Q80V72 · IP6K2_MOUSE
- ProteinInositol hexakisphosphate kinase 2
- GeneIp6k2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids448 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5) (By similarity).
May play a role in the regulation of Na+-dependent phosphate cotransport, possibly via its role in diphosphoinositol pentakisphosphate (InsP7/PP-InsP5) biosynthesis (By similarity).
May play a role in the regulation of Na+-dependent phosphate cotransport, possibly via its role in diphosphoinositol pentakisphosphate (InsP7/PP-InsP5) biosynthesis (By similarity).
Catalytic activity
- 1D-myo-inositol hexakisphosphate + ATP = 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP
Pathway
Phospholipid metabolism; phosphatidylinositol metabolism.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 229-231 | ATP (UniProtKB | ChEBI) | ||||
Sequence: ENL | ||||||
Binding site | 238-246 | substrate | ||||
Sequence: PCVLDLKMG | ||||||
Binding site | 242 | ATP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 244 | substrate | ||||
Sequence: K | ||||||
Binding site | 258-265 | substrate | ||||
Sequence: KAANQIRK | ||||||
Binding site | 405 | ATP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 408 | substrate | ||||
Sequence: H |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell junction | |
Cellular Component | cytoplasm | |
Cellular Component | fibrillar center | |
Cellular Component | nucleoplasm | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | flavonoid binding | |
Molecular Function | inositol hexakisphosphate 5-kinase activity | |
Molecular Function | inositol hexakisphosphate kinase activity | |
Molecular Function | protein-containing complex binding | |
Biological Process | cellular response to flavonoid | |
Biological Process | inositol phosphate biosynthetic process | |
Biological Process | inositol phosphate metabolic process | |
Biological Process | negative regulation of cell growth | |
Biological Process | phosphate ion transport | |
Biological Process | phosphatidylinositol phosphate biosynthetic process | |
Biological Process | positive regulation of apoptotic process | |
Biological Process | positive regulation of peptidyl-serine phosphorylation | |
Biological Process | protein stabilization |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameInositol hexakisphosphate kinase 2
- EC number
- Short namesInsP6 kinase 2
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ80V72
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 17 variants from UniProt as well as other sources including ClinVar and dbSNP.
Chemistry
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000066878 | 1-448 | Inositol hexakisphosphate kinase 2 | |||
Sequence: MSPAFRTMDVEPRTKGILLEPFVHQVGGHSCVLRFNETTLCKPLVPREHQFYETLPAEMRRFTPQYKAVLIFVRCADEFGASGNIETKEQGVVSVRFEEDEDRNLCLIAYPLKGDHGTVDIVDNSDCEPKSKLLRWTNKKHHALETEKNPKDWVRQHRKEEKMKSHKLEEEFEWLKKSEVLYYSVEKKGNVSSQLKHYNPWSMKCHQQQLQRMKENAKHRNQYKFILLENLTSRYEVPCVLDLKMGTRQHGDDASEEKAANQIRKCQQSTSAVIGVRVCGMQVYQAGTGQLMFMNKYHGRKLSVQGFKEALFQFFHNGRYLRRELLGPVLKKLTELKAVLERQESYRFYSSSLLVIYDGKEWPEVTLDSDAEDLEDLSEESADESAGAYAYKPIGASSVDVRMIDFAHTTCRLYGEDSVVHEGQDAGYIFGLQSLIDIVTEISEESGE |
Proteomic databases
PTM databases
Expression
Tissue specificity
Highly expressed in brain and lung, and at slightly lower levels in liver, kidney and testis.
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length448
- Mass (Da)51,644
- Last updated2011-07-27 v2
- ChecksumA1B483785C5DAE25
Computationally mapped potential isoform sequences
There are 8 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0A6YVS3 | A0A0A6YVS3_MOUSE | Ip6k2 | 73 | ||
A0A0A6YWE4 | A0A0A6YWE4_MOUSE | Ip6k2 | 31 | ||
A0A0A6YWA1 | A0A0A6YWA1_MOUSE | Ip6k2 | 86 | ||
A0A0A6YWM3 | A0A0A6YWM3_MOUSE | Ip6k2 | 402 | ||
A0A0A6YX46 | A0A0A6YX46_MOUSE | Ip6k2 | 151 | ||
Q6PAT6 | Q6PAT6_MOUSE | Ip6k2 | 123 | ||
A0A0A6YY18 | A0A0A6YY18_MOUSE | Ip6k2 | 110 | ||
A0A0A6YXT7 | A0A0A6YXT7_MOUSE | Ip6k2 | 98 |
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 292 | in Ref. 2; AAH39922 | ||||
Sequence: M → I |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC168054 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC173341 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC039922 EMBL· GenBank· DDBJ | AAH39922.1 EMBL· GenBank· DDBJ | mRNA |