Q80U93 · NU214_MOUSE
- ProteinNuclear pore complex protein Nup214
- GeneNup214
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids2085 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Part of the nuclear pore complex. Has a critical role in nucleocytoplasmic transport. May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasmic side of nuclear pore | |
Cellular Component | nuclear envelope | |
Cellular Component | nuclear pore | |
Molecular Function | nuclear export signal receptor activity | |
Molecular Function | nuclear localization sequence binding | |
Molecular Function | structural constituent of nuclear pore | |
Biological Process | mRNA export from nucleus | |
Biological Process | nucleocytoplasmic transport | |
Biological Process | protein export from nucleus | |
Biological Process | protein import into nucleus | |
Biological Process | regulation of cell cycle | |
Biological Process | regulation of nucleocytoplasmic transport | |
Biological Process | RNA export from nucleus |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNuclear pore complex protein Nup214
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ80U93
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Cytoplasmic side of the nuclear pore complex.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain, cross-link.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Modified residue | 2 | N-acetylglycine | ||||
Sequence: G | ||||||
Chain | PRO_0000345014 | 2-2085 | Nuclear pore complex protein Nup214 | |||
Sequence: GDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSVLTISNKYGMLFAGGTNGLNVFPTKSLLIQNKPGDDPNKIVDTIQGLNVPMKFPVHHLALSCDSLTLSACMMSSEYGSIIAFFDVRTFSNQAKPLKRPFTYHKVSNDASGMVNDMKWNPTVPSMVAVCLADGSISVLQVTDVVKVCATLPPSTGVTCVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPPFYESDHPVRVLDVLWIGTYVFTIVYAGADGTLETCPDVVMALLPKKEEKHPEIFVNFMEPCYSSCTERQHHYYLSYIEEWDLVLAASAASTEVSILARQNDQTNWESWLLEDSSRAELPVTDKSDDSLPMGVAIDYTNEVEVTINEEKTLPPAPVLLLLSTDGVLCPFYMINQNPGVRSLIKTLELISTEGERQPKSSGSFPGTPSSPQAPQNLDAPATASSPLPPVSAAPTSTFPMPSAAGSPSVFSFGPSSFKSSASVTGEPPLYPTGSDSSRAAPGSGTSTFSFAPPSKGSLASTPAVAPVATSAAPFTFGFKPTLESTPMSSTPNTGMKPSFPPSASSVKVNLNEKFTAVASSAPVHSSTSTPSVLPFSSSPKPTASGPLSHPTPLPASSSSMPLKSSVSPSPAAGRSTQTAPSSAPSTGQKSPRVNPPVPKSGSSQAKALQPPVTEKQRPQWKDSDPVLAGIGEEIAHFQKELEELKARTAKACLQVGTSEEMKMLRTESDDLHTFLFEIRETTESLHGDISTLKTTLLEGFAGVEEAREQHGRNHDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDRHLEQKKRQRRLIVPERETLFNTLANNREIINQQRKRLNQLVDSLQQLRLYNHTAPWSLPSALSTQSNSHSFDSDLECLLKTTIESHTKPSPRVPGKLSPAKQAQLRNFLAKRKTPPVRSTAPASLSRSAFLSQRYYEDLDEGSSASSVAQPLEGEDARPTCTSVAQPLEGEDAQPICKEEEAVVPVPRHAPVVRTPSIQPSLLPQSMPFAKPHLIHSSSPAVMSSAVSTSATKVIPQGADSTMLATKTVKHGAPGPSHTVAAPQAAAAAALRRQMASQAPAMSTLTESTLKTVPQVVNVQELRSNPSPPSAAMGSAVQHSAAKTPHAVLTPVANSQAKQGSLINSFKPSGPTAASCQLSSGDKAVGQGTAKTESAATSTPSAAGQLNKPFSFASPGTFTFGTITPTPSSSFTATPGAGPPTKEPTQLEAFSFGGGGKPFSEAIPGNSPATGATSAPSTSVTAASLEDSAPSSSKPAAPPETTVSSASSKLETPPSKLGELLFPSSLAGETLGSFSGLRVGQAEDSTKPVSKASSTNLAGAQPAKPSGVSFPNTSVLGKPVEPAVTSSVSPAPAAPASALNVSTSSSSATVFGSVPLTSAGPPGLISFGGAALASSKASFSFGNQQTSSSTASSATPTSTSVAPSLPASFPTLSFGGLLSSPSASSLPVSSGKSTEEAAPPAVPDKSDSSEVSATTPSLPVQPQSTQASLQTSDPVKKEPVLVQTTDSSPSRPASSASFVASTESMPVTLGAPDSKIEAVSPASTFAGPGQAAVATAVLPGAGSAATEASGTPTTSTVSSSSPTSATETAVFGTATSGSSVFTQPPAASSSSAFSQLSSNTATAPSATPVFGQVAASITSTAAATPQASSSGFGSPAFGASAPGVFGQTAFGQTPAFGQATSSPASGFSFSQPGFSSVPAFGQSVSSTPASTSANVFGATSSTSSPGSFSFGQASTNTGGTLFGQNNPPAFGQSPGFGQGSSVFGGTSATTSTAAPSGFSFCQASGFGSSNTGSVFGQAANTGGSVFGQSSTSSGGVFGSGNATRGGGFFSGLGGKPSQDAANKNPFSSAGGGFGSTAAPNTSNLFGNSGAKTFGGFGSSSFGEQKPAGTFSSGGGSVASQGFGFSTPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSGNTASFGTLASQNAPTFGSLSQQTSGFGTPSSGFAGFGSGTGAFTFGSSNSSVQGFGGWRS | ||||||
Modified residue | 30 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 416 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 421 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 430 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 433 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 437 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 645 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 651 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 660 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 672 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 754 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 930 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 960 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 964 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 979 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1027 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 1029 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1051 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1062 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1139 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1156 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 1162 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 1187 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1324 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 1365 | Phosphoserine | ||||
Sequence: S | ||||||
Cross-link | 1548 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Modified residue | 1980 | Phosphoserine | ||||
Sequence: S |
