Q811Q4 · ADA29_MOUSE
- ProteinDisintegrin and metalloproteinase domain-containing protein 29
- GeneAdam29
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids763 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | external side of plasma membrane | |
Cellular Component | plasma membrane | |
Cellular Component | sperm head plasma membrane | |
Molecular Function | metalloendopeptidase activity | |
Biological Process | male gonad development | |
Biological Process | proteolysis |
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameDisintegrin and metalloproteinase domain-containing protein 29
- Short namesADAM 29
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ811Q4
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 201-684 | Extracellular | ||||
Sequence: WTHTKIVELVVVVDKTLYDHYGNYTVMLSDLYSVINIVDTIYEVIGIKILLVGVEVWNKKNLIVIDDVSKSLRLYCRWKASNFLHRLKHDVSHLFIYRHLRGLSGIGSTGGICDPKRSCAVVTFIDRTLNLRAIGVAHHLGHNLGMKHDEDICKCSYSKCIMHMDSPPIPKFSNCSYNYFWSYTVKNTRCLMENMYTKDIFDRTRCGNGVVEDKEQCDCGSLRNCTNDLCCMSNCTLSTGSSCAFGLCCKNCQFLPSGTLCRKRDNICDLPEWCNGTSHECPDDAYVEDGIPCGVSAYCYEKQCNDRNEHCRQIFGQNAKTASVHCYREINTKGDRFGHCGLQGPTYIKCKSNDALCGRIQCDNVVQIPNMKDHSTIHFALVKNVSCWGTDYHTGTSLTDIGDVKDGTECEQNHICINRHCVHISTLDSNCTPAFCNYRGICNNKHHCHCNFHWDPPNCMIRGHGGSVDSGLPPKTNKKKHFFY | ||||||
Transmembrane | 685-705 | Helical | ||||
Sequence: LLLLQLIILACLLSCLLWLLF | ||||||
Topological domain | 706-763 | Cytoplasmic | ||||
Sequence: NIKGSKRKPQVQPTPVKTKKVSKKVPSQKPSPVPSPSLPQLRMPSRSASPTSSIKSTN |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, propeptide, glycosylation, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-31 | |||||
Sequence: MNMIEALLSMRVLFLTQVFGIFLCFPGLTKA | ||||||
Propeptide | PRO_0000373775 | 32-200 | ||||
Sequence: GHLHYHSSIEVVIPMKVTEKTRGMNLPNWISYSLKLGGQRYIIHMKIKNLFLTRHLPVFTYSDQDSLLEDYPFVQDDCYYQGYVEGDSESLVSLSSCFGGFHGLLEINNIVYEIMPKKFSRKFEHLVYKVDINKTESRGSSLMQDNITCQVELQKSGNPILKQSSFEDW | ||||||
Glycosylation | 164 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 177 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Chain | PRO_0000373776 | 201-763 | Disintegrin and metalloproteinase domain-containing protein 29 | |||
Sequence: WTHTKIVELVVVVDKTLYDHYGNYTVMLSDLYSVINIVDTIYEVIGIKILLVGVEVWNKKNLIVIDDVSKSLRLYCRWKASNFLHRLKHDVSHLFIYRHLRGLSGIGSTGGICDPKRSCAVVTFIDRTLNLRAIGVAHHLGHNLGMKHDEDICKCSYSKCIMHMDSPPIPKFSNCSYNYFWSYTVKNTRCLMENMYTKDIFDRTRCGNGVVEDKEQCDCGSLRNCTNDLCCMSNCTLSTGSSCAFGLCCKNCQFLPSGTLCRKRDNICDLPEWCNGTSHECPDDAYVEDGIPCGVSAYCYEKQCNDRNEHCRQIFGQNAKTASVHCYREINTKGDRFGHCGLQGPTYIKCKSNDALCGRIQCDNVVQIPNMKDHSTIHFALVKNVSCWGTDYHTGTSLTDIGDVKDGTECEQNHICINRHCVHISTLDSNCTPAFCNYRGICNNKHHCHCNFHWDPPNCMIRGHGGSVDSGLPPKTNKKKHFFYLLLLQLIILACLLSCLLWLLFNIKGSKRKPQVQPTPVKTKKVSKKVPSQKPSPVPSPSLPQLRMPSRSASPTSSIKSTN | ||||||
Glycosylation | 223 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 313↔390 | |||||
Sequence: CDPKRSCAVVTFIDRTLNLRAIGVAHHLGHNLGMKHDEDICKCSYSKCIMHMDSPPIPKFSNCSYNYFWSYTVKNTRC | ||||||
Disulfide bond | 353↔375 | |||||
Sequence: CKCSYSKCIMHMDSPPIPKFSNC | ||||||
Disulfide bond | 355↔360 | |||||
Sequence: CSYSKC | ||||||
Glycosylation | 374 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 424 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 434 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 461↔481 | |||||
Sequence: CRKRDNICDLPEWCNGTSHEC | ||||||
Glycosylation | 475 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 584 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 631↔642 | |||||
Sequence: CTPAFCNYRGIC | ||||||
Disulfide bond | 636↔648 | |||||
Sequence: CNYRGICNNKHHC | ||||||
Disulfide bond | 650↔659 | |||||
Sequence: CNFHWDPPNC |
Keywords
- PTM
Proteomic databases
PTM databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 205-396 | Peptidase M12B | ||||
Sequence: KIVELVVVVDKTLYDHYGNYTVMLSDLYSVINIVDTIYEVIGIKILLVGVEVWNKKNLIVIDDVSKSLRLYCRWKASNFLHRLKHDVSHLFIYRHLRGLSGIGSTGGICDPKRSCAVVTFIDRTLNLRAIGVAHHLGHNLGMKHDEDICKCSYSKCIMHMDSPPIPKFSNCSYNYFWSYTVKNTRCLMENMY | ||||||
Domain | 403-489 | Disintegrin | ||||
Sequence: RTRCGNGVVEDKEQCDCGSLRNCTNDLCCMSNCTLSTGSSCAFGLCCKNCQFLPSGTLCRKRDNICDLPEWCNGTSHECPDDAYVED | ||||||
Domain | 631-660 | EGF-like | ||||
Sequence: CTPAFCNYRGICNNKHHCHCNFHWDPPNCM | ||||||
Region | 712-763 | Disordered | ||||
Sequence: RKPQVQPTPVKTKKVSKKVPSQKPSPVPSPSLPQLRMPSRSASPTSSIKSTN | ||||||
Compositional bias | 745-763 | Polar residues | ||||
Sequence: QLRMPSRSASPTSSIKSTN |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length763
- Mass (Da)86,445
- Last updated2003-06-01 v1
- ChecksumF9EF082C3BFBBA80
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
G3X9B5 | G3X9B5_MOUSE | Adam29 | 763 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 745-763 | Polar residues | ||||
Sequence: QLRMPSRSASPTSSIKSTN |
Keywords
- Technical term