Q80XB4 · NRAP_MOUSE
- ProteinNebulin-related-anchoring protein
- GeneNrap
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1728 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | fascia adherens | |
Cellular Component | muscle tendon junction | |
Cellular Component | myofibril | |
Cellular Component | Z disc | |
Molecular Function | actin binding | |
Molecular Function | actin filament binding | |
Molecular Function | metal ion binding | |
Molecular Function | muscle alpha-actinin binding | |
Molecular Function | vinculin binding | |
Biological Process | actin cytoskeleton organization | |
Biological Process | cardiac muscle thin filament assembly |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameNebulin-related-anchoring protein
- Short namesN-RAP
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ80XB4
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000248859 | 1-1728 | Nebulin-related-anchoring protein | |||
Sequence: MNVQACSRCGYGVYPAEKISCIDQTWHKACFHCEVCKMMLSVNNFVSHQKKPYCHAHNPKNNTFTSVYHTPLNLTLKKSVAAMGGIDGKEDGEPFKSVLHWDMKSKAGAGAASRLMNERDYWPGYAEGNTWCPGALPDPEIVRMVEARQSLGEGYTEDREQQQGKGSFPAMITPAYQRAKAANQLASQVQYKRGHDERVSTFTPVADTPELLRAKAGGQLQNDVRYTEDGGQQRGKGSFPAMITPAYQIAKRATELASDVRYHQQYHREMKGMASPVGAEGGMTKDSVDRCGQVYSEECDEPRGKGSFPAMITPAYQNAKKANELVSDIKYRQDFHKMKGAAHFHSLAAQDNLVLKRAQSVSKLVSEVEYKKGLENSKGHSINYCETPQFRNVSKISKFTSDNKYKENYQTQLRGHYDGVGMDRRMLHALKVGSLASNVAYKADYKHDVVDYNYLATATPFYQTTMRLVPLKDVNYRQNIDRMKFSSVTNTPQIVQAKINAQQLSHVNYRADYERNKLNYTLPQDAPQLLKAKANAELFSEVKYKEGWQKTKGKGFEMKLDAMSLLAAKASGELASSVKYKEEYEKMKGRALGATDSKLLHSLQVAKMSSEVEYKKGFEESKTHFNLPMDMVNLRHAKKAQALASDLDYRKKLHDYTVLPEDMKTQWAKKAYGLQSELQYKADLAWMRGVGWLTEGSLNLEQAKKAGQLISEKNYRQRVDELKFTSVADSSQMEHAKKSQGLQNAVAYKAGNEQSVHQYTISKDEPLFLRARANAAQLSETLYKSSWEKQKAKGFELRLDSLAFLTAKAKRDLASEVKYKEDYERSRGKLIGAKSAQGDSQMSHSLQMSKLQSDLEYKKGFEDTRSQCHISLDMVHLVHARQAQHLATDVGYRTASHCFTALPTDMKVEWAKKAYGLQSDNQYRADMKWMKGTGWVATGSLHVEQAKKAGELISEKKYRQHPDALKFTSIKDTPEMVQARISYTQAVDRLYREQGENVKHHYTQTADLPEVLLAKLNAMNISETRYKESWSRLRDGGYKLRLDALPFQAAKASSEVISDYKYKEAFERMKGQMLGSRSLEDDLSLAHSVHATSLQSDVNYKKGFEHAKAHFHLPLDMVTLVHAKKAQTLASDQDYRHPLPQHTVLAEDLRLSCAKKAHKLQSENLYRSDLNFMRGVPCVVPGTLEIEGRKKASELISESKYRQHPGSFKYTAVTDTPNLLHAKYSNQITNERLYKAAGEDARHQYTMTLGLPEFIRAKTNAANLSEAKYKEAWHNLRAQGYKLTIDALPFQAARASGDIASDFLYRHEFVKERGQLIGVRNVSDDPRLLHCLRMGQLQSENQYRKEAASSQAQCHLPMDMMYLVHARKAQALASDHDYRTQCHEFTALPEDLKMAWAKKAHALQSEFRYKADLMGMKGTGWLALQSPQIESAKKAGDLISETKYRKKPDSIKFTTVVDSPDLIHAKESYMHCNERLYRLGDAASLHRYTPIPDHPDFTRARMNAMHLSDKVYRNAWEQSRAGGYDFRLDAIPFQTARVSRDIASDFRYKEAFLRDRGLQIGYRSISDDPRTTHFLRVGRLQSDNEYRKAFAKGRSQFHSRADQPGFLQAKRSQQLASDVLYRQPLPQHTSDPEQLGLKHARKAHQLQSDVKYKSDLNLTRGVGWTPPGSYKVEMARRAAELANRRGPGIRGASVEPEAAAALGDHQSRGVNPDASEILHIHKKKTLLM | ||||||
Modified residue | 203 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 1078 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in cardiac and skeletal muscle. Not detected in kidney, spleen, liver, brain, lung, stomach or uterus.
