Q81EP4 · LDH1_BACCR

Function

function

Catalyzes the conversion of lactate to pyruvate.

Catalytic activity

Activity regulation

Allosterically activated by fructose 1,6-bisphosphate (FBP).

Pathway

Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.

Features

Showing features for binding site, active site.

131420406080100120140160180200220240260280300
TypeIDPosition(s)Description
Binding site16NAD+ (UniProtKB | ChEBI)
Binding site37NAD+ (UniProtKB | ChEBI)
Binding site42NAD+ (UniProtKB | ChEBI)
Binding site68NAD+ (UniProtKB | ChEBI)
Binding site82-83NAD+ (UniProtKB | ChEBI)
Binding site85substrate
Binding site91substrate
Binding site121-123NAD+ (UniProtKB | ChEBI)
Binding site123-126substrate
Binding site146NAD+ (UniProtKB | ChEBI)
Binding site151-154substrate
Binding site156beta-D-fructose 1,6-bisphosphate (UniProtKB | ChEBI); allosteric activator
Binding site171beta-D-fructose 1,6-bisphosphate (UniProtKB | ChEBI); allosteric activator
Active site178Proton acceptor
Binding site232substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionL-lactate dehydrogenase activity
Biological Processglycolytic process
Biological Processlactate metabolic process
Biological Processpyruvate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    L-lactate dehydrogenase 1
  • EC number
  • Short names
    L-LDH 1

Gene names

    • Name
      ldh1
    • Ordered locus names
      BC_1924

Organism names

Accessions

  • Primary accession
    Q81EP4

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001683211-314L-lactate dehydrogenase 1
Modified residue223Phosphotyrosine

Keywords

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the LDH/MDH superfamily. LDH family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    314
  • Mass (Da)
    34,789
  • Last updated
    2003-06-01 v1
  • Checksum
    19DC3B1C2083AB2B
MKKGINRVVLVGTGAVGCSYAYCMINQAVAEEFVLVDVNEAKAEGEAMDLSHAVPFAPAPTRVWKGSYEDCKDADLVVITAGLPQKPGETRLDLVEKNAKIFKQIVRSIMDSGFDGIFLIATNPVDILTYVTWKESGLPKERVIGSGTTLDSARFRYMLGEYFDIGPHNIHAYIIGEHGDTELPVWSHVSVGIQKLQTLLEKDNTYNQEDLDKIFINVRDAAYHIIERKGATYYGIGMSLLRVTKAILNDENSVLTVSAYLEGQYGQKDVYIGVPAVLNRGGVREILEVELSEDEELKFDHSVQVLKETMAPVL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE016877
EMBL· GenBank· DDBJ
AAP08895.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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