Q811V5 · Q811V5_RAT

  • Protein
    Sex-determining region Y protein
  • Gene
    Sry
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons.

Features

Showing features for dna binding.

117020406080100120140160
TypeIDPosition(s)Description
DNA binding5-73HMG box

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA binding

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Sex-determining region Y protein
  • Alternative names
    • Testis-determining factor

Gene names

    • Name
      Sry
    • Synonyms
      LOC103694550
      , Sry3B
      , Sry3b2

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • SHR/AKR
    • SHR/Akr
    • SHR/Crl
    • WKY/Akr
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q811V5

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

Structure

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain5-73HMG box
Region144-170Disordered

Sequence similarities

Belongs to the SRY family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    170
  • Mass (Da)
    20,588
  • Last updated
    2003-06-01 v1
  • MD5 Checksum
    CD99C673410DB1DFE8EAFDFEE36458B4
MEGHVKRPMNAFMVWSRGERRKLAQQNPSMQNSEISKQLGYQWKSLTEAEKRPFFQEAQRLKTLHREKYPNYKYQTHRRVKVPQRSYTLQREVASTKLYNLLQWDNNLHTIIYGQDWARAAHQSSKNQKSIYLQPVDIPTGYPLQQKQQHQQQQHVHLQQQQQQQQHQFH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY157996
EMBL· GenBank· DDBJ
AAO21705.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ168058
EMBL· GenBank· DDBJ
ACI29001.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ168064
EMBL· GenBank· DDBJ
ACI29007.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ168070
EMBL· GenBank· DDBJ
ACI29013.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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