Post-translational modification
Probably glycosylated as it reacts with wheat germ agglutinin (WGA).
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Homodimer. Part of the nuclear pore complex (NPC). Interacts with NUP88. Interacts with ZFP36; this interaction increases upon lipopolysaccharide (LPS) stimulation. Interacts with DDX19. Interacts with XPO1. Interacts with XPO5.
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for repeat, region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 41-93 | Blade 1 | ||||
Sequence: VLTISNKYGMLFAGGTNGLNVFPTKSLLIQNKPGDDPNKIVDTIQGLNVPMKF | ||||||
Region | 41-404 | Seven-bladed beta propeller | ||||
Sequence: VLTISNKYGMLFAGGTNGLNVFPTKSLLIQNKPGDDPNKIVDTIQGLNVPMKFPVHHLALSCDSLTLSACMMSSEYGSIIAFFDVRTFSNQAKPLKRPFTYHKVSNDASGMVNDMKWNPTVPSMVAVCLADGSISVLQVTDVVKVCATLPPSTGVTCVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPPFYESDHPVRVLDVLWIGTYVFTIVYAGADGTLETCPDVVMALLPKKEEKHPEIFVNFMEPCYSSCTERQHHYYLSYIEEWDLVLAASAASTEVSILARQNDQTNWESWLLEDSSRAELPVTDKSDDSLPMGVAIDYTNEVEVTINEEKTLPPAPVLLLLSTDGVLCPFYMI | ||||||
Repeat | 94-150 | Blade 2 | ||||
Sequence: PVHHLALSCDSLTLSACMMSSEYGSIIAFFDVRTFSNQAKPLKRPFTYHKVSNDASG | ||||||
Repeat | 151-193 | Blade 3 | ||||
Sequence: MVNDMKWNPTVPSMVAVCLADGSISVLQVTDVVKVCATLPPST | ||||||
Repeat | 194-239 | Blade 4 | ||||
Sequence: GVTCVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPPFYESDH | ||||||
Region | 236-1430 | 46 X 2 AA repeats of F-G | ||||
Sequence: ESDHPVRVLDVLWIGTYVFTIVYAGADGTLETCPDVVMALLPKKEEKHPEIFVNFMEPCYSSCTERQHHYYLSYIEEWDLVLAASAASTEVSILARQNDQTNWESWLLEDSSRAELPVTDKSDDSLPMGVAIDYTNEVEVTINEEKTLPPAPVLLLLSTDGVLCPFYMINQNPGVRSLIKTLELISTEGERQPKSSGSFPGTPSSPQAPQNLDAPATASSPLPPVSAAPTSTFPMPSAAGSPSVFSFGPSSFKSSASVTGEPPLYPTGSDSSRAAPGSGTSTFSFAPPSKGSLASTPAVAPVATSAAPFTFGFKPTLESTPMSSTPNTGMKPSFPPSASSVKVNLNEKFTAVASSAPVHSSTSTPSVLPFSSSPKPTASGPLSHPTPLPASSSSMPLKSSVSPSPAAGRSTQTAPSSAPSTGQKSPRVNPPVPKSGSSQAKALQPPVTEKQRPQWKDSDPVLAGIGEEIAHFQKELEELKARTAKACLQVGTSEEMKMLRTESDDLHTFLFEIRETTESLHGDISTLKTTLLEGFAGVEEAREQHGRNHDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDRHLEQKKRQRRLIVPERETLFNTLANNREIINQQRKRLNQLVDSLQQLRLYNHTAPWSLPSALSTQSNSHSFDSDLECLLKTTIESHTKPSPRVPGKLSPAKQAQLRNFLAKRKTPPVRSTAPASLSRSAFLSQRYYEDLDEGSSASSVAQPLEGEDARPTCTSVAQPLEGEDAQPICKEEEAVVPVPRHAPVVRTPSIQPSLLPQSMPFAKPHLIHSSSPAVMSSAVSTSATKVIPQGADSTMLATKTVKHGAPGPSHTVAAPQAAAAAALRRQMASQAPAMSTLTESTLKTVPQVVNVQELRSNPSPPSAAMGSAVQHSAAKTPHAVLTPVANSQAKQGSLINSFKPSGPTAASCQLSSGDKAVGQGTAKTESAATSTPSAAGQLNKPFSFASPGTFTFGTITPTPSSSFTATPGAGPPTKEPTQLEAFSFGGGGKPFSEAIPGNSPATGATSAPSTSVTAASLEDSAPSSSKPAAPPETTVSSASSKLETPPSKLGELLFPSSLAGETLGSFSGLRVGQAEDSTKPVSKASSTNLAGAQPAKPSGVSFPNTSVLGKPVEPAVTSSVSPAPAAPASALNVSTSSSSATVFGSVPLTS | ||||||
