Q80XT4 · Q80XT4_MOUSE
- ProteinDihydropyrimidine dehydrogenase [NADP(+)]
- GeneDpyd
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids879 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.
Catalytic activity
- 5,6-dihydrouracil + NADP+ = H+ + NADPH + uracil
Cofactor
Protein has several cofactor binding sites:
Note: Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.
Pathway
Amino-acid biosynthesis; beta-alanine biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | dihydropyrimidine dehydrogenase (NADP+) activity | |
Biological Process | beta-alanine biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDihydropyrimidine dehydrogenase [NADP(+)]
- EC number
- Short namesDHPDHase ; DPD
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ80XT4
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 798-830 | 4Fe-4S ferredoxin-type | ||||
Sequence: VVALIDEEMCINCGKCYMTCNDSGYQAIQFDPE | ||||||
Domain | 832-861 | 4Fe-4S ferredoxin-type | ||||
Sequence: HLPTVSDTCTGCTLCLSVCPIMDCIRMVSR |
Sequence similarities
Belongs to the dihydropyrimidine dehydrogenase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length879
- Mass (Da)95,412
- Last updated2003-06-01 v1
- ChecksumA4F917B967AD1E62
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: E |