Q810B8 · SLIK4_MOUSE

  • Protein
    SLIT and NTRK-like protein 4
  • Gene
    Slitrk4
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

It is involved in synaptogenesis and promotes synapse differentiation (By similarity).
Suppresses neurite outgrowth (PubMed:14550773).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentglutamatergic synapse
Cellular Componentmembrane
Cellular Componentplasma membrane
Biological Processaxonogenesis
Biological Processpositive regulation of synapse assembly
Biological Processregulation of presynapse assembly

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    SLIT and NTRK-like protein 4

Gene names

    • Name
      Slitrk4

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q810B8
  • Secondary accessions
    • Q8BL56
    • Q8BWB0
    • Q8BYG4
    • Q8C056

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Single-pass type I membrane protein
Cell membrane

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain19-618Extracellular
Transmembrane619-639Helical
Topological domain640-837Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation.

TypeIDPosition(s)Description
Signal1-18
ChainPRO_000003268019-837SLIT and NTRK-like protein 4
Glycosylation81N-linked (GlcNAc...) asparagine
Glycosylation325N-linked (GlcNAc...) asparagine
Glycosylation423N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

In the adult, significant expression is detected only in the brain. Broadly expressed in embryonic brain with highest expression in subventricular zone, subplate, cortical plate, pyramidal cell layer of hippocampus, thalamus and hypothalamus.

Developmental stage

In the embryo, expressed from day 10-12 and continues through later gestational development and into adulthood.

Gene expression databases

Interaction

Subunit

Interacts (via LRR 1 and 2 repeats) with PTPRD (via extracellular domain).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for repeat, domain.

TypeIDPosition(s)Description
Repeat60-81LRR 1
Repeat84-105LRR 2
Repeat108-129LRR 3
Repeat132-153LRR 4
Repeat156-177LRR 5
Repeat179-200LRR 6
Domain213-264LRRCT 1
Domain333-375LRRNT
Repeat378-399LRR 7
Repeat402-423LRR 8
Repeat426-447LRR 9
Repeat450-471LRR 10
Repeat474-495LRR 11
Repeat497-518LRR 12
Domain531-582LRRCT 2

Sequence similarities

Belongs to the SLITRK family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    837
  • Mass (Da)
    94,538
  • Last updated
    2004-03-29 v2
  • Checksum
    CCD3897E86B95ABC
MFLWLFLIVSALISSTNADSDISVEICNVCSCVSVENVLYVNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFVNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQQENGFTTPNGHTTQTTLHRLVTKPPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTPCPVPCFCKTHPSDLGLSVNCQEKNIQSMSELTPKPLNAKKLHVNGNNIKDVDISDFTEFEGLDLLHLGSNQITLIKGEVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEILAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWLEKLNDGIVVKELKCETPVQFANIELKSLKNEILCPKLLNKPSATFTSPAPAITFTTPLGPIRSPPGGPVPLSILILSILVVLILTVFVAFCLLVFVLRRNKKPTVKHEGLGNSECGSMQLQLRKHDHKTNKKDGLSTEAFIPQTIEQMSKSHTCGLKESETGFMFSDPPGQKVMMRNAADKDKDLLHVDTRKRLSTIDELDELFPSRDSNVFIQNFLESKKEYNSIGVSGFEIRYPEKQQDKKNKKSLIGGNHSKIVVEQRKSEYFELKAKLQSSPDYLQVLEEQTALNKI

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
B1AU89B1AU89_MOUSESlitrk4110

Sequence caution

The sequence BAC67207.1 differs from that shown. Reason: Erroneous initiation

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict429in Ref. 2; BAC27786

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB097573
EMBL· GenBank· DDBJ
BAC67207.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation
AK032263
EMBL· GenBank· DDBJ
BAC27786.1
EMBL· GenBank· DDBJ
mRNA
AK039763
EMBL· GenBank· DDBJ
BAC30442.1
EMBL· GenBank· DDBJ
mRNA
AK053065
EMBL· GenBank· DDBJ
BAC35254.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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