Repeat | 240-303 | Blade 5 | ||||
Sequence: PVRVLDVLWIGTYVFTIVYAGADGTLETCPDVVMALLPKKEEKHPEIFVNFMEPCYSSCTERQH | ||||||
Repeat | 304-359 | Blade 6 | ||||
Sequence: HYYLSYIEEWDLVLAASAASTEVSILARQNDQTNWESWLLEDSSRAELPVTDKSDD | ||||||
Repeat | 360-404 | Blade 7 | ||||
Sequence: SLPMGVAIDYTNEVEVTINEEKTLPPAPVLLLLSTDGVLCPFYMI | ||||||
Region | 423-469 | Disordered | ||||
Sequence: EGERQPKSSGSFPGTPSSPQAPQNLDAPATASSPLPPVSAAPTSTFP | ||||||
Region | 479-2071 | 11 X 5 AA approximate repeats | ||||
Sequence: VFSFGPSSFKSSASVTGEPPLYPTGSDSSRAAPGSGTSTFSFAPPSKGSLASTPAVAPVATSAAPFTFGFKPTLESTPMSSTPNTGMKPSFPPSASSVKVNLNEKFTAVASSAPVHSSTSTPSVLPFSSSPKPTASGPLSHPTPLPASSSSMPLKSSVSPSPAAGRSTQTAPSSAPSTGQKSPRVNPPVPKSGSSQAKALQPPVTEKQRPQWKDSDPVLAGIGEEIAHFQKELEELKARTAKACLQVGTSEEMKMLRTESDDLHTFLFEIRETTESLHGDISTLKTTLLEGFAGVEEAREQHGRNHDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDRHLEQKKRQRRLIVPERETLFNTLANNREIINQQRKRLNQLVDSLQQLRLYNHTAPWSLPSALSTQSNSHSFDSDLECLLKTTIESHTKPSPRVPGKLSPAKQAQLRNFLAKRKTPPVRSTAPASLSRSAFLSQRYYEDLDEGSSASSVAQPLEGEDARPTCTSVAQPLEGEDAQPICKEEEAVVPVPRHAPVVRTPSIQPSLLPQSMPFAKPHLIHSSSPAVMSSAVSTSATKVIPQGADSTMLATKTVKHGAPGPSHTVAAPQAAAAAALRRQMASQAPAMSTLTESTLKTVPQVVNVQELRSNPSPPSAAMGSAVQHSAAKTPHAVLTPVANSQAKQGSLINSFKPSGPTAASCQLSSGDKAVGQGTAKTESAATSTPSAAGQLNKPFSFASPGTFTFGTITPTPSSSFTATPGAGPPTKEPTQLEAFSFGGGGKPFSEAIPGNSPATGATSAPSTSVTAASLEDSAPSSSKPAAPPETTVSSASSKLETPPSKLGELLFPSSLAGETLGSFSGLRVGQAEDSTKPVSKASSTNLAGAQPAKPSGVSFPNTSVLGKPVEPAVTSSVSPAPAAPASALNVSTSSSSATVFGSVPLTSAGPPGLISFGGAALASSKASFSFGNQQTSSSTASSATPTSTSVAPSLPASFPTLSFGGLLSSPSASSLPVSSGKSTEEAAPPAVPDKSDSSEVSATTPSLPVQPQSTQASLQTSDPVKKEPVLVQTTDSSPSRPASSASFVASTESMPVTLGAPDSKIEAVSPASTFAGPGQAAVATAVLPGAGSAATEASGTPTTSTVSSSSPTSATETAVFGTATSGSSVFTQPPAASSSSAFSQLSSNTATAPSATPVFGQVAASITSTAAATPQASSSGFGSPAFGASAPGVFGQTAFGQTPAFGQATSSPASGFSFSQPGFSSVPAFGQSVSSTPASTSANVFGATSSTSSPGSFSFGQASTNTGGTLFGQNNPPAFGQSPGFGQGSSVFGGTSATTSTAAPSGFSFCQASGFGSSNTGSVFGQAANTGGSVFGQSSTSSGGVFGSGNATRGGGFFSGLGGKPSQDAANKNPFSSAGGGFGSTAAPNTSNLFGNSGAKTFGGFGSSSFGEQKPAGTFSSGGGSVASQGFGFSTPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSGNTASFGTLASQNAPTFGSLSQQTSGFGTPSSGFAGFGSGTGAFTFG | ||||||
Repeat | 482-483 | 1 | ||||
Sequence: FG | ||||||
Compositional bias | 491-526 | Polar residues | ||||
Sequence: ASVTGEPPLYPTGSDSSRAAPGSGTSTFSFAPPSKG | ||||||
Region | 491-531 | Disordered | ||||
Sequence: ASVTGEPPLYPTGSDSSRAAPGSGTSTFSFAPPSKGSLAST | ||||||
Repeat | 546-547 | 2 | ||||
Sequence: FG | ||||||
Region | 553-574 | Disordered | ||||
Sequence: ESTPMSSTPNTGMKPSFPPSAS | ||||||
Compositional bias | 588-680 | Polar residues | ||||
Sequence: ASSAPVHSSTSTPSVLPFSSSPKPTASGPLSHPTPLPASSSSMPLKSSVSPSPAAGRSTQTAPSSAPSTGQKSPRVNPPVPKSGSSQAKALQP | ||||||
