Q80TT2 · BAIP3_MOUSE
- ProteinBAI1-associated protein 3
- GeneBaiap3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1150 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Functions in endosome to Golgi retrograde transport. In response to calcium influx, may interact with SNARE fusion receptors and membrane phospholipids to mediate endosome fusion with the trans-Golgi network. By promoting the recycling of secretory vesicle transmembrane proteins, it indirectly controls dense-core secretory vesicle biogenesis, maturation and their ability to mediate the constitutive and regulated secretion of neurotransmitters and hormones. May regulate behavior and food intake by controlling calcium-stimulated exocytosis of neurotransmitters including NPY and serotonin and hormones like insulin (By similarity).
Proposed to play a role in hypothalamic neuronal firing by modulating gamma-aminobutyric acid (GABA)ergic inhibitory neurotransmission (Probable)
Proposed to play a role in hypothalamic neuronal firing by modulating gamma-aminobutyric acid (GABA)ergic inhibitory neurotransmission (Probable)
Cofactor
Note: Binds 3 Ca2+ ions per C2 domain.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 174 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 180 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 258 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 260 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 1003 | Ca2+ 3 (UniProtKB | ChEBI) | |||
Binding site | 1004 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 1004 | Ca2+ 3 (UniProtKB | ChEBI) | |||
Binding site | 1010 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 1068 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 1068 | Ca2+ 3 (UniProtKB | ChEBI) | |||
Binding site | 1070 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 1070 | Ca2+ 3 (UniProtKB | ChEBI) | |||
Binding site | 1070 | Ca2+ 4 (UniProtKB | ChEBI) | |||
Binding site | 1073 | Ca2+ 4 (UniProtKB | ChEBI) | |||
Binding site | 1076 | Ca2+ 3 (UniProtKB | ChEBI) | |||
Binding site | 1076 | Ca2+ 4 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | GABA-ergic synapse | |
Cellular Component | late endosome membrane | |
Cellular Component | plasma membrane | |
Cellular Component | presynapse | |
Cellular Component | recycling endosome membrane | |
Cellular Component | trans-Golgi network membrane | |
Molecular Function | calcium ion binding | |
Molecular Function | phospholipid binding | |
Molecular Function | SNARE binding | |
Molecular Function | syntaxin binding | |
Biological Process | dense core granule maturation | |
Biological Process | exocytosis | |
Biological Process | G protein-coupled receptor signaling pathway | |
Biological Process | modulation of chemical synaptic transmission | |
Biological Process | positive regulation of insulin secretion involved in cellular response to glucose stimulus | |
Biological Process | positive regulation of neurotransmitter secretion | |
Biological Process | regulation of behavior | |
Biological Process | regulation of dense core granule exocytosis | |
Biological Process | regulation of synaptic transmission, GABAergic | |
Biological Process | retrograde transport, endosome to Golgi |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameBAI1-associated protein 3
- Short namesBAP3
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ80TT2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Recycling endosome membrane ; Peripheral membrane protein
Late endosome membrane ; Peripheral membrane protein
Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein
Cell membrane ; Peripheral membrane protein
Note: Rapidly recruited to the plasma membrane and to Golgi structures in response to increased intracellular calcium concentration.
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Mutant mice are viable, fertile and have overall normal development. Behavioral phenotyping show increased susceptibility to pentylenetetrazole-induced seizures, increased anxiety in females, and benzodiazepine tolerance in males.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 56 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000064820 | 1-1150 | BAI1-associated protein 3 | ||
Proteomic databases
PTM databases
Expression
Tissue specificity
Prominently expressed in brain structures including hypothalamus, amygdala, stria terminalis and periaqueductal gray (at protein level). Expressed in nonneuronal tissues, including placenta, lung, pancreas, spleen, and testes. Within placenta, expression is restricted to the syncytiotrophoblasts.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 22-44 | Disordered | |||
Domain | 139-298 | C2 1 | |||
Region | 193-214 | Disordered | |||
Domain | 626-747 | MHD1 | |||
Domain | 851-959 | MHD2 | |||
Domain | 973-1099 | C2 2 | |||
Sequence similarities
Belongs to the unc-13 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q80TT2-2
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name2
- Length1,150
- Mass (Da)129,069
- Last updated2022-12-14 v4
- MD5 ChecksumE1D2AB8889160CCB57AF68D8CA0312DA
Q80TT2-1
- Name1
- Differences from canonical
- 585-601: ILKVDFFTLTFRQLERL → Q
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0AAA9WUR3 | A0AAA9WUR3_MOUSE | Baiap3 | 653 | ||
E9Q350 | E9Q350_MOUSE | Baiap3 | 1127 | ||
S4R1K2 | S4R1K2_MOUSE | Baiap3 | 1114 | ||
S4R212 | S4R212_MOUSE | Baiap3 | 89 | ||
S4R2U8 | S4R2U8_MOUSE | Baiap3 | 1122 |
Sequence caution
Features
Showing features for sequence conflict, alternative sequence.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 178-179 | in Ref. 2; AAS21653 | |||
Sequence conflict | 182 | in Ref. 2; AAS21653 | |||
Sequence conflict | 197 | in Ref. 2; AAS21653 | |||
Sequence conflict | 200 | in Ref. 2; AAS21653 | |||
Sequence conflict | 359 | in Ref. 2; AAS21653 | |||
Alternative sequence | VSP_061750 | 585-601 | in isoform 1 | ||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK122358 EMBL· GenBank· DDBJ | BAC65640.1 EMBL· GenBank· DDBJ | Transcribed RNA | Sequence problems. | |
AY491413 EMBL· GenBank· DDBJ | AAS21653.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC122454 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |