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Q80TT2 · BAIP3_MOUSE

  • Protein
    BAI1-associated protein 3
  • Gene
    Baiap3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Functions in endosome to Golgi retrograde transport. In response to calcium influx, may interact with SNARE fusion receptors and membrane phospholipids to mediate endosome fusion with the trans-Golgi network. By promoting the recycling of secretory vesicle transmembrane proteins, it indirectly controls dense-core secretory vesicle biogenesis, maturation and their ability to mediate the constitutive and regulated secretion of neurotransmitters and hormones. May regulate behavior and food intake by controlling calcium-stimulated exocytosis of neurotransmitters including NPY and serotonin and hormones like insulin (By similarity).
Proposed to play a role in hypothalamic neuronal firing by modulating gamma-aminobutyric acid (GABA)ergic inhibitory neurotransmission (Probable)

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 3 Ca2+ ions per C2 domain.

Features

Showing features for binding site.

111501002003004005006007008009001,0001,100
TypeIDPosition(s)Description
Binding site174Ca2+ 1 (UniProtKB | ChEBI)
Binding site180Ca2+ 1 (UniProtKB | ChEBI)
Binding site258Ca2+ 1 (UniProtKB | ChEBI)
Binding site260Ca2+ 1 (UniProtKB | ChEBI)
Binding site1003Ca2+ 3 (UniProtKB | ChEBI)
Binding site1004Ca2+ 2 (UniProtKB | ChEBI)
Binding site1004Ca2+ 3 (UniProtKB | ChEBI)
Binding site1010Ca2+ 2 (UniProtKB | ChEBI)
Binding site1068Ca2+ 2 (UniProtKB | ChEBI)
Binding site1068Ca2+ 3 (UniProtKB | ChEBI)
Binding site1070Ca2+ 2 (UniProtKB | ChEBI)
Binding site1070Ca2+ 3 (UniProtKB | ChEBI)
Binding site1070Ca2+ 4 (UniProtKB | ChEBI)
Binding site1073Ca2+ 4 (UniProtKB | ChEBI)
Binding site1076Ca2+ 3 (UniProtKB | ChEBI)
Binding site1076Ca2+ 4 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular ComponentGABA-ergic synapse
Cellular Componentlate endosome membrane
Cellular Componentplasma membrane
Cellular Componentpresynapse
Cellular Componentrecycling endosome membrane
Cellular Componenttrans-Golgi network membrane
Molecular Functioncalcium ion binding
Molecular Functionphospholipid binding
Molecular FunctionSNARE binding
Molecular Functionsyntaxin binding
Biological Processdense core granule maturation
Biological Processexocytosis
Biological ProcessG protein-coupled receptor signaling pathway
Biological Processmodulation of chemical synaptic transmission
Biological Processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
Biological Processpositive regulation of neurotransmitter secretion
Biological Processregulation of behavior
Biological Processregulation of dense core granule exocytosis
Biological Processregulation of synaptic transmission, GABAergic
Biological Processretrograde transport, endosome to Golgi

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    BAI1-associated protein 3
  • Short names
    BAP3
  • Alternative names
    • Brain-specific angiogenesis inhibitor I-associated protein 3
      (Baiap3
      )

Gene names

    • Name
      Baiap3
    • Synonyms
      Gm937, Kiaa0734

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q80TT2
  • Secondary accessions
    • E9QQ76
    • Q6RUT4
    • S4R1E7

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm, cytosol
Recycling endosome membrane
; Peripheral membrane protein
Late endosome membrane
; Peripheral membrane protein
Golgi apparatus, trans-Golgi network membrane
; Peripheral membrane protein
Cell membrane
; Peripheral membrane protein
Note: Rapidly recruited to the plasma membrane and to Golgi structures in response to increased intracellular calcium concentration.

Keywords

Phenotypes & Variants

Disruption phenotype

Mutant mice are viable, fertile and have overall normal development. Behavioral phenotyping show increased susceptibility to pentylenetetrazole-induced seizures, increased anxiety in females, and benzodiazepine tolerance in males.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 56 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000648201-1150BAI1-associated protein 3

Proteomic databases

PTM databases

Expression

Tissue specificity

Prominently expressed in brain structures including hypothalamus, amygdala, stria terminalis and periaqueductal gray (at protein level). Expressed in nonneuronal tissues, including placenta, lung, pancreas, spleen, and testes. Within placenta, expression is restricted to the syncytiotrophoblasts.