Region | 588-694 | Disordered | ||||
Sequence: ASSAPVHSSTSTPSVLPFSSSPKPTASGPLSHPTPLPASSSSMPLKSSVSPSPAAGRSTQTAPSSAPSTGQKSPRVNPPVPKSGSSQAKALQPPVTEKQRPQWKDSD | ||||||
Coiled coil | 674-1217 | |||||
Sequence: QAKALQPPVTEKQRPQWKDSDPVLAGIGEEIAHFQKELEELKARTAKACLQVGTSEEMKMLRTESDDLHTFLFEIRETTESLHGDISTLKTTLLEGFAGVEEAREQHGRNHDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDRHLEQKKRQRRLIVPERETLFNTLANNREIINQQRKRLNQLVDSLQQLRLYNHTAPWSLPSALSTQSNSHSFDSDLECLLKTTIESHTKPSPRVPGKLSPAKQAQLRNFLAKRKTPPVRSTAPASLSRSAFLSQRYYEDLDEGSSASSVAQPLEGEDARPTCTSVAQPLEGEDAQPICKEEEAVVPVPRHAPVVRTPSIQPSLLPQSMPFAKPHLIHSSSPAVMSSAVSTSATKVIPQGADSTMLATKTVKHGAPGPSHTVAAPQAAAAAALRRQMASQAPAMSTLTESTLKTVPQVVNVQELRSNPSPPSAAMGSAVQHSAAKTPHAVLTPVANSQAKQGSLINSFKPSGPTAASCQLSSGDKAVGQGTAKTESAATSTPSAAGQ | ||||||
Region | 734-762 | Leucine-zipper 1 | ||||
Sequence: LRTESDDLHTFLFEIRETTESLHGDISTL | ||||||
Region | 855-876 | Leucine-zipper 2 | ||||
Sequence: LANNREIINQQRKRLNQLVDSL | ||||||
Region | 1134-1154 | Disordered | ||||
Sequence: LRSNPSPPSAAMGSAVQHSAA | ||||||
Compositional bias | 1174-1248 | Polar residues | ||||
Sequence: LINSFKPSGPTAASCQLSSGDKAVGQGTAKTESAATSTPSAAGQLNKPFSFASPGTFTFGTITPTPSSSFTATPG | ||||||
Region | 1174-1328 | Disordered | ||||
Sequence: LINSFKPSGPTAASCQLSSGDKAVGQGTAKTESAATSTPSAAGQLNKPFSFASPGTFTFGTITPTPSSSFTATPGAGPPTKEPTQLEAFSFGGGGKPFSEAIPGNSPATGATSAPSTSVTAASLEDSAPSSSKPAAPPETTVSSASSKLETPPSK | ||||||
Repeat | 1232-1233 | 3 | ||||
Sequence: FG | ||||||
Repeat | 1264-1265 | 4 | ||||
Sequence: FG | ||||||
Compositional bias | 1278-1324 | Polar residues | ||||
Sequence: NSPATGATSAPSTSVTAASLEDSAPSSSKPAAPPETTVSSASSKLET | ||||||
Region | 1351-1384 | Disordered | ||||
Sequence: VGQAEDSTKPVSKASSTNLAGAQPAKPSGVSFPN | ||||||
Compositional bias | 1358-1384 | Polar residues | ||||
Sequence: TKPVSKASSTNLAGAQPAKPSGVSFPN | ||||||
Region | 1421-2079 | 18 X 4 AA approximate repeats | ||||
Sequence: TVFGSVPLTSAGPPGLISFGGAALASSKASFSFGNQQTSSSTASSATPTSTSVAPSLPASFPTLSFGGLLSSPSASSLPVSSGKSTEEAAPPAVPDKSDSSEVSATTPSLPVQPQSTQASLQTSDPVKKEPVLVQTTDSSPSRPASSASFVASTESMPVTLGAPDSKIEAVSPASTFAGPGQAAVATAVLPGAGSAATEASGTPTTSTVSSSSPTSATETAVFGTATSGSSVFTQPPAASSSSAFSQLSSNTATAPSATPVFGQVAASITSTAAATPQASSSGFGSPAFGASAPGVFGQTAFGQTPAFGQATSSPASGFSFSQPGFSSVPAFGQSVSSTPASTSANVFGATSSTSSPGSFSFGQASTNTGGTLFGQNNPPAFGQSPGFGQGSSVFGGTSATTSTAAPSGFSFCQASGFGSSNTGSVFGQAANTGGSVFGQSSTSSGGVFGSGNATRGGGFFSGLGGKPSQDAANKNPFSSAGGGFGSTAAPNTSNLFGNSGAKTFGGFGSSSFGEQKPAGTFSSGGGSVASQGFGFSTPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSGNTASFGTLASQNAPTFGSLSQQTSGFGTPSSGFAGFGSGTGAFTFGSSNSSVQG | ||||||
Repeat | 1423-1424 | 5 | ||||
Sequence: FG | ||||||
