Q810B9 · SLIK3_MOUSE
- ProteinSLIT and NTRK-like protein 3
- GeneSlitrk3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids980 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Suppresses neurite outgrowth.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell surface | |
Cellular Component | GABA-ergic synapse | |
Cellular Component | membrane | |
Cellular Component | postsynaptic density membrane | |
Cellular Component | postsynaptic membrane | |
Biological Process | axonogenesis | |
Biological Process | gephyrin clustering involved in postsynaptic density assembly | |
Biological Process | neurotransmitter-gated ion channel clustering | |
Biological Process | positive regulation of synapse assembly | |
Biological Process | postsynaptic density assembly | |
Biological Process | regulation of presynapse assembly | |
Biological Process | synaptic membrane adhesion | |
Biological Process | synaptic transmission, GABAergic | |
Biological Process | terminal button organization |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSLIT and NTRK-like protein 3
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ810B9
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 30-655 | Extracellular | ||||
Sequence: TPIPLIEDSEEIDEPCFDPCYCEVKESLFHIHCDSKGFTNISQITEFWSRPFKLYLQRNSMRRLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPVLPTNLFKAVSLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNCTCEIVQLKSWLERIPYTALVGDITCETPFHFHGKDLREIKKTELCPLLSDSEVEASLGIPHLSSSKENAWPTKPSSMLSSVHFTASSVEYKSSNKQPKPTKQPRTPRPPSTSQALYPGPNQPPIAPYQTRPPIPIICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFLYLPVAGVLEHLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRTPENLTHRDVRTIELEVLCPEMLHIAQPGPSPPQPGDYHPNGGPTSASPYEFSPPGGPVPLS | ||||||
Transmembrane | 656-676 | Helical | ||||
Sequence: VLILSLLVLFFSAVFVAAGLF | ||||||
Topological domain | 677-980 | Cytoplasmic | ||||
Sequence: AYVLRRRRKKLPFRSKRQEGVDLTGIQMQCHRLFEDSGGNSGGSGGGGRPTLSSPEKAPPVGHVYEYIPHPVTQMCNNPIYKPREEEEVAASAAQDTGATDRGGPGTQPTGMAEVLLGSEQFAETPKENHSNYRTLLEKEKEWALAVSNSQLNTIVTVNHHHPHPHHSAVGGVSGVGGGTGGDLAGFRHHEKNGGVVLFPPGGGCGGGSLLLDRERPQPAPCTVGFVDCLYGTVPKLKELHVHPPGMQYPDLQQDARLKETLLFSAGKGFTDHQTPKSDYLDLRAKLQTKPDYLEVLEKTAYRF |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-27 | |||||
Sequence: MMKPSIAEMLHRGRMLWIILLSTIALG | ||||||
Chain | PRO_0000032678 | 28-980 | SLIT and NTRK-like protein 3 | |||
Sequence: WTTPIPLIEDSEEIDEPCFDPCYCEVKESLFHIHCDSKGFTNISQITEFWSRPFKLYLQRNSMRRLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPVLPTNLFKAVSLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNCTCEIVQLKSWLERIPYTALVGDITCETPFHFHGKDLREIKKTELCPLLSDSEVEASLGIPHLSSSKENAWPTKPSSMLSSVHFTASSVEYKSSNKQPKPTKQPRTPRPPSTSQALYPGPNQPPIAPYQTRPPIPIICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFLYLPVAGVLEHLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRTPENLTHRDVRTIELEVLCPEMLHIAQPGPSPPQPGDYHPNGGPTSASPYEFSPPGGPVPLSVLILSLLVLFFSAVFVAAGLFAYVLRRRRKKLPFRSKRQEGVDLTGIQMQCHRLFEDSGGNSGGSGGGGRPTLSSPEKAPPVGHVYEYIPHPVTQMCNNPIYKPREEEEVAASAAQDTGATDRGGPGTQPTGMAEVLLGSEQFAETPKENHSNYRTLLEKEKEWALAVSNSQLNTIVTVNHHHPHPHHSAVGGVSGVGGGTGGDLAGFRHHEKNGGVVLFPPGGGCGGGSLLLDRERPQPAPCTVGFVDCLYGTVPKLKELHVHPPGMQYPDLQQDARLKETLLFSAGKGFTDHQTPKSDYLDLRAKLQTKPDYLEVLEKTAYRF | ||||||
Glycosylation | 69 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 597 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Broadly expressed in embryonic brain with highest expression in cortical plate, pyramidal cell layer of the hippocampus, thalamus and hypothalamus.
Gene expression databases
Structure
Family & Domains
Features
Showing features for repeat, domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 79-100 | LRR 1 | ||||
Sequence: RPFKLYLQRNSMRRLYTNSFLH | ||||||
Repeat | 103-124 | LRR 2 | ||||
Sequence: NAVSINLGNNALQDIQTGAFNG | ||||||
Repeat | 127-148 | LRR 3 | ||||
Sequence: ILKRLYLHENKLDVFRNDTFLG | ||||||
Repeat | 151-172 | LRR 4 | ||||
Sequence: SLEYLQADYNVIKRIESGAFRN | ||||||
Repeat | 175-196 | LRR 5 | ||||
Sequence: KLRVLILNDNLIPVLPTNLFKA | ||||||
Repeat | 198-219 | LRR 6 | ||||
Sequence: SLTHLDLRGNRLKVLFYRGMLD | ||||||
Domain | 233-284 | LRRCT 1 | ||||
Sequence: NPWNCTCEIVQLKSWLERIPYTALVGDITCETPFHFHGKDLREIKKTELCPL | ||||||
Region | 326-361 | Disordered | ||||
Sequence: EYKSSNKQPKPTKQPRTPRPPSTSQALYPGPNQPPI | ||||||
Compositional bias | 338-361 | Pro residues | ||||
Sequence: KQPRTPRPPSTSQALYPGPNQPPI | ||||||
Domain | 365-407 | LRRNT | ||||
Sequence: QTRPPIPIICPTGCTCNLHINDLGLTVNCKERGFNNISELLPR | ||||||
Repeat | 410-431 | LRR 7 | ||||
Sequence: NAKKLYLSSNLIQKIYRSDFWN | ||||||
Repeat | 434-455 | LRR 8 | ||||
Sequence: SLDLLHLGNNRISYVQDGAFIN | ||||||
Repeat | 458-479 | LRR 9 | ||||
Sequence: NLKSLFLNGNDIEKLTPGMFRG | ||||||
Repeat | 482-503 | LRR 10 | ||||
Sequence: SLHYLYFEFNVIREIQPAAFSL | ||||||
Repeat | 506-527 | LRR 11 | ||||
Sequence: NLKLLFLNNNLLRTLPTDAFAG | ||||||
Repeat | 529-550 | LRR 12 | ||||
Sequence: SLARLNLRKNYFLYLPVAGVLE | ||||||
Domain | 563-614 | LRRCT 2 | ||||
Sequence: NPWDCTCDLVPFKQWIETISSVSVVGDVLCRTPENLTHRDVRTIELEVLCPE | ||||||
Region | 622-644 | Disordered | ||||
Sequence: GPSPPQPGDYHPNGGPTSASPYE | ||||||
Region | 709-735 | Disordered | ||||
Sequence: LFEDSGGNSGGSGGGGRPTLSSPEKAP | ||||||
Region | 762-785 | Disordered | ||||
Sequence: EEEVAASAAQDTGATDRGGPGTQP |
Sequence similarities
Belongs to the SLITRK family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length980
- Mass (Da)109,406
- Last updated2011-07-27 v2
- ChecksumC7671B133C601314
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 338-361 | Pro residues | ||||
Sequence: KQPRTPRPPSTSQALYPGPNQPPI | ||||||
Sequence conflict | 636 | in Ref. 1; BAC67206 | ||||
Sequence: G → R | ||||||
Sequence conflict | 690 | in Ref. 1; BAC67206 | ||||
Sequence: R → K | ||||||
Sequence conflict | 721-723 | in Ref. 1; BAC67206 | ||||
Sequence: GGG → EGE | ||||||
Sequence conflict | 732 | in Ref. 1; BAC67206 | ||||
Sequence: E → K | ||||||
Sequence conflict | 735 | in Ref. 1; BAC67206 | ||||
Sequence: P → L | ||||||
Sequence conflict | 977 | in Ref. 1; BAC67206 | ||||
Sequence: A → T |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB097572 EMBL· GenBank· DDBJ | BAC67206.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK158856 EMBL· GenBank· DDBJ | BAE34696.1 EMBL· GenBank· DDBJ | mRNA | ||
CH466547 EMBL· GenBank· DDBJ | EDL15486.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC066059 EMBL· GenBank· DDBJ | AAH66059.1 EMBL· GenBank· DDBJ | mRNA |