Developmental stage
Expression significantly increased from 10.5 dpc to 16.5 dpc, and subsequently remained constant until 21 days after birth. In 9.5 dpc to 10.5 dpc embryonic heart, expression is primarily associated with developing premyofibril structures containing alpha-actinin.
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 4-64 | LIM zinc-binding | ||||
Sequence: QACSRCGYGVYPAEKISCIDQTWHKACFHCEVCKMMLSVNNFVSHQKKPYCHAHNPKNNTF | ||||||
Repeat | 173-200 | Nebulin 1 | ||||
Sequence: TPAYQRAKAANQLASQVQYKRGHDERVS | ||||||
Repeat | 201-235 | Nebulin 2 | ||||
Sequence: TFTPVADTPELLRAKAGGQLQNDVRYTEDGGQQRG | ||||||
Repeat | 244-271 | Nebulin 3 | ||||
Sequence: TPAYQIAKRATELASDVRYHQQYHREMK | ||||||
Repeat | 313-340 | Nebulin 4 | ||||
Sequence: TPAYQNAKKANELVSDIKYRQDFHKMKG | ||||||
Repeat | 345-379 | Nebulin 5 | ||||
Sequence: HSLAAQDNLVLKRAQSVSKLVSEVEYKKGLENSKG | ||||||
Repeat | 386-414 | Nebulin 6 | ||||
Sequence: ETPQFRNVSKISKFTSDNKYKENYQTQLR | ||||||
Repeat | 416-450 | Nebulin 7 | ||||
Sequence: HYDGVGMDRRMLHALKVGSLASNVAYKADYKHDVV | ||||||
Repeat | 484-518 | Nebulin 8 | ||||
Sequence: KFSSVTNTPQIVQAKINAQQLSHVNYRADYERNKL | ||||||
Repeat | 519-553 | Nebulin 9 | ||||
Sequence: NYTLPQDAPQLLKAKANAELFSEVKYKEGWQKTKG | ||||||
Repeat | 555-589 | Nebulin 10 | ||||
Sequence: GFEMKLDAMSLLAAKASGELASSVKYKEEYEKMKG | ||||||
Repeat | 599-623 | Nebulin 11 | ||||
Sequence: LLHSLQVAKMSSEVEYKKGFEESKT | ||||||
Repeat | 624-658 | Nebulin 12 | ||||
Sequence: HFNLPMDMVNLRHAKKAQALASDLDYRKKLHDYTV | ||||||
Repeat | 659-689 | Nebulin 13 | ||||
Sequence: LPEDMKTQWAKKAYGLQSELQYKADLAWMRG | ||||||
Repeat | 699-721 | Nebulin 14 | ||||
Sequence: NLEQAKKAGQLISEKNYRQRVDE | ||||||
Repeat | 723-757 | Nebulin 15 | ||||
Sequence: KFTSVADSSQMEHAKKSQGLQNAVAYKAGNEQSVH | ||||||
Repeat | 758-792 | Nebulin 16 | ||||
Sequence: QYTISKDEPLFLRARANAAQLSETLYKSSWEKQKA | ||||||
Repeat | 794-828 | Nebulin 17 | ||||
Sequence: GFELRLDSLAFLTAKAKRDLASEVKYKEDYERSRG | ||||||
Repeat | 841-866 | Nebulin 18 | ||||
Sequence: QMSHSLQMSKLQSDLEYKKGFEDTRS | ||||||
Repeat | 867-893 | Nebulin 19 | ||||
Sequence: QCHISLDMVHLVHARQAQHLATDVGYR | ||||||
Repeat | 898-932 | Nebulin 20 | ||||
Sequence: CFTALPTDMKVEWAKKAYGLQSDNQYRADMKWMKG | ||||||
Repeat | 943-960 | Nebulin 21 | ||||
Sequence: VEQAKKAGELISEKKYRQ | ||||||
Repeat | 966-1000 | Nebulin 22 | ||||
Sequence: KFTSIKDTPEMVQARISYTQAVDRLYREQGENVKH | ||||||
Repeat | 1001-1035 | Nebulin 23 | ||||
Sequence: HYTQTADLPEVLLAKLNAMNISETRYKESWSRLRD | ||||||
Repeat | 1037-1071 | Nebulin 24 | ||||
Sequence: GYKLRLDALPFQAAKASSEVISDYKYKEAFERMKG | ||||||
Repeat | 1075-1109 | Nebulin 25 | ||||
Sequence: GSRSLEDDLSLAHSVHATSLQSDVNYKKGFEHAKA | ||||||
Repeat | 1110-1136 | Nebulin 26 | ||||
Sequence: HFHLPLDMVTLVHAKKAQTLASDQDYR | ||||||
Repeat | 1141-1175 | Nebulin 27 | ||||
Sequence: QHTVLAEDLRLSCAKKAHKLQSENLYRSDLNFMRG | ||||||
Repeat | 1180-1203 | Nebulin 28 | ||||
Sequence: VPGTLEIEGRKKASELISESKYRQ | ||||||
Repeat | 1209-1243 | Nebulin 29 | ||||
Sequence: KYTAVTDTPNLLHAKYSNQITNERLYKAAGEDARH | ||||||
Repeat | 1244-1278 | Nebulin 30 | ||||