Repeat | 1439-1440 | 6 | ||||
Sequence: FG | ||||||
Region | 1439-2080 | 11 X 3 AA approximate repeats | ||||
Sequence: FGGAALASSKASFSFGNQQTSSSTASSATPTSTSVAPSLPASFPTLSFGGLLSSPSASSLPVSSGKSTEEAAPPAVPDKSDSSEVSATTPSLPVQPQSTQASLQTSDPVKKEPVLVQTTDSSPSRPASSASFVASTESMPVTLGAPDSKIEAVSPASTFAGPGQAAVATAVLPGAGSAATEASGTPTTSTVSSSSPTSATETAVFGTATSGSSVFTQPPAASSSSAFSQLSSNTATAPSATPVFGQVAASITSTAAATPQASSSGFGSPAFGASAPGVFGQTAFGQTPAFGQATSSPASGFSFSQPGFSSVPAFGQSVSSTPASTSANVFGATSSTSSPGSFSFGQASTNTGGTLFGQNNPPAFGQSPGFGQGSSVFGGTSATTSTAAPSGFSFCQASGFGSSNTGSVFGQAANTGGSVFGQSSTSSGGVFGSGNATRGGGFFSGLGGKPSQDAANKNPFSSAGGGFGSTAAPNTSNLFGNSGAKTFGGFGSSSFGEQKPAGTFSSGGGSVASQGFGFSTPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSGNTASFGTLASQNAPTFGSLSQQTSGFGTPSSGFAGFGSGTGAFTFGSSNSSVQGF | ||||||
Repeat | 1453-1454 | 7 | ||||
Sequence: FG | ||||||
Region | 1453-1474 | Disordered | ||||
Sequence: FGNQQTSSSTASSATPTSTSVA | ||||||
Repeat | 1486-1487 | 8 | ||||
Sequence: FG | ||||||
Region | 1495-1575 | Disordered | ||||
Sequence: ASSLPVSSGKSTEEAAPPAVPDKSDSSEVSATTPSLPVQPQSTQASLQTSDPVKKEPVLVQTTDSSPSRPASSASFVASTE | ||||||
Compositional bias | 1519-1575 | Polar residues | ||||
Sequence: DSSEVSATTPSLPVQPQSTQASLQTSDPVKKEPVLVQTTDSSPSRPASSASFVASTE | ||||||
Region | 1615-1636 | Disordered | ||||
Sequence: SAATEASGTPTTSTVSSSSPTS | ||||||
Compositional bias | 1618-1636 | Polar residues | ||||
Sequence: TEASGTPTTSTVSSSSPTS | ||||||
Repeat | 1643-1644 | 9 | ||||
Sequence: FG | ||||||
Repeat | 1682-1683 | 10 | ||||
Sequence: FG | ||||||
Repeat | 1704-1705 | 11 | ||||
Sequence: FG | ||||||
Repeat | 1709-1710 | 12 | ||||
Sequence: FG | ||||||
Repeat | 1717-1718 | 13 | ||||
Sequence: FG | ||||||
Repeat | 1722-1723 | 14 | ||||
Sequence: FG | ||||||
Repeat | 1728-1729 | 15 | ||||
Sequence: FG | ||||||
Repeat | 1752-1753 | 16 | ||||
Sequence: FG | ||||||
Region | 1763-1814 | Disordered | ||||
Sequence: TSANVFGATSSTSSPGSFSFGQASTNTGGTLFGQNNPPAFGQSPGFGQGSSV | ||||||
Repeat | 1768-1769 | 17 | ||||
Sequence: FG | ||||||
Repeat | 1782-1783 | 18 | ||||
Sequence: FG | ||||||
Repeat | 1794-1795 | 19 | ||||
Sequence: FG | ||||||
Repeat | 1802-1803 | 20 | ||||
Sequence: FG | ||||||
Repeat | 1808-1809 | 21 | ||||
Sequence: FG | ||||||
Repeat | 1815-1816 | 22 | ||||
Sequence: FG | ||||||
Repeat | 1838-1839 | 23 | ||||
Sequence: FG | ||||||
Repeat | 1847-1848 | 24 | ||||
Sequence: FG | ||||||
Repeat | 1858-1859 | 25 | ||||
Sequence: FG | ||||||
Repeat | 1869-1870 | 26 | ||||
Sequence: FG | ||||||
Region | 1880-1899 | Disordered | ||||
Sequence: FFSGLGGKPSQDAANKNPFS | ||||||
Repeat | 1905-1906 | 27 | ||||
Sequence: FG | ||||||
Repeat | 1917-1918 | 28 | ||||
Sequence: FG | ||||||
