Q812F3 · HYAL5_MOUSE
- ProteinHyaluronidase-5
- GeneHyal5
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids526 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalyzes the hydrolysis of hyaluronan into smaller oligosaccharide fragments (PubMed:16330764, PubMed:16925524, PubMed:19605784).
Does not appear to be essential for fertilization (PubMed:19605784).
Does not appear to be essential for fertilization (PubMed:19605784).
Catalytic activity
pH Dependence
Optimum pH is 5-7.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 147 | Proton donor | ||||
Sequence: E |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | acrosomal membrane | |
Cellular Component | acrosomal vesicle | |
Cellular Component | external side of plasma membrane | |
Cellular Component | extracellular region | |
Cellular Component | plasma membrane | |
Molecular Function | hyalurononglucosaminidase activity | |
Biological Process | carbohydrate metabolic process | |
Biological Process | fusion of sperm to egg plasma membrane involved in single fertilization | |
Biological Process | hyaluronan catabolic process | |
Biological Process | penetration of zona pellucida |
Keywords
- Molecular function
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameHyaluronidase-5
- EC number
- Short namesHyal-5
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ812F3
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Lipid-anchor, GPI-anchor
Note: Located on the plasma and acrosomal membranes of acrosome-intact (AI) sperm and released during the acrosome reaction.
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
No visible phenotype. Viable and fertile.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 23 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-35 | |||||
Sequence: MRVLYFKHSFFRSLLKSNGLPQTLLVFLLIPCYLT | ||||||
Chain | PRO_0000441636 | 36-526 | Hyaluronidase-5 | |||
Sequence: VDFRAPPLIPDVPFLWAWNAPTESCFTRFNQPLDLGLFSLVGSPRKSATGQPVTIFYSDRLGLYPYIDDSQLIFNGGLPQLVSLKSHLEVAKTDILHYMPIDNVGLAVIDWEEWRPTWARNWKPKDIYRNKSIELVQQQNILLNFTEAVKWAKEEFEEAARHFMEETLRLGKSLRPNHLWGFYLFPDCYNNKFQVADYKGECPDIEKHRNDALFWIWEESTALYPSIYLKSSLKSSPQAALYVRNRVQEAIRVSKVKDPRNPLPIFVYFRIVFTDLTYQYLYEDDLVNTIGETIALGTSGMVMWGTLSLSQTMKSCLDLHDYLKTILNPYIINVTLAAKMCSQTLCQNQGVCSRKDWNSNDYLHLNPQNFQIHFVKHGKYEIRGNPTLENLLYFSQKFRCSCFAHLNCQERADIESVSTVSVCTLEDICINSLVISDKSELPKDWNRPYFVNSNQSDITSSATVSPCVPRKDVSGYLVVLSLYSQHLKYSL | ||||||
Disulfide bond | 60↔351 | |||||
Sequence: CFTRFNQPLDLGLFSLVGSPRKSATGQPVTIFYSDRLGLYPYIDDSQLIFNGGLPQLVSLKSHLEVAKTDILHYMPIDNVGLAVIDWEEWRPTWARNWKPKDIYRNKSIELVQQQNILLNFTEAVKWAKEEFEEAARHFMEETLRLGKSLRPNHLWGFYLFPDCYNNKFQVADYKGECPDIEKHRNDALFWIWEESTALYPSIYLKSSLKSSPQAALYVRNRVQEAIRVSKVKDPRNPLPIFVYFRIVFTDLTYQYLYEDDLVNTIGETIALGTSGMVMWGTLSLSQTMKSC | ||||||
Glycosylation | 165 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 179 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 223↔237 | |||||
Sequence: CYNNKFQVADYKGEC | ||||||
Disulfide bond | 376↔387 | |||||
Sequence: CSQTLCQNQGVC | ||||||
Disulfide bond | 381↔435 | |||||
Sequence: CQNQGVCSRKDWNSNDYLHLNPQNFQIHFVKHGKYEIRGNPTLENLLYFSQKFRC | ||||||
Disulfide bond | 437↔443 | |||||
Sequence: CFAHLNC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in testis, epididymal sperm and epididymides (at protein level) (PubMed:16330764, PubMed:19605784).
Expressed at highest levels in testis with lesser amounts in epididymal sperm (PubMed:16330764, PubMed:16925524, PubMed:19605784).
Expressed at highest levels in testis with lesser amounts in epididymal sperm (PubMed:16330764, PubMed:16925524, PubMed:19605784).
Developmental stage
Detected in the developing testis at postnatal day 20, with increasing levels through development.
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length526
- Mass (Da)60,808
- Last updated2003-06-01 v1
- Checksum94DF140035DB52C9
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB085680 EMBL· GenBank· DDBJ | BAC55071.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK133387 EMBL· GenBank· DDBJ | BAE21628.1 EMBL· GenBank· DDBJ | mRNA | ||
AC127559 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH466533 EMBL· GenBank· DDBJ | EDL13813.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC145992 EMBL· GenBank· DDBJ | AAI45993.1 EMBL· GenBank· DDBJ | mRNA | ||
BC145994 EMBL· GenBank· DDBJ | AAI45995.1 EMBL· GenBank· DDBJ | mRNA |