Q84WV6 · MORC1_ARATH

Function

function

Mediator of defense signaling triggered by distinct classes of R proteins. Required during hypersensitive response (HR) that confers disease resistance to turnip crinkle virus (TCV). Exhibits ATPase activity (PubMed:18191794, PubMed:19704828).
Contributes to resistance against Pseudomonas syringae and Hyaloperonospora arabidopsidis, at early stages prior to cytosolic calcium ions Ca2+ accumulation (PubMed:20332379).
Required for pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI), basal resistance, non-host resistance and systemic acquired resistance (SAR). Binds DNA/RNA in a non-specific manner and exhibits endonuclease activity. Probably involved in DNA repair (PubMed:23250427).
Required for both RPP8- and SSI4-mediated resistance responses, thus being involved in both TIR- and CC-NB-LRR pathways (PubMed:18191794).
Involved in RNA-directed DNA methylation (RdDM) as a component of the RdDM machinery and required for gene silencing (PubMed:24799676).
May also be involved in the regulation of chromatin architecture to maintain gene silencing (PubMed:22555433, PubMed:24799676).

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Uses preferentially Mn2+ and, to a lesser extent, Mg2+ as cofactors.

GO annotations

AspectTerm
Cellular Componentendosome
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionDNA binding
Molecular Functionendonuclease activity
Molecular FunctionRNA binding
Biological Processchromatin organization
Biological Processdefense response to virus
Biological ProcessDNA repair
Biological Processplant-type hypersensitive response
Biological Processpositive regulation of defense response to bacterium
Biological Processpositive regulation of defense response to virus by host
Biological Processpositive regulation of plant-type hypersensitive response
Biological Processpositive regulation of systemic acquired resistance
Biological Processregulation of DNA repair
Biological Processregulatory ncRNA-mediated gene silencing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein MICRORCHIDIA 1
  • EC number
  • Short names
    AtMORC1
  • Alternative names
    • Protein COMPROMISED RECOGNITION OF TCV 1

Gene names

    • Name
      MORC1
    • Synonyms
      CRT1
    • ORF names
      C7A10.1020
      , F23E13.180
    • Ordered locus names
      At4g36290

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q84WV6
  • Secondary accessions
    • O23245
    • O65520
    • Q56WA8
    • Q9C5D9

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Nucleus
Endosome
Note: Present in nuclear bodies near chromocenters (PubMed:22555433).
Localized in endosome-like vesicles displaying rapid cytosolic streaming (PubMed:20332379).
Accumulates in the nucleus following pathogen-associated molecular pattern (PAMP) treatment or infection with an avirulent pathogen (PubMed:23250427).

Keywords

Phenotypes & Variants

Disruption phenotype

Loss of ATPase activity. Increased sensitivity to turnip crinkle virus (TCV) leading to spreading hypersensitive response (HR) and impaired control of viral replication and spread. Suppression of HR-like cell death induced by Pseudomonas syringae avrRpt2. Suppression of lesion formation and partial suppression of stunted growth of ssi4 mutant (PubMed:18191794).
In the double mutant crt1-2 crh1-1, compromised resistance to avirulent Pseudomonas syringae and Hyaloperonospora arabidopsidis associated with compromised cytosolic calcium accumulation upon infection (PubMed:20332379).
Impaired gene silencing due to decondensation of chromocenters leading to the derepression of DNA-methylated genes and transposable elements (TEs); DNA and histone methylation seems normal (PubMed:22555433, PubMed:24799676).
The double mutant crt1-2 crh1-1 exhibits also an increased sensitivity to turnip crinkle virus (TCV), and reduced defense mediated by flg22 against Pseudomonas syringae (Pst). Impaired non-host resistance toward P. infestans and altered systemic acquired resistance (SAR) triggered by P. syringae pv. maculicola (Psm) AvrRpt2 cor-. Reduced sensitivity to the DNA-damaging agent mitomycin C (PubMed:23250427).

Variants

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The viewer provides 61 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004349761-635Protein MICRORCHIDIA 1

Proteomic databases

Expression

Tissue specificity

Expressed constitutively.

Gene expression databases

Interaction

Subunit

Homodimer and heterodimer with MORC6. Component of an RNA-directed DNA methylation (RdDM) complex that contains at least MORC6, MORC1/CRT1, MORC2, SWI3D and SUVH9. Binds directly to SUVH2 and SUVH9 (PubMed:24465213, PubMed:24799676).
Interacts with the resistance proteins RCY1, RPM1, SNC1, RPP8, SSI4 and RPS2 (PubMed:18191794, PubMed:20332379).
The interactions with various resistance proteins are disrupted when these resistance proteins are activated (PubMed:20332379).
Interacts with the PAMP recognition receptor FLS2 (PubMed:23250427).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, coiled coil.

TypeIDPosition(s)Description
Region491-511Disordered
Compositional bias495-510Polar residues
Coiled coil588-635

Sequence similarities

Belongs to the MORC ATPase protein family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    635
  • Mass (Da)
    70,807
  • Last updated
    2003-06-01 v1
  • Checksum
    0889A04DBCFBAB8D
MAKNYTVADVVNIDSDSDSDDDNGGVIGMVPSLASLIENQKVSIADAATVAPRETLECRSFWKAGENFVIPSSVTLTAIGMVEHARVHPKFLHSNATSHKWAFGAIAELLDNAVDEIQNGATVVKIDKINIVKDNTPALVFQDNGGGMDPNGIRKCMSLGYSSKKSNTTIGQYGNGFKTSTMRLGADAMVFSRSTRGGKSTQSIGLLSYTFLRKTGQDDVIVPMIDFDISSDSPQPIIYGSPGDWSTNLNILLKWSPFSTMVELLQQFEDIGTHGTKVIIYNLWLNDEGIYELSFDDDDVDIRLRDENAQDGKRLHAKTLEVRSHISYRYRHSLRAYISMLYLKKFKNFKIILRGVSVAQFNIADEFRHPETIMYKPQAAAVDYAATGIKVGFIKEAPKLPICGFNVYHKNRLIRPFWKVVLEGSTRGNGVMGVLEANFIEPAHDKQDFERSSLFLRLEARLKRITSDYWQNHCHIFGYQTAQIPADKSKRTVIPDQPPTVNTYNPSPLPSDRISHGGPIIREINLSNATSSRTAAVAAPHLRNYTGLRNNFQPVQLNPQPPAAGDTGNNLVGKLAAEIREENLQLFMRCEEYVKKENEVEQTVKSLEKELEEIKSKCAQLALLVDAKKKEMQQV

Sequence caution

The sequence BAD95165.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence CAA18135.1 differs from that shown. Reason: Erroneous gene model prediction
The sequence CAB16854.1 differs from that shown. Reason: Erroneous gene model prediction
The sequence CAB80300.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict77in Ref. 4; AAK26024
Compositional bias495-510Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Z99708
EMBL· GenBank· DDBJ
CAB16854.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
AL022141
EMBL· GenBank· DDBJ
CAA18135.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
AL161589
EMBL· GenBank· DDBJ
CAB80300.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002687
EMBL· GenBank· DDBJ
AEE86644.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360314
EMBL· GenBank· DDBJ
AAK26024.1
EMBL· GenBank· DDBJ
mRNA
BT001940
EMBL· GenBank· DDBJ
AAN71939.1
EMBL· GenBank· DDBJ
mRNA
AK222136
EMBL· GenBank· DDBJ
BAD95165.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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