Q81G67 · QUEE_BACCR
- Protein7-carboxy-7-deazaguanine synthase
- GenequeE
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids238 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
Catalytic activity
- 6-carboxy-5,6,7,8-tetrahydropterin + H+ = 7-carboxy-7-deazaguanine + NH4+
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
Note: Binds 1 S-adenosyl-L-methionine per subunit.
Pathway
Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 14-16 | substrate | ||||
Sequence: IQG | ||||||
Binding site | 29 | substrate | ||||
Sequence: R | ||||||
Binding site | 33 | [4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet | ||||
Sequence: C | ||||||
Binding site | 37 | [4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet | ||||
Sequence: C | ||||||
Binding site | 40 | [4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet | ||||
Sequence: C | ||||||
Binding site | 42 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 80 | substrate | ||||
Sequence: S | ||||||
Binding site | 82 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 126-128 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: SPK |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | carbon-nitrogen lyase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | S-adenosyl-L-methionine binding | |
Biological Process | queuosine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name7-carboxy-7-deazaguanine synthase
- EC number
- Short namesCDG synthase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Bacillus > Bacillus cereus group
Accessions
- Primary accessionQ81G67
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000416195 | 1-238 | 7-carboxy-7-deazaguanine synthase | |||
Sequence: MSKIPVLEIFGPTIQGEGMVVGQKTMFIRTAGCDYSCAWCDSAFTWDGSAKDQIRQMTPEDIWDELVAIGGENFSHVTISGGNPALLKNIEFLLSILKENGMRTAIETQGSKWQDWLLQIDEITISPKPPSSTMKTDFQRLDAIIQKLAGKDISLKVVVFDDHDFEYAVKMHERYPKVPFFLQVGNDDTKTVDDAMLIKKLLDKYEWLIDKAVNCKEMNDAKVLPQLHALVWGNKRGV |
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 20-234 | Radical SAM core | ||||
Sequence: VVGQKTMFIRTAGCDYSCAWCDSAFTWDGSAKDQIRQMTPEDIWDELVAIGGENFSHVTISGGNPALLKNIEFLLSILKENGMRTAIETQGSKWQDWLLQIDEITISPKPPSSTMKTDFQRLDAIIQKLAGKDISLKVVVFDDHDFEYAVKMHERYPKVPFFLQVGNDDTKTVDDAMLIKKLLDKYEWLIDKAVNCKEMNDAKVLPQLHALVWGN |
Sequence similarities
Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length238
- Mass (Da)26,872
- Last updated2003-06-01 v1
- Checksum48D1086D4B62FCC9
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE016877 EMBL· GenBank· DDBJ | AAP08325.1 EMBL· GenBank· DDBJ | Genomic DNA |