | ||||||
Transmembrane | 131-151 | Helical | ||||
Sequence: GTLMLGALCAWTLQAVVLLMA | ||||||
Topological domain | 152-154 | Virion surface | ||||
Sequence: HKQ | ||||||
Transmembrane | 155-175 | Helical | ||||
Sequence: AGLAAAAYITHFVFLALFGAC | ||||||
Topological domain | 176-207 | Intravirion | ||||
Sequence: HACKGTGDVRAALAASPPLRRVAVHARAVVTN | ||||||
Transmembrane | 208-228 | Helical | ||||
Sequence: VVLGAVGLGAAVVGLMLGVLL | ||||||
Topological domain | 229-241 | Virion surface | ||||
Sequence: ANSFHISLWKTAE | ||||||
Transmembrane | 242-262 | Helical | ||||
Sequence: AALAVFTLLALALMVFVEVVV | ||||||
Topological domain | 263-264 | Intravirion | ||||
Sequence: SG | ||||||
Transmembrane | 265-285 | Helical | ||||
Sequence: YVQVLPTPAFCVLVASAAFGV | ||||||
Topological domain | 286-303 | Virion surface | ||||
Sequence: SAHRYFAKFSEALGETHG | ||||||
Transmembrane | 304-324 | Helical | ||||
Sequence: VVIGTRAVLAVLSLIALAMIV | ||||||
Topological domain | 325-393 | Intravirion | ||||
Sequence: VRLVRACIAHRARGSRFYANVDKARTTARRYLQKRLHGRGNDEYLLAPGSGDDEFDDGDEVVYENLGFE |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_5000095951 | 1-393 | Envelope glycoprotein M | |||
Sequence: MCGPRNAEAVSWRSWLIEVCGFALAALTLVLTLIFASLPEMGFPCFYATVADYDTLNDTSGGVWTRQPLVAPALFLETPTVTSFFGFTATVLLAHALYAVAGAVVLRREAGRLAFQPSVVLYAASTVAAPGTLMLGALCAWTLQAVVLLMAHKQAGLAAAAYITHFVFLALFGACHACKGTGDVRAALAASPPLRRVAVHARAVVTNVVLGAVGLGAAVVGLMLGVLLANSFHISLWKTAEAALAVFTLLALALMVFVEVVVSGYVQVLPTPAFCVLVASAAFGVSAHRYFAKFSEALGETHGVVIGTRAVLAVLSLIALAMIVVRLVRACIAHRARGSRFYANVDKARTTARRYLQKRLHGRGNDEYLLAPGSGDDEFDDGDEVVYENLGFE | ||||||
Disulfide bond | 45 | Interchain (with gN) | ||||
Sequence: C |
Keywords
- PTM
Interaction
Subunit
Interacts (via N-terminus) with gN (via N-terminus). The gM-gN heterodimer forms the gCII complex.
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length393
- Mass (Da)41,546
- Last updated1996-11-01 v1
- Checksum527613E8DE169D8A
Sequence caution
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X97257 EMBL· GenBank· DDBJ | CAA65904.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X97257 EMBL· GenBank· DDBJ | CAA65905.1 EMBL· GenBank· DDBJ | Genomic DNA | Different initiation | |
BK001744 EMBL· GenBank· DDBJ | DAA02185.1 EMBL· GenBank· DDBJ | Genomic DNA |