Q84TA3 · LKHA4_ORYSJ
- ProteinLeucine aminopeptidase
- GeneLKHA4
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids611 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Aminopeptidase that preferentially cleaves di- and tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze the epoxide leukotriene LTA4 but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B4 as the product compared to the homologous mammalian enzyme (in vitro).
Catalytic activity
- an epoxide + H2O = an ethanediol
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 129-131 | substrate | |||
Binding site | 278-282 | substrate | |||
Binding site | 305 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Active site | 306 | Proton acceptor | |||
Binding site | 309 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 328 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Active site | 393 | Proton donor | |||
Binding site | 562-564 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | epoxide hydrolase activity | |
Molecular Function | metallopeptidase activity | |
Molecular Function | zinc ion binding | |
Biological Process | leukotriene biosynthetic process | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameLeucine aminopeptidase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Oryzoideae > Oryzeae > Oryzinae > Oryza > Oryza sativa
Accessions
- Primary accessionQ84TA3
- Secondary accessions
Proteomes
Genome annotation databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | ||
---|---|---|---|---|---|---|
Chain | PRO_0000424589 | 1-611 | UniProt | Leucine aminopeptidase | ||
Modified residue (large scale data) | 476 | PTMeXchange | Phosphoserine | |||
Modified residue (large scale data) | 570 | PTMeXchange | Phosphotyrosine | |||
Modified residue (large scale data) | 571 | PTMeXchange | Phosphoserine | |||
Modified residue (large scale data) | 589 | PTMeXchange | Phosphoserine | |||
Proteomic databases
PTM databases
Structure
Sequence
- Sequence statusComplete
- Length611
- Mass (Da)67,792
- Last updated2003-06-01 v1
- Checksum9A99FA6F56C4D8FE
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 30 | in Ref. 6; AK073744 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC104433 EMBL· GenBank· DDBJ | AAO65874.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DP000009 EMBL· GenBank· DDBJ | ABF99571.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008209 EMBL· GenBank· DDBJ | BAF13624.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP014959 EMBL· GenBank· DDBJ | BAS87073.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CM000140 EMBL· GenBank· DDBJ | EAZ29074.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK073744 EMBL· GenBank· DDBJ | - | mRNA | No translation available. |