Gene expression databases

Interaction

Subunit

Interacts with ADGRB1, this interaction is direct. Interacts with endosomal SNARE proteins VAMP3, VAMP4, STX6 and STX16; this interaction is increased in the presence of calcium.

Protein-protein interaction databases

Miscellaneous

Structure

3D structure databases

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region22-44Disordered
Domain139-298C2 1
Region193-214Disordered
Domain626-747MHD1
Domain851-959MHD2
Domain973-1099C2 2

Sequence similarities

Belongs to the unc-13 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q80TT2-2

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    1,150
  • Mass (Da)
    129,069
  • Last updated
    2022-12-14 v4
  • MD5 Checksum
    E1D2AB8889160CCB57AF68D8CA0312DA
MSTLLDIKSSVLRQVQVCPSFRRKTEQEPEVTNSQEPPTGAWKPGDGVEFFAHMRLILKKGDGRQGLPCPEVLLRSGSPAPAEPVDPNRGLRTLTQEEVEMLYEEALYTVLHRAGTMGPDQVDDEEVLLSYLQQVFGTSSEEHMEAIMRVKKAKAPTYALKVSVMRAKNLLAKDPNGFSDPYCMLGILPASSAPQEPSGQKEQRFGFRKGSKRSSPLPAKCIQVTEVKNSTLNPVWKEHFLFEIDDVNTDQLHLDIWDHDDDVSLAEACRKLNEVIGLKGMTRYFKQIVKSARANGTAGPTEDHTDDFLGCLNIPIREVPVAGADRWFKLEPRSSASRVQGDCHLVLKLITTQRDTVMSQRGRSGFLSYLLLLSRVLRFEHRVEEPNSSSWRGELSGPGTTVLCLHGAQSNLSPLQLAVLHWQVSSRHHQTRTLDYGYLLGLLEDVQAHWEEAASLPQEQEESLADSFSAFSEFGLRLLRQLRDYFPATNSTAVYRLELLLKCLEKLQLFQPAFEICPFETELSMDIAAALKRGNREWYDQLLNTKSPREQPGPQRLAGLVELADIIYEDLQLCYGVYASLFHGILKVDFFTLTFRQLERLVAEEAWVLTEELSPKMNLEVASGLFELYLTLADTQRFWSCIPGRESRSLALAGIHTPFLPAVKLWLQVLRDQAKWRLQGAVDVDTLEPVDAASKHSSSAATASLCLSHIQELWVRLAWPDPSQAQGLGTQLSQDMCEASLFYTELLRKKVDTQPGAAGEAVSEQLCVVLNNVELVRRASGQALRGLAWSEGASGLEGVLPRPLLSCIQALDEDLHREAHTVTAHLTSKMVADIRKYIQHISLSPDSIQNDEAVAPLLKYLDEKLALLNDALVKENLNRVLEALWELLLQAILQALSANRDVSADFYGRFHFTLEALVSFFHAEGQGLPLENLRDGSYKRLQEELRLHKCSTRECIEQFYLDKLKQRSLEQNRFGRLTVRCHYEAAEQRLAVEVLHAADLLPLDANGLSDPFVIVELGPPHLFPLVRSQRTQVKARTLHPVYDELFHFSVPAEACRRRGACVLFTVMDHDWLSTNDFAGEAALGLGGISGIARPHVGGGMRPGQPITLHLRRPRAQVRSALRMLEGRTSREAQEFVKKLKELEKCMEADL

Q80TT2-1

  • Name
    1
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0AAA9WUR3A0AAA9WUR3_MOUSEBaiap3653
E9Q350E9Q350_MOUSEBaiap31127
S4R1K2S4R1K2_MOUSEBaiap31114
S4R212S4R212_MOUSEBaiap389
S4R2U8S4R2U8_MOUSEBaiap31122

Sequence caution

The sequence BAC65640.1 differs from that shown. Reason: Erroneous translation Wrong choice of CDS.

Features

Showing features for sequence conflict, alternative sequence.

Type
IDPosition(s)Description
Sequence conflict178-179in Ref. 2; AAS21653
Sequence conflict182in Ref. 2; AAS21653
Sequence conflict197in Ref. 2; AAS21653
Sequence conflict200in Ref. 2; AAS21653
Sequence conflict359in Ref. 2; AAS21653
Alternative sequenceVSP_061750585-601in isoform 1

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK122358
EMBL· GenBank· DDBJ
BAC65640.1
EMBL· GenBank· DDBJ
Transcribed RNA Sequence problems.
AY491413
EMBL· GenBank· DDBJ
AAS21653.1
EMBL· GenBank· DDBJ
Genomic DNA
AC122454
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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