Repeat | 1925-1926 | 29 | ||||
Sequence: FG | ||||||
Repeat | 1928-1929 | 30 | ||||
Sequence: FG | ||||||
Repeat | 1933-1934 | 31 | ||||
Sequence: FG | ||||||
Repeat | 1954-1955 | 32 | ||||
Sequence: FG | ||||||
Repeat | 1965-1966 | 33 | ||||
Sequence: FG | ||||||
Repeat | 1971-1972 | 34 | ||||
Sequence: FG | ||||||
Repeat | 1977-1978 | 35 | ||||
Sequence: FG | ||||||
Repeat | 1983-1984 | 36 | ||||
Sequence: FG | ||||||
Repeat | 1989-1990 | 37 | ||||
Sequence: FG | ||||||
Repeat | 2007-2008 | 38 | ||||
Sequence: FG | ||||||
Repeat | 2019-2020 | 39 | ||||
Sequence: FG | ||||||
Repeat | 2021-2022 | 40 | ||||
Sequence: FG | ||||||
Repeat | 2030-2031 | 41 | ||||
Sequence: FG | ||||||
Repeat | 2041-2042 | 42 | ||||
Sequence: FG | ||||||
Repeat | 2051-2052 | 43 | ||||
Sequence: FG | ||||||
Repeat | 2061-2062 | 44 | ||||
Sequence: FG | ||||||
Repeat | 2070-2071 | 45 | ||||
Sequence: FG | ||||||
Repeat | 2080-2081 | 46 | ||||
Sequence: FG |
Domain
Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited.
The beta-propeller contains long interblade connector loops, and mediates interaction with DDX19B.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,085
- Mass (Da)212,979
- Last updated2008-07-22 v2
- ChecksumC9998CC8BC27EE4A
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A2ATN3 | A2ATN3_MOUSE | Nup214 | 581 | ||
A0A0A6YW83 | A0A0A6YW83_MOUSE | Nup214 | 98 | ||
A0A0A6YY32 | A0A0A6YY32_MOUSE | Nup214 | 147 |
Sequence caution
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 491-526 | Polar residues | ||||
Sequence: ASVTGEPPLYPTGSDSSRAAPGSGTSTFSFAPPSKG | ||||||
Compositional bias | 588-680 | Polar residues | ||||
Sequence: ASSAPVHSSTSTPSVLPFSSSPKPTASGPLSHPTPLPASSSSMPLKSSVSPSPAAGRSTQTAPSSAPSTGQKSPRVNPPVPKSGSSQAKALQP | ||||||
Compositional bias | 1174-1248 | Polar residues | ||||
Sequence: LINSFKPSGPTAASCQLSSGDKAVGQGTAKTESAATSTPSAAGQLNKPFSFASPGTFTFGTITPTPSSSFTATPG | ||||||
Compositional bias | 1278-1324 | Polar residues | ||||
Sequence: NSPATGATSAPSTSVTAASLEDSAPSSSKPAAPPETTVSSASSKLET | ||||||
Compositional bias | 1358-1384 | Polar residues | ||||
Sequence: TKPVSKASSTNLAGAQPAKPSGVSFPN | ||||||
Compositional bias | 1519-1575 | Polar residues | ||||
Sequence: DSSEVSATTPSLPVQPQSTQASLQTSDPVKKEPVLVQTTDSSPSRPASSASFVASTE | ||||||
Compositional bias | 1618-1636 | Polar residues | ||||
Sequence: TEASGTPTTSTVSSSSPTS | ||||||
Sequence conflict | 1973 | in Ref. 1; BAC65471 | ||||
Sequence: S → G |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK122189 EMBL· GenBank· DDBJ | BAC65471.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AL928893 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |