Q828S5 · HGD_STRAW
- ProteinHomogentisate 1,2-dioxygenase
- GenehmgA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids438 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.
Catalytic activity
- homogentisate + O2 = 4-maleylacetoacetate + H+
Cofactor
Pathway
Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 294 | Proton acceptor | ||||
Sequence: H | ||||||
Binding site | 337 | Fe cation (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 343 | Fe cation (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 352 | homogentisate (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 373 | Fe cation (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 373 | homogentisate (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | homogentisate 1,2-dioxygenase activity | |
Molecular Function | iron ion binding | |
Biological Process | L-phenylalanine catabolic process | |
Biological Process | tyrosine catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHomogentisate 1,2-dioxygenase
- EC number
- Short namesHGDO
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces
Accessions
- Primary accessionQ828S5
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000220255 | 1-438 | Homogentisate 1,2-dioxygenase | |||
Sequence: MSGDARKTAEGLAHLTGFGNEHASEAVPGALPEGRNSPQRAPLGLYAEQLSGSAFTEPRAHNRRSWLYRIRPSAAHPPFTRADNGAIRTAPFTETAPDPNRLRWNPLPEPPAGTDFVGGLWTLGGNGDATQRTGMAVHLYHANSSMDRVFSDADGELLIVPERGGLLLRTEFGLLHAEPGQVALVPRGVRFRVDLLDESARGYVCENYGAPFQLPDLGPIGANGLAAARDFKAPVAAYEDVEGPVEVVNKFCGNLWTATYDHSPLDVVAWHGNHVPYTYDLRRFNVLGTISYDHPDPSIFTVLTSPSDTPGLAGVDFVVFAPRWLVGEDTFRPPYFHRNVMSEYMGLIEGAYDAKAAGFVPGGGSLHNMMSAHGPDRETFDRASAAELRPQKIDDGLAFMFETRWPVTATAQAARAEHLQPAYDDVWQGLQRHFRPSD |
Interaction
Subunit
Hexamer; dimer of trimers.
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 16-40 | Disordered | ||||
Sequence: TGFGNEHASEAVPGALPEGRNSPQR |
Sequence similarities
Belongs to the homogentisate dioxygenase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length438
- Mass (Da)47,823
- Last updated2003-06-01 v1
- Checksum8E751EBA9B6F53BC
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BA000030 EMBL· GenBank· DDBJ | BAC74298.1 EMBL· GenBank· DDBJ | Genomic DNA |