Q810B8 · SLIK4_MOUSE
- ProteinSLIT and NTRK-like protein 4
- GeneSlitrk4
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids837 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
It is involved in synaptogenesis and promotes synapse differentiation (By similarity).
Suppresses neurite outgrowth (PubMed:14550773).
Suppresses neurite outgrowth (PubMed:14550773).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | glutamatergic synapse | |
Cellular Component | membrane | |
Cellular Component | plasma membrane | |
Biological Process | axonogenesis | |
Biological Process | positive regulation of synapse assembly | |
Biological Process | regulation of presynapse assembly |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSLIT and NTRK-like protein 4
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ810B8
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 19-618 | Extracellular | ||||
Sequence: DSDISVEICNVCSCVSVENVLYVNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFVNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQQENGFTTPNGHTTQTTLHRLVTKPPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTPCPVPCFCKTHPSDLGLSVNCQEKNIQSMSELTPKPLNAKKLHVNGNNIKDVDISDFTEFEGLDLLHLGSNQITLIKGEVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEILAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWLEKLNDGIVVKELKCETPVQFANIELKSLKNEILCPKLLNKPSATFTSPAPAITFTTPLGPIRSPPGGPVPLS | ||||||
Transmembrane | 619-639 | Helical | ||||
Sequence: ILILSILVVLILTVFVAFCLL | ||||||
Topological domain | 640-837 | Cytoplasmic | ||||
Sequence: VFVLRRNKKPTVKHEGLGNSECGSMQLQLRKHDHKTNKKDGLSTEAFIPQTIEQMSKSHTCGLKESETGFMFSDPPGQKVMMRNAADKDKDLLHVDTRKRLSTIDELDELFPSRDSNVFIQNFLESKKEYNSIGVSGFEIRYPEKQQDKKNKKSLIGGNHSKIVVEQRKSEYFELKAKLQSSPDYLQVLEEQTALNKI |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-18 | |||||
Sequence: MFLWLFLIVSALISSTNA | ||||||
Chain | PRO_0000032680 | 19-837 | SLIT and NTRK-like protein 4 | |||
Sequence: DSDISVEICNVCSCVSVENVLYVNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFVNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQQENGFTTPNGHTTQTTLHRLVTKPPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTPCPVPCFCKTHPSDLGLSVNCQEKNIQSMSELTPKPLNAKKLHVNGNNIKDVDISDFTEFEGLDLLHLGSNQITLIKGEVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEILAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWLEKLNDGIVVKELKCETPVQFANIELKSLKNEILCPKLLNKPSATFTSPAPAITFTTPLGPIRSPPGGPVPLSILILSILVVLILTVFVAFCLLVFVLRRNKKPTVKHEGLGNSECGSMQLQLRKHDHKTNKKDGLSTEAFIPQTIEQMSKSHTCGLKESETGFMFSDPPGQKVMMRNAADKDKDLLHVDTRKRLSTIDELDELFPSRDSNVFIQNFLESKKEYNSIGVSGFEIRYPEKQQDKKNKKSLIGGNHSKIVVEQRKSEYFELKAKLQSSPDYLQVLEEQTALNKI | ||||||
Glycosylation | 81 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 325 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 423 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
In the adult, significant expression is detected only in the brain. Broadly expressed in embryonic brain with highest expression in subventricular zone, subplate, cortical plate, pyramidal cell layer of hippocampus, thalamus and hypothalamus.
Developmental stage
In the embryo, expressed from day 10-12 and continues through later gestational development and into adulthood.
Gene expression databases
Structure
Family & Domains
Features
Showing features for repeat, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 60-81 | LRR 1 | ||||
Sequence: NFYHLNFQNNFLNILYPNTFVN | ||||||
Repeat | 84-105 | LRR 2 | ||||
Sequence: HAVSLHLGNNKLQNIEGGAFLG | ||||||
Repeat | 108-129 | LRR 3 | ||||
Sequence: ALKQLHLNNNELKILRADTFLG | ||||||
Repeat | 132-153 | LRR 4 | ||||
Sequence: NLEYLQADYNLIKYIERGAFNK | ||||||
Repeat | 156-177 | LRR 5 | ||||
Sequence: KLKVLILNDNLISFLPDNIFRF | ||||||
Repeat | 179-200 | LRR 6 | ||||
Sequence: SLTHLDIRGNRIQKLPYIGVLE | ||||||
Domain | 213-264 | LRRCT 1 | ||||
Sequence: NPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCPM | ||||||
Domain | 333-375 | LRRNT | ||||
Sequence: QTRVPPLTPCPVPCFCKTHPSDLGLSVNCQEKNIQSMSELTPK | ||||||
Repeat | 378-399 | LRR 7 | ||||
Sequence: NAKKLHVNGNNIKDVDISDFTE | ||||||
Repeat | 402-423 | LRR 8 | ||||
Sequence: GLDLLHLGSNQITLIKGEVFHN | ||||||
Repeat | 426-447 | LRR 9 | ||||
Sequence: NLRRLYLNGNQIERLYPEIFSG | ||||||
Repeat | 450-471 | LRR 10 | ||||
Sequence: NLQYLYLEYNLIKEILAGTFDS | ||||||
Repeat | 474-495 | LRR 11 | ||||
Sequence: NLQLLYLNNNLLKSLPVYIFSG | ||||||
Repeat | 497-518 | LRR 12 | ||||
Sequence: PLARLNLRNNKFMYLPVSGVLD | ||||||
Domain | 531-582 | LRRCT 2 | ||||
Sequence: NPWDCTCDLVALKLWLEKLNDGIVVKELKCETPVQFANIELKSLKNEILCPK |
Sequence similarities
Belongs to the SLITRK family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length837
- Mass (Da)94,538
- Last updated2004-03-29 v2
- ChecksumCCD3897E86B95ABC
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
B1AU89 | B1AU89_MOUSE | Slitrk4 | 110 |
Sequence caution
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 429 | in Ref. 2; BAC27786 | ||||
Sequence: R → G |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB097573 EMBL· GenBank· DDBJ | BAC67207.1 EMBL· GenBank· DDBJ | Genomic DNA | Different initiation | |
AK032263 EMBL· GenBank· DDBJ | BAC27786.1 EMBL· GenBank· DDBJ | mRNA | ||
AK039763 EMBL· GenBank· DDBJ | BAC30442.1 EMBL· GenBank· DDBJ | mRNA | ||
AK053065 EMBL· GenBank· DDBJ | BAC35254.1 EMBL· GenBank· DDBJ | mRNA |