Q83045 · R1AB_LIYV9
- ProteinReplicase polyprotein 1ab
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids2379 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Catalytic activity
- a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)
Features
Showing features for active site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 344 | For leader protease activity | ||||
Sequence: C | ||||||
Active site | 393 | For leader protease activity | ||||
Sequence: H | ||||||
Site | 413-414 | Cleavage; by the leader protease | ||||
Sequence: AS |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | cysteine-type peptidase activity | |
Molecular Function | mRNA methyltransferase activity | |
Molecular Function | RNA binding | |
Molecular Function | RNA helicase activity | |
Molecular Function | RNA-dependent RNA polymerase activity | |
Biological Process | DNA-templated transcription | |
Biological Process | methylation | |
Biological Process | mRNA modification | |
Biological Process | proteolysis | |
Biological Process | RNA processing | |
Biological Process | viral RNA genome replication | |
Biological Process | viral translational frameshifting |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameReplicase polyprotein 1ab
- Cleaved into 2 chains
Organism names
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Kitrinoviricota > Alsuviricetes > Martellivirales > Closteroviridae > Crinivirus > Lettuce infectious yellows virus
- Virus hosts
Accessions
- Primary accessionQ83045
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000402511 | 1-413 | Leader protease | |||
Sequence: MALEVESAFSLSYLLKENKQTSNNLFSLIQVPYTKMTHAKGKKTHLLRCILGSPFETLTKSSIRRSLKNLREVCNLPYCNFKKIPKNISYKYQNPFLKLYEINNNFINCKVGATGNTNSTYDWRNLSTIGNGWSVTSYHNDSVSRLHVSMVNNIPNSNTKKLSWWVTRVRSKNPWKRPYKVIYQRDFRDDGIKPYVSEFILYAPKNRADLEMQSILLSSVECFQDIKYALNYWTNLKFKEICNSALKRFTQTNIIITPVKPRVVSVNKAREVSSSVEVKLQRYEREGEVFVVSKAGKEDTRVLNDDNAIRNLFNATLNGGKYKLHPEAKSATGKRFKYYKDGFCWLDVFADANRRIPEWVKPHCLLTGSVLMSCGLWDFAKRKMVSVSHGLLHYDRKLERSSARAGVRDFVGA | ||||||
