Q82DB1 · SECA1_STRAW

Function

function

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

Catalytic activity

  • ATP + H2O + cellular proteinSide 1 = ADP + phosphate + cellular proteinSide 2.
    EC:7.4.2.8 (UniProtKB | ENZYME | Rhea)

Features

Showing features for binding site.

1939100200300400500600700800900
TypeIDPosition(s)Description
Binding site85ATP (UniProtKB | ChEBI)
Binding site103-107ATP (UniProtKB | ChEBI)
Binding site504ATP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell envelope Sec protein transport complex
Cellular Componentcytosol
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functionprotein-exporting ATPase activity
Biological Processintracellular protein transmembrane transport
Biological Processprotein import
Biological Processprotein targeting
Biological Processprotein transport by the Sec complex

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein translocase subunit SecA 1
  • EC number

Gene names

    • Name
      secA1
    • Ordered locus names
      SAV_5071

Organism names

Accessions

  • Primary accession
    Q82DB1

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cytoplasm
Note: Distribution is 50-50.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003184641-939Protein translocase subunit SecA 1

Interaction

Subunit

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region848-939Disordered

Sequence similarities

Belongs to the SecA family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    939
  • Mass (Da)
    105,778
  • Last updated
    2003-06-01 v1
  • Checksum
    41806E7C012CCC4C
MSVLSKIMRAGEGKILRKLHRIADQVNSIEEDFVDLSDAELRALTDEYKQRYADGESLDDLLPEAFATVREAAKRVLGQRHYDVQMMGGAALHLGYVAEMKTGEGKTLVGTLPAYLNALSGDGVHLITVNDYLAERDSEMMGRVHKFLGLSVGCILANMTPAQRREQYGCDITYGTNNEFGFDYLRDNMAWSQDELVQRGHNFAVVDEVDSILVDEARTPLIISGPADQATKWYGDFAKLVTRLKKGEAGNTLKGIEETGDYEVDEKKRTVAIHESGVAKVEDWLGIDNLYESVNTPLVGYLNNAIKAKELFKKDKDYVVIDGEVMIVDEHTGRILAGRRYNEGMHQAIEAKEGVDIKDENQTLATITLQNFFRLYNKLSGMTGTAMTEAAEFHQIYKLGVVPIPTNKPMVRKDQSDLIYRTEVAKFDAVVDDIAEKHEKGQPILVGTTSVEKSEYLSQQLSKRGIQHEVLNAKQHDREATIVAQAGRKGAVTVATNMAGRGTDIKLGGNPDDLAEAELRQRGLDPEEHIEEWAAALPAALERAEKAVKAEFEEVKELGGLYVLGTERHESRRIDNQLRGRSGRQGDPGESRFYLSLGDDLMRLFKAQMVERVMSMANVPDDVPIENKMVTRAIASAQSQVETQNFETRKNVLKYDEVLNRQREVIYGERRRVLEGEDLQEQIHHFMDDTIDAYIEAETAEGFAEEWDLDRLWGAFKQLYPVKVTVDELEEAAGDRAGLTAEFISESIKDDIHEQYEQRETQLGSEIMRELERRVVLSVLDRKWREHLYEMDYLQEGIGLRAMAQKDPLVEYQREGFDMFTAMMDGIKEESVGYLFNLEVQVEQQVEEVPVEDEKPSLEKEDAVPAQAGARPEIRAKGLEAPQRPDRLHFSAPTVDGEGGIIEGDFSSDDDEEPVRSEADGLTRAERRKQSKGGRRRKK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BA000030
EMBL· GenBank· DDBJ
BAC72783.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp