Q80XC3 · US6NL_MOUSE
- ProteinUSP6 N-terminal-like protein
- GeneUsp6nl
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids819 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasmic vesicle | |
Cellular Component | Golgi apparatus | |
Cellular Component | plasma membrane | |
Molecular Function | GTPase activator activity | |
Molecular Function | small GTPase binding | |
Biological Process | Golgi organization | |
Biological Process | plasma membrane to endosome transport | |
Biological Process | regulation of Golgi organization | |
Biological Process | retrograde transport, plasma membrane to Golgi | |
Biological Process | virion assembly |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUSP6 N-terminal-like protein
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ80XC3
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Modified residue | 1 | N-acetylmethionine | ||||
Sequence: M | ||||||
Chain | PRO_0000208057 | 1-819 | USP6 N-terminal-like protein | |||
Sequence: MNSDQDVALKLAQERAEIVAKYDRGREGAEIEPWEDADYLVYKVTDRFGFLHEEELPYHNAAADRQKQLEIERTSKWLKMLKKWERYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFRLNLRIWDIYIFEGERVLTAMSYTILKLHKKHLMKLSMEELVEFLQETLAKDFFFEDDFVIEQLQVSMAELKRAKLDLPEPGKEDEYPKKPLGQLPPESACVNHLSNGQRSVGRPSPKTSSRREDGSPRKNHEHSPVHHSRNGTPERAGQSRRKSVDEGSKNLKHEAESQRKPSPGMQDSSRHYNHAAANQNSNAISNVRKEFMPKWRKPSDASAIERTTKYAVEGKSHSALPALPVAIPGSAETRLPNSRQKMKALDGGEGKRGSNASQYDNVPGGESEHGASAEEGPERTHPHSPRKHPEPSPSPPKVPNKFTFKVQPPSHVRYPPQLPEEDHRAAYPPSYSNPPVYHGNSPKHVPTAHSGFVSTQISPRPQINPSRRPYGSSLSVDTSPEKAYSRPTPVVLPSSRIEVLPIDMGARGYGSSGSPKNGQFILPPVDYLPENRKWSEVSYTYRPEMHGQSWTRDAHRSHLSNLPNYAAFQHIPFQAHGLPEVSVDSPVRYKMSAAVEDASPPGYPYAGPSPSAHHYRNGEGLSVQESVLL | ||||||
Modified residue | 389 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 394 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 398 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 544 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 547 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 574 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 631 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 644 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 648 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 665 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 669 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 704 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 717 | Phosphotyrosine | ||||
Sequence: Y |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 100-292 | Rab-GAP TBC | ||||
Sequence: GIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFRLNLRIWDIYIFEG | ||||||
Compositional bias | 355-369 | Basic and acidic residues | ||||
Sequence: DLPEPGKEDEYPKKP | ||||||
Region | 355-498 | Disordered | ||||
Sequence: DLPEPGKEDEYPKKPLGQLPPESACVNHLSNGQRSVGRPSPKTSSRREDGSPRKNHEHSPVHHSRNGTPERAGQSRRKSVDEGSKNLKHEAESQRKPSPGMQDSSRHYNHAAANQNSNAISNVRKEFMPKWRKPSDASAIERTT | ||||||
Compositional bias | 378-394 | Polar residues | ||||
Sequence: ACVNHLSNGQRSVGRPS | ||||||
Compositional bias | 395-450 | Basic and acidic residues | ||||
Sequence: PKTSSRREDGSPRKNHEHSPVHHSRNGTPERAGQSRRKSVDEGSKNLKHEAESQRK | ||||||
Compositional bias | 451-477 | Polar residues | ||||
Sequence: PSPGMQDSSRHYNHAAANQNSNAISNV | ||||||
Region | 513-678 | Disordered | ||||
Sequence: LPVAIPGSAETRLPNSRQKMKALDGGEGKRGSNASQYDNVPGGESEHGASAEEGPERTHPHSPRKHPEPSPSPPKVPNKFTFKVQPPSHVRYPPQLPEEDHRAAYPPSYSNPPVYHGNSPKHVPTAHSGFVSTQISPRPQINPSRRPYGSSLSVDTSPEKAYSRPT | ||||||
Compositional bias | 561-580 | Basic and acidic residues | ||||
Sequence: ASAEEGPERTHPHSPRKHPE | ||||||
Compositional bias | 637-672 | Polar residues | ||||
Sequence: TAHSGFVSTQISPRPQINPSRRPYGSSLSVDTSPEK | ||||||
Region | 788-807 | Disordered | ||||
Sequence: ASPPGYPYAGPSPSAHHYRN |
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q80XC3-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length819
- Mass (Da)93,574
- Last updated2004-07-30 v2
- ChecksumAD6B72BB42A00B54
Q80XC3-2
- Name2
- Differences from canonical
- 1-2: MN → MIQVLQLVKELVTPSRQKAATAKED
Sequence caution
Features
Showing features for alternative sequence, compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_011153 | 1-2 | in isoform 2 | |||
Sequence: MN → MIQVLQLVKELVTPSRQKAATAKED | ||||||
Compositional bias | 355-369 | Basic and acidic residues | ||||
Sequence: DLPEPGKEDEYPKKP | ||||||
Compositional bias | 378-394 | Polar residues | ||||
Sequence: ACVNHLSNGQRSVGRPS | ||||||
Compositional bias | 395-450 | Basic and acidic residues | ||||
Sequence: PKTSSRREDGSPRKNHEHSPVHHSRNGTPERAGQSRRKSVDEGSKNLKHEAESQRK | ||||||
Sequence conflict | 446 | in Ref. 2; BAE33027 | ||||
Sequence: E → G | ||||||
Compositional bias | 451-477 | Polar residues | ||||
Sequence: PSPGMQDSSRHYNHAAANQNSNAISNV | ||||||
Compositional bias | 561-580 | Basic and acidic residues | ||||
Sequence: ASAEEGPERTHPHSPRKHPE | ||||||
Compositional bias | 637-672 | Polar residues | ||||
Sequence: TAHSGFVSTQISPRPQINPSRRPYGSSLSVDTSPEK | ||||||
Sequence conflict | 765 | in Ref. 2; BAE33027 | ||||
Sequence: A → V |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK129037 EMBL· GenBank· DDBJ | BAC97847.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AK155073 EMBL· GenBank· DDBJ | BAE33027.1 EMBL· GenBank· DDBJ | mRNA | ||
AL845275 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL845515 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC051184 EMBL· GenBank· DDBJ | - | mRNA | No translation available. |