Chain | PRO_0000402510 | 1-2379 | Replicase polyprotein 1ab | |||
Sequence: MALEVESAFSLSYLLKENKQTSNNLFSLIQVPYTKMTHAKGKKTHLLRCILGSPFETLTKSSIRRSLKNLREVCNLPYCNFKKIPKNISYKYQNPFLKLYEINNNFINCKVGATGNTNSTYDWRNLSTIGNGWSVTSYHNDSVSRLHVSMVNNIPNSNTKKLSWWVTRVRSKNPWKRPYKVIYQRDFRDDGIKPYVSEFILYAPKNRADLEMQSILLSSVECFQDIKYALNYWTNLKFKEICNSALKRFTQTNIIITPVKPRVVSVNKAREVSSSVEVKLQRYEREGEVFVVSKAGKEDTRVLNDDNAIRNLFNATLNGGKYKLHPEAKSATGKRFKYYKDGFCWLDVFADANRRIPEWVKPHCLLTGSVLMSCGLWDFAKRKMVSVSHGLLHYDRKLERSSARAGVRDFVGASNEAVQREDFRDLDLRVEEFAERVLETANLRSDNRLIDNILTRASDYINKKSKESKELDINVCLSMDEKKMITNLFPDIQMSFNQKSYSNHGVFNAMRACENFYFSRKFKNSDYIDAGGDVVSTLRSKNHNVHICSPRLDLKDAARHIQRATVIDGLKGYGETISFCTNKTEDCAVNRDIIIAVEVYDMTLRDMAKAMLSHGSRKFEFSCIIPPEIFTKECNVELYEGRLKVTRIGDNVEYYYGSNGETFSHSCQTLKDILSVQVFQFGGRVFKKTLEHSRGQLHFFSICICEKIEPGSVKLKTYYQRSELDKVTLRIPVKDSFGVVTHYIIKEDREFVSSMIEYVANTGIKIDDKMVEWTYSQYRAKKTVTIKSGKVTQKETRIRKELIPGFIAIIMSEGIRAREKTHYLAKMLYTSHYKPSIVNIIFRLIMHFLGGTKRFIYESLVDCLKFLTNSDYIDTIVNTESRIEDLDKWFVFEQNVTITTDAEDQPSILEQSVKTFLSKYSEDVYERGDRSEFELEEFSSEQDLVDQLLNSGGGSKEDEWFYSYIFSIVRTKCTLSLAWRWTNRIFNFITSCRAKGKDFVKYIYEIIKIIINKPWEALCHYLVQGYKTVLKIPMTCVDSVNYLKRKSLEKILSYFSHERADDEYIFPGYDSDFSEESGDYGDENTELDSRSRCTVIKSKVEMLFRNIKGHIEKFLQRCGIIDQYNKIYHWFKSILTDVDCFNSVLNFITHTGCDALLAVLTGHFSIASCALKFMTDVVIEKNLSEKHHTTTKLIAGNLTQCIYKLDFIHPIWIPIRWGVKEISKIHIKKKLLNWRSTKEVTNESICKDLVHKSYIKYFDIKKAVWLLWFSLLIIFLHPTLGFFILFSIYPAIEIKRYYNNVVCFNNIKMSYPHVIDRLGGTYNFAKLKKAVREKFSENKSQGVKISEIPAEKDEDVMPPLEEVETPKRSVGRPSSKQDDIEDECNIKEDPTESLNFSNIEATSNRYDTLRVGNSKLCKFLRFYPKSKCYANIQTGDLIRDSIEEFYHLERSKLDIEISKMQRVVEIMNDTGRMLDNVRRMIDDRSMYVTLDGVSWYRLGCKDKNPAKEDFKAIFDHNFNIMEGNAKVKEFAVSSDEWRGMYSNERCRAIEQLFNDNNEMVRRPDVNGLKFYNKPPGAGKTTTIAKLMSKDLKNKVKCLALSYTKVGRLELIDKLKKDGIEKPEKYVKTYDSFLMNNDNILEIVNLYCDEVFMMHAGHFLTLLTKIAYQNGYCYGDVNQIPFINRDPYTPAYLSREFFRKQDLNYDTYTYRCPLDTCYLLSNLKDEMGNIIYAGGVKNVNEVYPTIRSLNLFGINVVGEVPVEYNAKYLTFTQDEKLNLQRHIDSQGGCRNAVSTVNEAQGCTFSEVNLVRLVQFDNPVMSDINQFVVAISRHTTTFKYFTPHSRLNDRVSNAISSLQSVSDFVLKTIILDSAFDVYTLNLTHRDFKLPLCRPPAARYESIIDLMDIISPGVAFYNYLHRTLIFEYSDYYLPPCEDLRITLSKSKPYHPGAYVVSKILGKGERNRPNTWKQVIQSLSHRNFNAPIINHKLDVKRSAQILYDSVVKSLRQDRLTEWYEPILPDLFKIGKWLDDRDGSKYRMLNRRLDFASLADKFKTLNLMVKGETKPKMDLSTYDSYNAPANIVYYQQIVNLYFSPIFLECFARLTYCLSDKIVLYSGMNTDVLAELIESKLPLGLNAYHTLEIDFSKFDKSQGTCFKLYEEMMYKMFGFSPELYDRDFKYTEYFCRAKATCGVDLELGTQRRTGSPNTWLSNTLVTLGMMLSSYDIDDIDLLLVSGDDSLIFSRKHLPNKTQEINKNFGMEAKYIEKSSPYFCSKFIVELNGKLKVIPDPIRFFEKLSIPIRQEDFVNGSVVKERFISFKDLMKEYDNDVAVIRIDEAVCYRYSIPVGCSYAALCYIHCCMSNFVSFRRIYDNCEIVWI | ||||||
Chain | PRO_0000402512 | 414-2379 | Methyltransferase/helicase/RNA-directed RNA polymerase | |||
Sequence: SNEAVQREDFRDLDLRVEEFAERVLETANLRSDNRLIDNILTRASDYINKKSKESKELDINVCLSMDEKKMITNLFPDIQMSFNQKSYSNHGVFNAMRACENFYFSRKFKNSDYIDAGGDVVSTLRSKNHNVHICSPRLDLKDAARHIQRATVIDGLKGYGETISFCTNKTEDCAVNRDIIIAVEVYDMTLRDMAKAMLSHGSRKFEFSCIIPPEIFTKECNVELYEGRLKVTRIGDNVEYYYGSNGETFSHSCQTLKDILSVQVFQFGGRVFKKTLEHSRGQLHFFSICICEKIEPGSVKLKTYYQRSELDKVTLRIPVKDSFGVVTHYIIKEDREFVSSMIEYVANTGIKIDDKMVEWTYSQYRAKKTVTIKSGKVTQKETRIRKELIPGFIAIIMSEGIRAREKTHYLAKMLYTSHYKPSIVNIIFRLIMHFLGGTKRFIYESLVDCLKFLTNSDYIDTIVNTESRIEDLDKWFVFEQNVTITTDAEDQPSILEQSVKTFLSKYSEDVYERGDRSEFELEEFSSEQDLVDQLLNSGGGSKEDEWFYSYIFSIVRTKCTLSLAWRWTNRIFNFITSCRAKGKDFVKYIYEIIKIIINKPWEALCHYLVQGYKTVLKIPMTCVDSVNYLKRKSLEKILSYFSHERADDEYIFPGYDSDFSEESGDYGDENTELDSRSRCTVIKSKVEMLFRNIKGHIEKFLQRCGIIDQYNKIYHWFKSILTDVDCFNSVLNFITHTGCDALLAVLTGHFSIASCALKFMTDVVIEKNLSEKHHTTTKLIAGNLTQCIYKLDFIHPIWIPIRWGVKEISKIHIKKKLLNWRSTKEVTNESICKDLVHKSYIKYFDIKKAVWLLWFSLLIIFLHPTLGFFILFSIYPAIEIKRYYNNVVCFNNIKMSYPHVIDRLGGTYNFAKLKKAVREKFSENKSQGVKISEIPAEKDEDVMPPLEEVETPKRSVGRPSSKQDDIEDECNIKEDPTESLNFSNIEATSNRYDTLRVGNSKLCKFLRFYPKSKCYANIQTGDLIRDSIEEFYHLERSKLDIEISKMQRVVEIMNDTGRMLDNVRRMIDDRSMYVTLDGVSWYRLGCKDKNPAKEDFKAIFDHNFNIMEGNAKVKEFAVSSDEWRGMYSNERCRAIEQLFNDNNEMVRRPDVNGLKFYNKPPGAGKTTTIAKLMSKDLKNKVKCLALSYTKVGRLELIDKLKKDGIEKPEKYVKTYDSFLMNNDNILEIVNLYCDEVFMMHAGHFLTLLTKIAYQNGYCYGDVNQIPFINRDPYTPAYLSREFFRKQDLNYDTYTYRCPLDTCYLLSNLKDEMGNIIYAGGVKNVNEVYPTIRSLNLFGINVVGEVPVEYNAKYLTFTQDEKLNLQRHIDSQGGCRNAVSTVNEAQGCTFSEVNLVRLVQFDNPVMSDINQFVVAISRHTTTFKYFTPHSRLNDRVSNAISSLQSVSDFVLKTIILDSAFDVYTLNLTHRDFKLPLCRPPAARYESIIDLMDIISPGVAFYNYLHRTLIFEYSDYYLPPCEDLRITLSKSKPYHPGAYVVSKILGKGERNRPNTWKQVIQSLSHRNFNAPIINHKLDVKRSAQILYDSVVKSLRQDRLTEWYEPILPDLFKIGKWLDDRDGSKYRMLNRRLDFASLADKFKTLNLMVKGETKPKMDLSTYDSYNAPANIVYYQQIVNLYFSPIFLECFARLTYCLSDKIVLYSGMNTDVLAELIESKLPLGLNAYHTLEIDFSKFDKSQGTCFKLYEEMMYKMFGFSPELYDRDFKYTEYFCRAKATCGVDLELGTQRRTGSPNTWLSNTLVTLGMMLSSYDIDDIDLLLVSGDDSLIFSRKHLPNKTQEINKNFGMEAKYIEKSSPYFCSKFIVELNGKLKVIPDPIRFFEKLSIPIRQEDFVNGSVVKERFISFKDLMKEYDNDVAVIRIDEAVCYRYSIPVGCSYAALCYIHCCMSNFVSFRRIYDNCEIVWI |
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 495-674 | Alphavirus-like MT | ||||
Sequence: SFNQKSYSNHGVFNAMRACENFYFSRKFKNSDYIDAGGDVVSTLRSKNHNVHICSPRLDLKDAARHIQRATVIDGLKGYGETISFCTNKTEDCAVNRDIIIAVEVYDMTLRDMAKAMLSHGSRKFEFSCIIPPEIFTKECNVELYEGRLKVTRIGDNVEYYYGSNGETFSHSCQTLKDIL | ||||||
Region | 1356-1381 | Disordered | ||||
Sequence: VMPPLEEVETPKRSVGRPSSKQDDIE | ||||||
Domain | 1538-1705 | +RNA virus helicase ATP-binding | ||||
Sequence: RGMYSNERCRAIEQLFNDNNEMVRRPDVNGLKFYNKPPGAGKTTTIAKLMSKDLKNKVKCLALSYTKVGRLELIDKLKKDGIEKPEKYVKTYDSFLMNNDNILEIVNLYCDEVFMMHAGHFLTLLTKIAYQNGYCYGDVNQIPFINRDPYTPAYLSREFFRKQDLNYD | ||||||
Domain | 1706-1874 | +RNA virus helicase C-terminal | ||||
Sequence: TYTYRCPLDTCYLLSNLKDEMGNIIYAGGVKNVNEVYPTIRSLNLFGINVVGEVPVEYNAKYLTFTQDEKLNLQRHIDSQGGCRNAVSTVNEAQGCTFSEVNLVRLVQFDNPVMSDINQFVVAISRHTTTFKYFTPHSRLNDRVSNAISSLQSVSDFVLKTIILDSAFD | ||||||
Domain | 2138-2251 | RdRp catalytic | ||||
Sequence: YHTLEIDFSKFDKSQGTCFKLYEEMMYKMFGFSPELYDRDFKYTEYFCRAKATCGVDLELGTQRRTGSPNTWLSNTLVTLGMMLSSYDIDDIDLLLVSGDDSLIFSRKHLPNKT |
Domain
Sequence similarities
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Ribosomal frameshifting. The replicase 1a is produced from conventional translation of the 1a ORF. The replicase 1ab is generated probably by a +1 ribosomal frameshifting mechanism occurring at the 1a-1b genes boundary.
Q83045-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameReplicase 1ab
- Length2,379
- Mass (Da)276,048
- Last updated2010-11-30 v2
- Checksum4EFB720D826A26F6
Q83044-1
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- NameReplicase 1a
Sequence caution
Keywords
- Coding sequence diversity
- Technical term