Q80W88 · HOMEZ_MOUSE
- ProteinHomeobox and leucine zipper protein Homez
- GeneHomez
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids542 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May function as a transcriptional regulator.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 55-114 | Homeobox 1 | ||||
Sequence: WTQAIQTSELDGNEHLLQAFSYFPYPSLADIALLCLRHGLQMEKVKTWFMAQRLRCGISW | ||||||
DNA binding | 349-409 | Homeobox 2 | ||||
Sequence: QHQRKTKRKTKEQLAILKSFFLQCQWARREDYHKLEQITGLPRPEIIQWFGDTRYALKHGQ | ||||||
DNA binding | 443-502 | Homeobox 3 | ||||
Sequence: TPPLPAPPPPPDIRPLEKYWAAHQQLQEADILKLSQASRLSTQQVLDWFDSRLPKPAEVV |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Biological Process | regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameHomeobox and leucine zipper protein Homez
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ80W88
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, cross-link, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000049136 | 1-542 | Homeobox and leucine zipper protein Homez | |||
Sequence: MLGHRLLPSLDFPAVSEGYKPEHDMSPNKDASSLNSSAAGLVCLPPVSEELQLVWTQAIQTSELDGNEHLLQAFSYFPYPSLADIALLCLRHGLQMEKVKTWFMAQRLRCGISWSSEEIEETRARVVYHRDQLLFKSLLSFTQQSVRPPQERPPVLRPEQVALGLSPLAPSEQPTHMKGLKVEPEEPSQVSQLPLNHQNAKEPLMMGSRTFSHQSDCQDLQISGLSKEQAGRGPDQSCGKTASWNHFTAVHQPDKPASVSLLDNSCKEESEPSGIPPSSSTSSPSFQALANGTTATPKPLQPLGCISQSLSPSKKALSPQVEPLWPQRLWNNSEPNSAGPTEYLSPDMQHQRKTKRKTKEQLAILKSFFLQCQWARREDYHKLEQITGLPRPEIIQWFGDTRYALKHGQLKWFRDNAVLGTPSFQDPAIPTPSTRSLKEWAKTPPLPAPPPPPDIRPLEKYWAAHQQLQEADILKLSQASRLSTQQVLDWFDSRLPKPAEVVVCLDEEDEEDEEDELPEDGEEEEEEEEDDDDGDDDVIIWD | ||||||
Cross-link | 181 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Cross-link | 201 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Modified residue | 345 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 443 | Phosphothreonine | ||||
Sequence: T |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Ubiquitous. Strongly expressed in testis.
Developmental stage
First expressed at 7 dpc. At 8.5-9 dpc expressed in all developing organs. Later on during embryogenesis shows a more restricted expression pattern. At 9.5-12.5 dpc it is strongly expressed in the developing brain, optic vesicle and the otic placode.
Interaction
Subunit
Homodimer or heterodimer (Potential). Interacts with HOXC8 (By similarity).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
XENO | Q80W88 | GTF2IRD1 Q9UHL9 | 2 | EBI-12516872, EBI-372530 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 165-193 | Disordered | ||||
Sequence: LSPLAPSEQPTHMKGLKVEPEEPSQVSQL | ||||||
Region | 250-307 | Disordered | ||||
Sequence: VHQPDKPASVSLLDNSCKEESEPSGIPPSSSTSSPSFQALANGTTATPKPLQPLGCIS | ||||||
Compositional bias | 263-307 | Polar residues | ||||
Sequence: DNSCKEESEPSGIPPSSSTSSPSFQALANGTTATPKPLQPLGCIS | ||||||
Motif | 352-357 | Nuclear localization signal | ||||
Sequence: RKTKRK | ||||||
Region | 424-454 | Disordered | ||||
Sequence: FQDPAIPTPSTRSLKEWAKTPPLPAPPPPPD | ||||||
Region | 501-542 | Disordered | ||||
Sequence: VVVCLDEEDEEDEEDELPEDGEEEEEEEEDDDDGDDDVIIWD | ||||||
Compositional bias | 504-542 | Acidic residues | ||||
Sequence: CLDEEDEEDEEDELPEDGEEEEEEEEDDDDGDDDVIIWD |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q80W88-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length542
- Mass (Da)60,914
- Last updated2011-01-11 v2
- Checksum244C833F148A9B62
Q80W88-2
- Name2
- NoteMay result from the retention of an intron.
- Differences from canonical
- 522-542: EEEEEEEEDDDDGDDDVIIWD → SVWTEGPWSSNSMMF
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0R4J108 | A0A0R4J108_MOUSE | Homez | 518 | ||
D3YV74 | D3YV74_MOUSE | Homez | 114 | ||
H3BL46 | H3BL46_MOUSE | Homez | 162 |
Sequence caution
Features
Showing features for compositional bias, sequence conflict, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 263-307 | Polar residues | ||||
Sequence: DNSCKEESEPSGIPPSSSTSSPSFQALANGTTATPKPLQPLGCIS | ||||||
Sequence conflict | 297 | in Ref. 2; BAC98171 | ||||
Sequence: P → L | ||||||
Sequence conflict | 314 | in Ref. 2; BAC98171 | ||||
Sequence: K → E | ||||||
Sequence conflict | 389 | in Ref. 1; AAP32905 | ||||
Sequence: L → S | ||||||
Compositional bias | 504-542 | Acidic residues | ||||
Sequence: CLDEEDEEDEEDELPEDGEEEEEEEEDDDDGDDDVIIWD | ||||||
Alternative sequence | VSP_009133 | 522-542 | in isoform 2 | |||
Sequence: EEEEEEEEDDDDGDDDVIIWD → SVWTEGPWSSNSMMF |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY258064 EMBL· GenBank· DDBJ | AAP32905.1 EMBL· GenBank· DDBJ | mRNA | ||
AK129361 EMBL· GenBank· DDBJ | BAC98171.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
BC094669 EMBL· GenBank· DDBJ | AAH94669.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |