Q84TA3 · LKHA4_ORYSJ

Function

function

Aminopeptidase that preferentially cleaves di- and tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze the epoxide leukotriene LTA4 but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B4 as the product compared to the homologous mammalian enzyme (in vitro).

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

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Type
IDPosition(s)Description
Binding site129-131substrate
Binding site278-282substrate
Binding site305Zn2+ (UniProtKB | ChEBI); catalytic
Active site306Proton acceptor
Binding site309Zn2+ (UniProtKB | ChEBI); catalytic
Binding site328Zn2+ (UniProtKB | ChEBI); catalytic
Active site393Proton donor
Binding site562-564substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionepoxide hydrolase activity
Molecular Functionmetallopeptidase activity
Molecular Functionzinc ion binding
Biological Processleukotriene biosynthetic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Leucine aminopeptidase
  • EC number
  • Alternative names
    • Epoxide hydrolase (EC:3.3.2.10) . EC:3.3.2.10 (UniProtKB | ENZYME | Rhea)
    • Leukotriene A-4 hydrolase homolog (LTA-4 hydrolase)

Gene names

    • Name
      LKHA4
    • ORF names
      OJ1754_E06.9, OsJ_13129
    • Ordered locus names
      Os03g0819100, LOC_Os03g60460

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Nipponbare
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Oryzoideae > Oryzeae > Oryzinae > Oryza > Oryza sativa

Accessions

  • Primary accession
    Q84TA3
  • Secondary accessions
    • A0A0N7KIA5

Proteomes

Genome annotation databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue (large scale data).

Type
IDPosition(s)Source
Description
ChainPRO_00004245891-611UniProtLeucine aminopeptidase
Modified residue (large scale data)476PTMeXchangePhosphoserine
Modified residue (large scale data)570PTMeXchangePhosphotyrosine
Modified residue (large scale data)571PTMeXchangePhosphoserine
Modified residue (large scale data)589PTMeXchangePhosphoserine

Proteomic databases

PTM databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the peptidase M1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    611
  • Mass (Da)
    67,792
  • Last updated
    2003-06-01 v1
  • Checksum
    9A99FA6F56C4D8FE
MPPVDPHSYTDGDHPVTAKAALAFYLDFAASTIHASALLTLSAPHSGDLLLDTRALAVHSASTASGPPSPIPFSLADAADPVLGSALTLTLPPDTTSFLLTFSTSPSASALQWLSPPQTASSLPFVFSQCQSIHARSVFPCHDTPAARITFDLLLNVPTQLSAVAAARHVSRRDPLPSDHRGACDDALWCAPGRIVEEFQMEQSVPPYLFAFAAGGIGFRDLGPRTRVYAEGGDKVLDEAAREFAGVEEMVKVGESLFGPYEWERFDLLVLPPSFPYGGMENPRMVFLTPTVIKGDAAGAQVVAHELAHSWTGNLITNKTNEDFWLNEGFTTYAERRIVEVVQGEERAALNMGIGWRGLNRMMERFKDNMEYTKLKPKMAGIDPDDVYSEVPYEKGFQFLWRIERQIGRPAFDEFLKNYISTFKFKSIDTETFLEFLKTNVPGIENQIDLQLWIEGTGIPPDAMEPESAIYKKICSLAAEFKSGKLPSEDEVADWSGQEWELYLENLPTDVEASQVTALDERYKLSESCDYEVKVAFLQLAIPTGCRCYFNEVEKCLKQVGRMKYLRPLYSSLARCSGEEKMLAHRIFSEAHEFYHPIARSVAESILSKHG

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict30in Ref. 6; AK073744

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC104433
EMBL· GenBank· DDBJ
AAO65874.1
EMBL· GenBank· DDBJ
Genomic DNA
DP000009
EMBL· GenBank· DDBJ
ABF99571.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008209
EMBL· GenBank· DDBJ
BAF13624.1
EMBL· GenBank· DDBJ
Genomic DNA
AP014959
EMBL· GenBank· DDBJ
BAS87073.1
EMBL· GenBank· DDBJ
Genomic DNA
CM000140
EMBL· GenBank· DDBJ
EAZ29074.1
EMBL· GenBank· DDBJ
Genomic DNA
AK073744
EMBL· GenBank· DDBJ
-mRNA No translation available.

Genome annotation databases

Similar Proteins

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