Q80W88 · HOMEZ_MOUSE

  • Protein
    Homeobox and leucine zipper protein Homez
  • Gene
    Homez
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May function as a transcriptional regulator.

Caution

It is uncertain whether Met-1 or Met-25 is the initiator.

Features

Showing features for dna binding.

154250100150200250300350400450500
TypeIDPosition(s)Description
DNA binding55-114Homeobox 1
DNA binding349-409Homeobox 2
DNA binding443-502Homeobox 3

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Biological Processregulation of transcription by RNA polymerase II

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Homeobox and leucine zipper protein Homez
  • Alternative names
    • Homeodomain leucine zipper-containing factor

Gene names

    • Name
      Homez
    • Synonyms
      Kiaa1443

Organism names

  • Taxonomic identifier
  • Strains
    • Swiss Webster / NIH
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q80W88
  • Secondary accessions
    • Q504Z8

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, cross-link, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000491361-542Homeobox and leucine zipper protein Homez
Cross-link181Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Cross-link201Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Modified residue345Phosphoserine
Modified residue443Phosphothreonine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Ubiquitous. Strongly expressed in testis.

Developmental stage

First expressed at 7 dpc. At 8.5-9 dpc expressed in all developing organs. Later on during embryogenesis shows a more restricted expression pattern. At 9.5-12.5 dpc it is strongly expressed in the developing brain, optic vesicle and the otic placode.

Interaction

Subunit

Homodimer or heterodimer (Potential). Interacts with HOXC8 (By similarity).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
XENO Q80W88GTF2IRD1 Q9UHL92EBI-12516872, EBI-372530

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias, motif.

TypeIDPosition(s)Description
Region165-193Disordered
Region250-307Disordered
Compositional bias263-307Polar residues
Motif352-357Nuclear localization signal
Region424-454Disordered
Region501-542Disordered
Compositional bias504-542Acidic residues

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q80W88-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    542
  • Mass (Da)
    60,914
  • Last updated
    2011-01-11 v2
  • Checksum
    244C833F148A9B62
MLGHRLLPSLDFPAVSEGYKPEHDMSPNKDASSLNSSAAGLVCLPPVSEELQLVWTQAIQTSELDGNEHLLQAFSYFPYPSLADIALLCLRHGLQMEKVKTWFMAQRLRCGISWSSEEIEETRARVVYHRDQLLFKSLLSFTQQSVRPPQERPPVLRPEQVALGLSPLAPSEQPTHMKGLKVEPEEPSQVSQLPLNHQNAKEPLMMGSRTFSHQSDCQDLQISGLSKEQAGRGPDQSCGKTASWNHFTAVHQPDKPASVSLLDNSCKEESEPSGIPPSSSTSSPSFQALANGTTATPKPLQPLGCISQSLSPSKKALSPQVEPLWPQRLWNNSEPNSAGPTEYLSPDMQHQRKTKRKTKEQLAILKSFFLQCQWARREDYHKLEQITGLPRPEIIQWFGDTRYALKHGQLKWFRDNAVLGTPSFQDPAIPTPSTRSLKEWAKTPPLPAPPPPPDIRPLEKYWAAHQQLQEADILKLSQASRLSTQQVLDWFDSRLPKPAEVVVCLDEEDEEDEEDELPEDGEEEEEEEEDDDDGDDDVIIWD

Q80W88-2

  • Name
    2
  • Note
    May result from the retention of an intron.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 522-542: EEEEEEEEDDDDGDDDVIIWD → SVWTEGPWSSNSMMF

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0R4J108A0A0R4J108_MOUSEHomez518
D3YV74D3YV74_MOUSEHomez114
H3BL46H3BL46_MOUSEHomez162

Sequence caution

The sequence AAH94669.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence BAC98171.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Features

Showing features for compositional bias, sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Compositional bias263-307Polar residues
Sequence conflict297in Ref. 2; BAC98171
Sequence conflict314in Ref. 2; BAC98171
Sequence conflict389in Ref. 1; AAP32905
Compositional bias504-542Acidic residues
Alternative sequenceVSP_009133522-542in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY258064
EMBL· GenBank· DDBJ
AAP32905.1
EMBL· GenBank· DDBJ
mRNA
AK129361
EMBL· GenBank· DDBJ
BAC98171.1
EMBL· GenBank· DDBJ
mRNA Different initiation
BC094669
EMBL· GenBank· DDBJ
AAH94669.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp