Q80XB4 · NRAP_MOUSE

  • Protein
    Nebulin-related-anchoring protein
  • Gene
    Nrap
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentfascia adherens
Cellular Componentmuscle tendon junction
Cellular Componentmyofibril
Cellular ComponentZ disc
Molecular Functionactin binding
Molecular Functionactin filament binding
Molecular Functionmetal ion binding
Molecular Functionmuscle alpha-actinin binding
Molecular Functionvinculin binding
Biological Processactin cytoskeleton organization
Biological Processcardiac muscle thin filament assembly

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Nebulin-related-anchoring protein
  • Short names
    N-RAP

Gene names

    • Name
      Nrap

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q80XB4
  • Secondary accessions
    • E9QN76
    • O35884
    • Q3UTY7
    • Q3UU10
    • Q80V40

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002488591-1728
Modified residue203Phosphothreonine
Modified residue1078Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in cardiac and skeletal muscle. Not detected in kidney, spleen, liver, brain, lung, stomach or uterus.

Developmental stage

Expression significantly increased from 10.5 dpc to 16.5 dpc, and subsequently remained constant until 21 days after birth. In 9.5 dpc to 10.5 dpc embryonic heart, expression is primarily associated with developing premyofibril structures containing alpha-actinin.

Gene expression databases

Interaction

Subunit

Interacts with actin, alpha-actinin, KLHL41, TLN1 and VCL. Interacts with CSRP3.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, repeat.

TypeIDPosition(s)Description
Domain4-64LIM zinc-binding
Repeat173-200Nebulin 1
Repeat201-235Nebulin 2
Repeat244-271Nebulin 3
Repeat313-340Nebulin 4
Repeat345-379Nebulin 5
Repeat386-414Nebulin 6
Repeat416-450Nebulin 7
Repeat484-518Nebulin 8
Repeat519-553Nebulin 9
Repeat555-589Nebulin 10
Repeat599-623Nebulin 11
Repeat624-658Nebulin 12
Repeat659-689Nebulin 13
Repeat699-721Nebulin 14
Repeat723-757Nebulin 15
Repeat758-792Nebulin 16
Repeat794-828Nebulin 17
Repeat841-866Nebulin 18
Repeat867-893Nebulin 19
Repeat898-932Nebulin 20
Repeat943-960Nebulin 21
Repeat966-1000Nebulin 22
Repeat1001-1035Nebulin 23
Repeat1037-1071Nebulin 24
Repeat1075-1109Nebulin 25
Repeat1110-1136Nebulin 26
Repeat1141-1175Nebulin 27
Repeat1180-1203Nebulin 28
Repeat1209-1243Nebulin 29
Repeat1244-1278Nebulin 30
Repeat1280-1314Nebulin 31
Repeat1318-1352Nebulin 32
Repeat1353-1379Nebulin 33
Repeat1384-1418Nebulin 34
Repeat1425-1446Nebulin 35
Repeat1452-1478Nebulin 36
Repeat1487-1521Nebulin 37
Repeat1523-1557Nebulin 38
Repeat1561-1595Nebulin 39
Repeat1596-1630Nebulin 40
Repeat1637-1661Nebulin 41

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete

This entry describes 4 isoforms produced by Alternative splicing.

Q80XB4-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    S
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    1,728
  • Mass (Da)
    195,756
  • Last updated
    2011-07-27 v3
  • Checksum
    FD21BDD3925FFE4F
MNVQACSRCGYGVYPAEKISCIDQTWHKACFHCEVCKMMLSVNNFVSHQKKPYCHAHNPKNNTFTSVYHTPLNLTLKKSVAAMGGIDGKEDGEPFKSVLHWDMKSKAGAGAASRLMNERDYWPGYAEGNTWCPGALPDPEIVRMVEARQSLGEGYTEDREQQQGKGSFPAMITPAYQRAKAANQLASQVQYKRGHDERVSTFTPVADTPELLRAKAGGQLQNDVRYTEDGGQQRGKGSFPAMITPAYQIAKRATELASDVRYHQQYHREMKGMASPVGAEGGMTKDSVDRCGQVYSEECDEPRGKGSFPAMITPAYQNAKKANELVSDIKYRQDFHKMKGAAHFHSLAAQDNLVLKRAQSVSKLVSEVEYKKGLENSKGHSINYCETPQFRNVSKISKFTSDNKYKENYQTQLRGHYDGVGMDRRMLHALKVGSLASNVAYKADYKHDVVDYNYLATATPFYQTTMRLVPLKDVNYRQNIDRMKFSSVTNTPQIVQAKINAQQLSHVNYRADYERNKLNYTLPQDAPQLLKAKANAELFSEVKYKEGWQKTKGKGFEMKLDAMSLLAAKASGELASSVKYKEEYEKMKGRALGATDSKLLHSLQVAKMSSEVEYKKGFEESKTHFNLPMDMVNLRHAKKAQALASDLDYRKKLHDYTVLPEDMKTQWAKKAYGLQSELQYKADLAWMRGVGWLTEGSLNLEQAKKAGQLISEKNYRQRVDELKFTSVADSSQMEHAKKSQGLQNAVAYKAGNEQSVHQYTISKDEPLFLRARANAAQLSETLYKSSWEKQKAKGFELRLDSLAFLTAKAKRDLASEVKYKEDYERSRGKLIGAKSAQGDSQMSHSLQMSKLQSDLEYKKGFEDTRSQCHISLDMVHLVHARQAQHLATDVGYRTASHCFTALPTDMKVEWAKKAYGLQSDNQYRADMKWMKGTGWVATGSLHVEQAKKAGELISEKKYRQHPDALKFTSIKDTPEMVQARISYTQAVDRLYREQGENVKHHYTQTADLPEVLLAKLNAMNISETRYKESWSRLRDGGYKLRLDALPFQAAKASSEVISDYKYKEAFERMKGQMLGSRSLEDDLSLAHSVHATSLQSDVNYKKGFEHAKAHFHLPLDMVTLVHAKKAQTLASDQDYRHPLPQHTVLAEDLRLSCAKKAHKLQSENLYRSDLNFMRGVPCVVPGTLEIEGRKKASELISESKYRQHPGSFKYTAVTDTPNLLHAKYSNQITNERLYKAAGEDARHQYTMTLGLPEFIRAKTNAANLSEAKYKEAWHNLRAQGYKLTIDALPFQAARASGDIASDFLYRHEFVKERGQLIGVRNVSDDPRLLHCLRMGQLQSENQYRKEAASSQAQCHLPMDMMYLVHARKAQALASDHDYRTQCHEFTALPEDLKMAWAKKAHALQSEFRYKADLMGMKGTGWLALQSPQIESAKKAGDLISETKYRKKPDSIKFTTVVDSPDLIHAKESYMHCNERLYRLGDAASLHRYTPIPDHPDFTRARMNAMHLSDKVYRNAWEQSRAGGYDFRLDAIPFQTARVSRDIASDFRYKEAFLRDRGLQIGYRSISDDPRTTHFLRVGRLQSDNEYRKAFAKGRSQFHSRADQPGFLQAKRSQQLASDVLYRQPLPQHTSDPEQLGLKHARKAHQLQSDVKYKSDLNLTRGVGWTPPGSYKVEMARRAAELANRRGPGIRGASVEPEAAAALGDHQSRGVNPDASEILHIHKKKTLLM

Q80XB4-2

  • Name
    2
  • Synonyms
    C
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q80XB4-3

Q80XB4-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
E9PZF4E9PZF4_MOUSENrap1692
E9Q641E9Q641_MOUSENrap1485
F7CXG1F7CXG1_MOUSENrap387

Sequence caution

The sequence AAC53323.1 differs from that shown. Reason: Frameshift

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0521591-82in isoform 4
Sequence conflict51in Ref. 1; AAC53323
Sequence conflict85in Ref. 2; AAO47075
Sequence conflict109in Ref. 1; AAC53323
Sequence conflict209in Ref. 1; AAC53323
Sequence conflict318in Ref. 1; AAC53323
Alternative sequenceVSP_052160368-402in isoform 2, isoform 3 and isoform 4
Sequence conflict908in Ref. 1; AAC53323
Sequence conflict924in Ref. 2; AAO47076
Sequence conflict956in Ref. 2; AAO47076
Sequence conflict1158in Ref. 2; AAO47075
Sequence conflict1383in Ref. 1; AAC53323
Alternative sequenceVSP_0521621443-1650in isoform 3

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U76618
EMBL· GenBank· DDBJ
AAC53323.1
EMBL· GenBank· DDBJ
mRNA Frameshift
AY177622
EMBL· GenBank· DDBJ
AAO47075.1
EMBL· GenBank· DDBJ
mRNA
AY177623
EMBL· GenBank· DDBJ
AAO47076.1
EMBL· GenBank· DDBJ
mRNA
AC115771
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AK138925
EMBL· GenBank· DDBJ
BAE23819.1
EMBL· GenBank· DDBJ
mRNA
AK138975
EMBL· GenBank· DDBJ
BAE23843.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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