Q80V72 · IP6K2_MOUSE

  • Protein
    Inositol hexakisphosphate kinase 2
  • Gene
    Ip6k2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5) (By similarity).
May play a role in the regulation of Na+-dependent phosphate cotransport, possibly via its role in diphosphoinositol pentakisphosphate (InsP7/PP-InsP5) biosynthesis (By similarity).

Catalytic activity

Pathway

Phospholipid metabolism; phosphatidylinositol metabolism.

Features

Showing features for binding site.

144850100150200250300350400
TypeIDPosition(s)Description
Binding site229-231ATP (UniProtKB | ChEBI)
Binding site238-246substrate
Binding site242ATP (UniProtKB | ChEBI)
Binding site244substrate
Binding site258-265substrate
Binding site405ATP (UniProtKB | ChEBI)
Binding site408substrate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell junction
Cellular Componentcytoplasm
Cellular Componentfibrillar center
Cellular Componentnucleoplasm
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular Functionflavonoid binding
Molecular Functioninositol hexakisphosphate 5-kinase activity
Molecular Functioninositol hexakisphosphate kinase activity
Molecular Functionprotein-containing complex binding
Biological Processcellular response to flavonoid
Biological Processinositol phosphate biosynthetic process
Biological Processinositol phosphate metabolic process
Biological Processnegative regulation of cell growth
Biological Processphosphate ion transport
Biological Processphosphatidylinositol phosphate biosynthetic process
Biological Processpositive regulation of apoptotic process
Biological Processpositive regulation of peptidyl-serine phosphorylation
Biological Processprotein stabilization

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inositol hexakisphosphate kinase 2
  • EC number
  • Short names
    InsP6 kinase 2
  • Alternative names
    • P(i)-uptake stimulator (PiUS)

Gene names

    • Name
      Ip6k2
    • Synonyms
      Ihpk2

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q80V72
  • Secondary accessions
    • E9QMT6

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 17 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Chemistry

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000668781-448Inositol hexakisphosphate kinase 2

Proteomic databases

PTM databases

Expression

Tissue specificity

Highly expressed in brain and lung, and at slightly lower levels in liver, kidney and testis.

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    448
  • Mass (Da)
    51,644
  • Last updated
    2011-07-27 v2
  • Checksum
    A1B483785C5DAE25
MSPAFRTMDVEPRTKGILLEPFVHQVGGHSCVLRFNETTLCKPLVPREHQFYETLPAEMRRFTPQYKAVLIFVRCADEFGASGNIETKEQGVVSVRFEEDEDRNLCLIAYPLKGDHGTVDIVDNSDCEPKSKLLRWTNKKHHALETEKNPKDWVRQHRKEEKMKSHKLEEEFEWLKKSEVLYYSVEKKGNVSSQLKHYNPWSMKCHQQQLQRMKENAKHRNQYKFILLENLTSRYEVPCVLDLKMGTRQHGDDASEEKAANQIRKCQQSTSAVIGVRVCGMQVYQAGTGQLMFMNKYHGRKLSVQGFKEALFQFFHNGRYLRRELLGPVLKKLTELKAVLERQESYRFYSSSLLVIYDGKEWPEVTLDSDAEDLEDLSEESADESAGAYAYKPIGASSVDVRMIDFAHTTCRLYGEDSVVHEGQDAGYIFGLQSLIDIVTEISEESGE

Computationally mapped potential isoform sequences

There are 8 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0A6YVS3A0A0A6YVS3_MOUSEIp6k273
A0A0A6YWE4A0A0A6YWE4_MOUSEIp6k231
A0A0A6YWA1A0A0A6YWA1_MOUSEIp6k286
A0A0A6YWM3A0A0A6YWM3_MOUSEIp6k2402
A0A0A6YX46A0A0A6YX46_MOUSEIp6k2151
Q6PAT6Q6PAT6_MOUSEIp6k2123
A0A0A6YY18A0A0A6YY18_MOUSEIp6k2110
A0A0A6YXT7A0A0A6YXT7_MOUSEIp6k298

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict292in Ref. 2; AAH39922

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC168054
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC173341
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC039922
EMBL· GenBank· DDBJ
AAH39922.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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