Q80ZE5 · PAQR8_MOUSE

  • Protein
    Membrane progestin receptor beta
  • Gene
    Paqr8
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway (By similarity).
May be involved in oocyte maturation (PubMed:12601167).
Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (By similarity).

Miscellaneous

Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentGolgi apparatus
Cellular Componentplasma membrane
Molecular Functionnuclear steroid receptor activity
Molecular Functionsteroid binding
Biological Processoogenesis
Biological Processresponse to steroid hormone

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Membrane progestin receptor beta
  • Short names
    mPR beta
  • Alternative names
    • Lysosomal membrane protein in brain 1
    • Membrane progesterone P4 receptor beta
    • Membrane progesterone receptor beta
    • Progesterone and adipoQ receptor family member 8
    • Progestin and adipoQ receptor family member 8
    • Progestin and adipoQ receptor family member VIII

Gene names

    • Name
      Paqr8
    • Synonyms
      Mprb

Organism names

  • Taxonomic identifier
  • Strains
    • CD-1
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q80ZE5
  • Secondary accessions
    • Q3UHI5
    • Q8C891
    • Q8CCW9
    • Q9DA71

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Note: Colocalizes with a lysosomal protein CTSD/cathepsin D.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-76Cytoplasmic
Transmembrane77-97Helical; Name=1
Topological domain98-111Extracellular
Transmembrane112-132Helical; Name=2
Topological domain133-173Cytoplasmic
Transmembrane174-194Helical; Name=3
Topological domain195-213Extracellular
Transmembrane214-234Helical; Name=4
Topological domain235-243Cytoplasmic
Transmembrane244-264Helical; Name=5
Topological domain265-283Extracellular
Transmembrane284-304Helical; Name=6
Topological domain305-315Cytoplasmic
Transmembrane316-336Helical; Name=7
Topological domain337-354Extracellular

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002188411-354Membrane progestin receptor beta

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in brain and testis.

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Belongs to the ADIPOR family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    354
  • Mass (Da)
    40,430
  • Last updated
    2004-08-16 v2
  • Checksum
    14544CBB3338B538
MTTAILERLSTLSMSGQQLRRLPKILEEGLPKMPCTVPETDVPQLFREPYIHAGYRPTGHEWRYYFFSLFQKHNEVVNVWTHLLAALAVLLRFWAFVEAGALQWASPHTLPLLLFILSSITYLTCSLLAHLLQSKSELSHYTFYFVDYVGVSVYQYGSALAHFFYSSDQAWYELFWIFFLPAAAFCGWLSCAGCCYAKYRYRRPYPVMRKICQVVPAGLAFVLDISPVAHRVALCHLAGCQEQAAWYHTLQILFFLVSAYFFSCPVPEKYFPGSCDIVGHGHQIFHAFLSVCTLSQLEAILLDYQGRHEIFLQRHGPLSVYSACLSFFVLAACSAATATLLRHKVKDRLIKKDS

Sequence caution

The sequence BAC27629.1 differs from that shown. Reason: Frameshift

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict41in Ref. 3; AAR08385/BAC33221
Sequence conflict116in Ref. 1; AAO47230
Sequence conflict177in Ref. 1; AAO47230
Sequence conflict339in Ref. 1; AAO47230

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF313617
EMBL· GenBank· DDBJ
AAO47230.1
EMBL· GenBank· DDBJ
mRNA
AY424297
EMBL· GenBank· DDBJ
AAR08385.1
EMBL· GenBank· DDBJ
mRNA
AK006107
EMBL· GenBank· DDBJ
BAB24412.1
EMBL· GenBank· DDBJ
mRNA
AK029772
EMBL· GenBank· DDBJ
BAC26609.1
EMBL· GenBank· DDBJ
mRNA
AK031969
EMBL· GenBank· DDBJ
BAC27629.1
EMBL· GenBank· DDBJ
mRNA Frameshift
AK048045
EMBL· GenBank· DDBJ
BAC33221.1
EMBL· GenBank· DDBJ
mRNA
AK147376
EMBL· GenBank· DDBJ
BAE27872.1
EMBL· GenBank· DDBJ
mRNA
BC059813
EMBL· GenBank· DDBJ
AAH59813.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp