Q810F8 · TBX10_MOUSE

  • Protein
    T-box transcription factor TBX10
  • Gene
    Tbx10
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Probable transcriptional regulator involved in developmental processes.

Features

Showing features for dna binding.

138550100150200250300350
TypeIDPosition(s)Description
DNA binding69-252T-box

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromatin
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processcell fate specification
Biological Processpositive regulation of DNA-templated transcription
Biological Processregulation of transcription by RNA polymerase II

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    T-box transcription factor TBX10
  • Short names
    T-box protein 10
  • Alternative names
    • MmTBX7
    • T-box protein 13

Gene names

    • Name
      Tbx10
    • Synonyms
      Tbx13, Tbx7

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • C3H/HeJ
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q810F8
  • Secondary accessions
    • O54841
    • Q32MF8
    • Q6QH75

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Involvement in disease

  • Defects in Tbx10 are the cause of a cleft lip and palate (CL/P) phenotype called Dancer (Dc). The defect is caused by a gain of function

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 24 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001844421-385T-box transcription factor TBX10

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region283-310Disordered
Region328-359Disordered

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q810F8-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    385
  • Mass (Da)
    42,407
  • Last updated
    2003-06-01 v1
  • Checksum
    0F0C0ABBF0881B48
MAVFLSAGLGVLAPPETCPHPETSTSWESRLGTRFPSGSCTMSTEAQAMAEPTGQGPKNPRVSSVMVQLEMKPLWEEFNQLGTEMIVTKAGRRMFPTFQVKILGMDTLADYALLMDFIPLDDKRYRYAFHSSAWLVAGKADPATPGRVHFHPDSPAKGAQWMRQIVSFDKLKLTNNLMDDNGHIILNSMHRYQPRFHVVFVDPRKDSARYAQENFKSFVFTETQFTAVTAYQNHRITQLKIASNPFAKGFREADPDSWPVTPRPLLSIPARSRSSLSPCLLKGSAEREKDTSKASASSSRTPTQPHNQLLPAPDVLLAPATYRPLPYQNLYPGSPSRAGPPRARLAPYPLPNISTAGDQEDPTLAAGLGLLPTSALCLVSNQASQ

Q810F8-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0113051-41in isoform 2
Sequence conflict93in Ref. 4; AAC40116
Sequence conflict186in Ref. 4; AAC40116

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY229976
EMBL· GenBank· DDBJ
AAO73482.1
EMBL· GenBank· DDBJ
mRNA
AY542280
EMBL· GenBank· DDBJ
AAS55456.1
EMBL· GenBank· DDBJ
mRNA
BC109150
EMBL· GenBank· DDBJ
AAI09151.1
EMBL· GenBank· DDBJ
mRNA
BC109151
EMBL· GenBank· DDBJ
AAI09152.1
EMBL· GenBank· DDBJ
mRNA
AF013283
EMBL· GenBank· DDBJ
AAC40116.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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