Q828S5 · HGD_STRAW

Function

function

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.

Catalytic activity

Cofactor

Fe cation (UniProtKB | Rhea| CHEBI:24875 )

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site294Proton acceptor
Binding site337Fe cation (UniProtKB | ChEBI)
Binding site343Fe cation (UniProtKB | ChEBI)
Binding site352homogentisate (UniProtKB | ChEBI)
Binding site373Fe cation (UniProtKB | ChEBI)
Binding site373homogentisate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionhomogentisate 1,2-dioxygenase activity
Molecular Functioniron ion binding
Biological ProcessL-phenylalanine catabolic process
Biological Processtyrosine catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Homogentisate 1,2-dioxygenase
  • EC number
  • Short names
    HGDO
  • Alternative names
    • Homogentisate oxygenase
    • Homogentisic acid oxidase
    • Homogentisicase

Gene names

    • Name
      hmgA
    • Ordered locus names
      SAV_6587

Organism names

Accessions

  • Primary accession
    Q828S5

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002202551-438Homogentisate 1,2-dioxygenase

Interaction

Subunit

Hexamer; dimer of trimers.

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region16-40Disordered

Sequence similarities

Belongs to the homogentisate dioxygenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    438
  • Mass (Da)
    47,823
  • Last updated
    2003-06-01 v1
  • Checksum
    8E751EBA9B6F53BC
MSGDARKTAEGLAHLTGFGNEHASEAVPGALPEGRNSPQRAPLGLYAEQLSGSAFTEPRAHNRRSWLYRIRPSAAHPPFTRADNGAIRTAPFTETAPDPNRLRWNPLPEPPAGTDFVGGLWTLGGNGDATQRTGMAVHLYHANSSMDRVFSDADGELLIVPERGGLLLRTEFGLLHAEPGQVALVPRGVRFRVDLLDESARGYVCENYGAPFQLPDLGPIGANGLAAARDFKAPVAAYEDVEGPVEVVNKFCGNLWTATYDHSPLDVVAWHGNHVPYTYDLRRFNVLGTISYDHPDPSIFTVLTSPSDTPGLAGVDFVVFAPRWLVGEDTFRPPYFHRNVMSEYMGLIEGAYDAKAAGFVPGGGSLHNMMSAHGPDRETFDRASAAELRPQKIDDGLAFMFETRWPVTATAQAARAEHLQPAYDDVWQGLQRHFRPSD

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BA000030
EMBL· GenBank· DDBJ
BAC74298.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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