Q80W80 · Q80W80_MOUSE
- ProteinStress-activated protein kinase JNK
- GeneMapk10
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids464 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | JUN kinase activity | |
Molecular Function | protein serine kinase activity | |
Biological Process | phosphate-containing compound metabolic process | |
Biological Process | rhythmic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameStress-activated protein kinase JNK
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ80W80
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 64-359 | Protein kinase | ||||
Sequence: YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVKGTVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI | ||||||
Region | 405-464 | Disordered | ||||
Sequence: TKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR | ||||||
Compositional bias | 406-454 | Polar residues | ||||
Sequence: KNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLE |
Sequence similarities
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length464
- Mass (Da)52,288
- Last updated2003-06-01 v1
- Checksum8737935918876470
Computationally mapped potential isoform sequences
There are 9 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q61831 | MK10_MOUSE | Mapk10 | 464 | ||
Q3TQZ7 | Q3TQZ7_MOUSE | Mapk10 | 418 | ||
Q80W82 | Q80W82_MOUSE | Mapk10 | 422 | ||
A0A5F8MP75 | A0A5F8MP75_MOUSE | Mapk10 | 478 | ||
Q8C9D4 | Q8C9D4_MOUSE | Mapk10 | 464 | ||
E9QN59 | E9QN59_MOUSE | Mapk10 | 494 | ||
A0A0G2JG69 | A0A0G2JG69_MOUSE | Mapk10 | 178 | ||
A0A0G2JGL2 | A0A0G2JGL2_MOUSE | Mapk10 | 252 | ||
A0A0G2JEJ8 | A0A0G2JEJ8_MOUSE | Mapk10 | 173 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 406-454 | Polar residues | ||||
Sequence: KNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLE |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB096079 EMBL· GenBank· DDBJ | BAC76453.1 EMBL· GenBank· DDBJ | mRNA |