Sequence: QYTMTLGLPEFIRAKTNAANLSEAKYKEAWHNLRA | ||||||
Repeat | 1280-1314 | Nebulin 31 | ||||
Sequence: GYKLTIDALPFQAARASGDIASDFLYRHEFVKERG | ||||||
Repeat | 1318-1352 | Nebulin 32 | ||||
Sequence: GVRNVSDDPRLLHCLRMGQLQSENQYRKEAASSQA | ||||||
Repeat | 1353-1379 | Nebulin 33 | ||||
Sequence: QCHLPMDMMYLVHARKAQALASDHDYR | ||||||
Repeat | 1384-1418 | Nebulin 34 | ||||
Sequence: EFTALPEDLKMAWAKKAHALQSEFRYKADLMGMKG | ||||||
Repeat | 1425-1446 | Nebulin 35 | ||||
Sequence: QSPQIESAKKAGDLISETKYRK | ||||||
Repeat | 1452-1478 | Nebulin 36 | ||||
Sequence: KFTTVVDSPDLIHAKESYMHCNERLYR | ||||||
Repeat | 1487-1521 | Nebulin 37 | ||||
Sequence: RYTPIPDHPDFTRARMNAMHLSDKVYRNAWEQSRA | ||||||
Repeat | 1523-1557 | Nebulin 38 | ||||
Sequence: GYDFRLDAIPFQTARVSRDIASDFRYKEAFLRDRG | ||||||
Repeat | 1561-1595 | Nebulin 39 | ||||
Sequence: GYRSISDDPRTTHFLRVGRLQSDNEYRKAFAKGRS | ||||||
Repeat | 1596-1630 | Nebulin 40 | ||||
Sequence: QFHSRADQPGFLQAKRSQQLASDVLYRQPLPQHTS | ||||||
Repeat | 1637-1661 | Nebulin 41 | ||||
Sequence: LKHARKAHQLQSDVKYKSDLNLTRG |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 4 isoforms produced by Alternative splicing.
Q80XB4-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsS
- Length1,728
- Mass (Da)195,756
- Last updated2011-07-27 v3
- ChecksumFD21BDD3925FFE4F
Q80XB4-2
- Name2
- SynonymsC
- Differences from canonical
- 368-402: Missing
Q80XB4-3
- Name3
- Differences from canonical
- 368-402: Missing
- 1443-1650: Missing
Q80XB4-4
- Name4
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Sequence caution
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_052159 | 1-82 | in isoform 4 | |||
Sequence: Missing | ||||||
Sequence conflict | 51 | in Ref. 1; AAC53323 | ||||
Sequence: K → M | ||||||
Sequence conflict | 85 | in Ref. 2; AAO47075 | ||||
Sequence: G → R | ||||||
Sequence conflict | 109 | in Ref. 1; AAC53323 | ||||
Sequence: A → T | ||||||
Sequence conflict | 209 | in Ref. 1; AAC53323 | ||||
Sequence: P → A | ||||||
Sequence conflict | 318 | in Ref. 1; AAC53323 | ||||
Sequence: N → T | ||||||
Alternative sequence | VSP_052160 | 368-402 | in isoform 2, isoform 3 and isoform 4 | |||
Sequence: Missing | ||||||
Sequence conflict | 908 | in Ref. 1; AAC53323 | ||||
Sequence: V → A | ||||||
Sequence conflict | 924 | in Ref. 2; AAO47076 | ||||
Sequence: R → G | ||||||
Sequence conflict | 956 | in Ref. 2; AAO47076 | ||||
Sequence: K → E | ||||||
Sequence conflict | 1158 | in Ref. 2; AAO47075 | ||||
Sequence: H → R | ||||||
Sequence conflict | 1383 | in Ref. 1; AAC53323 | ||||
Sequence: H → R | ||||||
Alternative sequence | VSP_052162 | 1443-1650 | in isoform 3 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U76618 EMBL· GenBank· DDBJ | AAC53323.1 EMBL· GenBank· DDBJ | mRNA | Frameshift | |
AY177622 EMBL· GenBank· DDBJ | AAO47075.1 EMBL· GenBank· DDBJ | mRNA | ||
AY177623 EMBL· GenBank· DDBJ | AAO47076.1 EMBL· GenBank· DDBJ | mRNA | ||
AC115771 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AK138925 EMBL· GenBank· DDBJ | BAE23819.1 EMBL· GenBank· DDBJ | mRNA | ||
AK138975 EMBL· GenBank· DDBJ | BAE23843.1 EMBL· GenBank· DDBJ | mRNA |