Q84W65 · SUFE1_ARATH

Function

function

Participates in cysteine desulfurization mediated by NFS2 in chloroplast and NIFS1 in mitochondrion (PubMed:16437155).
Activates the cysteine desulfurase activity of NFS2 (PubMed:16455656).
Cysteine desulfurization mobilizes sulfur from L-cysteine to yield L-alanine and supplies the inorganic sulfur for iron-sulfur (Fe-S) cluster formation. Glutaredoxins regulate SUFE1 activity by inducing its reduction and deglutathionylation (PubMed:24203231).

Miscellaneous

Over-expression of SUFE1 leads to retarded growth and chlorosis.

Pathway

Cofactor biosynthesis; iron-sulfur cluster biosynthesis.

Features

Showing features for active site.

137150100150200250300350
TypeIDPosition(s)Description
Active site131Cysteine persulfide intermediate

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchloroplast
Cellular Componentchloroplast stroma
Cellular Componentcytosol
Cellular Componentmitochondrion
Molecular Functionenzyme activator activity
Biological Processembryo development ending in seed dormancy

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    SufE-like protein 1, chloroplastic/mitochondrial
  • Alternative names
    • Chloroplastic SufE
      (CpSufE
      )
    • Protein EMBRYO DEFECTIVE 1374
    • Protein SULFUR E
      (AtSUFE
      )
    • Protein SULFUR E 1
      (AtSUFE1
      )

Gene names

    • Name
      SUFE1
    • Synonyms
      EMB1374, SUFE
    • ORF names
      M3E9.70
    • Ordered locus names
      At4g26500

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q84W65
  • Secondary accessions
    • O65584

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Phenotypes & Variants

Disruption phenotype

Embryonic lethality when homozygous.

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis131Loss of function.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 26 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for transit peptide, chain, modified residue.

TypeIDPosition(s)Description
Transit peptide1-66Chloroplast and mitochondrion
ChainPRO_000025065367-371SufE-like protein 1, chloroplastic/mitochondrial
Modified residue131S-glutathionyl cysteine

Post-translational modification

Glutathionylated. Glutathionylation strongly reduces the stimulation of NFS2 activity.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in roots, leaves, stems and flowers.

Gene expression databases

Interaction

Subunit

Heterotetramer with NFS2 (PubMed:16455656).
Interacts with NFS2 and NIFS1 (PubMed:16437155).
Interacts in vitro with GRXS14, GRXS15, GRXS16 and GRXS17, but not with GRXC5 (PubMed:24203231).
Interacts in vivo only with GRXS14 and GRXS16 (PubMed:24203231).

Protein-protein interaction databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region218-249Disordered

Sequence similarities

Belongs to the SufE family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    371
  • Mass (Da)
    40,834
  • Last updated
    2006-10-03 v2
  • Checksum
    1843F0670DC057C3
MAAAMSSSCCASSLRLIPFKRTLFSSIHYPAKTLLLRPLKPSEVPSFRRTIITFQKISTGIVPPPSASSSPSSYGDLQPIEELPPKLQEIVKLFQSVQEPKAKYEQLMFYGKNLTPLDSQFKTRENKVEGCVSQVWVRAFFDEERNVVYEADSDSVLTKGLAALLVKGLSGRPVPEILRITPDFAVLLGLQQSLSPSRNNGLLNMLKLMQKKALHLEVKGEEDSSSGESSESSFVSIPETKDEANVPEVDLESKPDLVEDLGTEKIDDSESGSNVVALGSRGMRIREKLEKELDPVELEVEDVSYQHAGHAAVRGSAGDDGETHFNLRIVSDAFQGKSLVKRHRLIYDLLQDELKSGLHALSIVAKTPAEV

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict160in Ref. 3; AAO42209

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL022223
EMBL· GenBank· DDBJ
CAA18220.1
EMBL· GenBank· DDBJ
Genomic DNA
AL161565
EMBL· GenBank· DDBJ
CAB79505.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002687
EMBL· GenBank· DDBJ
AEE85210.1
EMBL· GenBank· DDBJ
Genomic DNA
BT004190
EMBL· GenBank· DDBJ
AAO42209.1
EMBL· GenBank· DDBJ
mRNA
BT021125
EMBL· GenBank· DDBJ
AAX22260.1
EMBL· GenBank· DDBJ
mRNA
AY084591
EMBL· GenBank· DDBJ
AAM61156.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp