Q83ZU9 · Q83ZU9_ECOLX
- ProteinBeta-lactamase
- GeneblaOXA-30
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids276 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- a beta-lactam + H2O = a substituted beta-amino acid
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 71 | Acyl-ester intermediate | ||||
Sequence: S |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | beta-lactamase activity | |
Molecular Function | penicillin binding | |
Biological Process | antibiotic catabolic process | |
Biological Process | response to antibiotic |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBeta-lactamase
- EC number
Gene names
Encoded on
- Plasmid RCS59_p
- Plasmid pC15-1a
- Plasmid pEC32009-KPC2
- Plasmid pEC32446-KPC2
- Plasmid pEC_Surv265-KPC2
- Plasmid pEc2A
- Plasmid pEc9
- Plasmid pGUE-NDM
- Plasmid pHKU1
- Plasmid pHSH2
- Plasmid pJIE101
- Plasmid pRCS52
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia
Accessions
- Primary accessionQ83ZU9
Proteomes
PTM/Processing
Features
Showing features for signal, chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-25 | |||||
Sequence: MKNTIHINFAIFLIIANIIYSSASA | ||||||
Chain | PRO_5015098957 | 26-276 | Beta-lactamase | |||
Sequence: STDISTVASPLFEGTEGCFLLYDASTNAEIAQFNKAKCATQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKTPKGMEIWNSNHTPKTWMQFSVVWVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLTEAWLESSLKISPEEQIQFLRKIINHNLPVKNSAIENTIENMYLQDLDNSTKLYGKTGAGFTANRTLQNGWFEGFIISKSGHKYVFVSALTGNLGSNLTSSIKAKKNAITILNTLNL | ||||||
Modified residue | 74 | N6-carboxylysine | ||||
Sequence: K |
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 42-262 | Penicillin-binding protein transpeptidase | ||||
Sequence: GCFLLYDASTNAEIAQFNKAKCATQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKTPKGMEIWNSNHTPKTWMQFSVVWVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLTEAWLESSLKISPEEQIQFLRKIINHNLPVKNSAIENTIENMYLQDLDNSTKLYGKTGAGFTANRTLQNGWFEGFIISKSGHKYVFVSALTGNLGSNLTSSIK |
Sequence similarities
Belongs to the class-D beta-lactamase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length276
- Mass (Da)30,880
- Last updated2003-06-01 v1
- Checksum5ADF7626422BA124
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY259086 EMBL· GenBank· DDBJ | AAP20920.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY224185 EMBL· GenBank· DDBJ | AAP51284.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY458016 EMBL· GenBank· DDBJ | AAR25029.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF415651 EMBL· GenBank· DDBJ | ABN69071.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF543148 EMBL· GenBank· DDBJ | ABQ02276.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU089669 EMBL· GenBank· DDBJ | ABX75130.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ841897 EMBL· GenBank· DDBJ | ACO55744.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ896555 EMBL· GenBank· DDBJ | ACX50629.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ896556 EMBL· GenBank· DDBJ | ACX50630.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ896557 EMBL· GenBank· DDBJ | ACX50631.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ896558 EMBL· GenBank· DDBJ | ACX50632.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ896559 EMBL· GenBank· DDBJ | ACX50633.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ896560 EMBL· GenBank· DDBJ | ACX50634.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU418922 EMBL· GenBank· DDBJ | AER36608.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ364967 EMBL· GenBank· DDBJ | AFI72861.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC960485 EMBL· GenBank· DDBJ | AGW00947.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ192415 EMBL· GenBank· DDBJ | AIM47151.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF914287 EMBL· GenBank· DDBJ | AIV43455.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR338947 EMBL· GenBank· DDBJ | AKO22380.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR822247 EMBL· GenBank· DDBJ | ALF35432.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP018991 EMBL· GenBank· DDBJ | AQV76620.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY887590 EMBL· GenBank· DDBJ | ASF79900.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LO017736 EMBL· GenBank· DDBJ | CRH08424.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
ABONVU020000059 EMBL· GenBank· DDBJ | EMJ5257045.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
ABONVU020000094 EMBL· GenBank· DDBJ | EMJ5257135.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
ABKSHZ030000052 EMBL· GenBank· DDBJ | EMM9725021.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
ABKSHZ030000072 EMBL· GenBank· DDBJ | EMM9725136.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABCAF010000096 EMBL· GenBank· DDBJ | HAH6605173.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABCAF010000149 EMBL· GenBank· DDBJ | HAH6605336.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABGKZ010000066 EMBL· GenBank· DDBJ | HAJ5153039.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABGKZ010000191 EMBL· GenBank· DDBJ | HAJ5153540.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DADPIR010000112 EMBL· GenBank· DDBJ | HAZ7494985.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DADPIR010000252 EMBL· GenBank· DDBJ | HAZ7495269.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RYCF01000290 EMBL· GenBank· DDBJ | MQK27738.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WCEW01000112 EMBL· GenBank· DDBJ | MTE92582.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WSXK01000226 EMBL· GenBank· DDBJ | MWF98601.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAAJRI010000086 EMBL· GenBank· DDBJ | NGE91754.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LT985271 EMBL· GenBank· DDBJ | SPE00919.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP104950 EMBL· GenBank· DDBJ | UYA94280.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP104951 EMBL· GenBank· DDBJ | UYA94385.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP104953 EMBL· GenBank· DDBJ | UYA94618.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP107128 EMBL· GenBank· DDBJ | WLM98401.1 EMBL· GenBank· DDBJ | Genomic DNA |