Q80TL0 · PPM1E_MOUSE

  • Protein
    Protein phosphatase 1E
  • Gene
    Ppm1e
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2. Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42 (By similarity).
Dephosphorylates PRKAA2

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 magnesium or manganese ions per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site270Mn2+ 1 (UniProtKB | ChEBI)
Binding site270Mn2+ 2 (UniProtKB | ChEBI)
Binding site271Mn2+ 1 (UniProtKB | ChEBI)
Binding site432Mn2+ 2 (UniProtKB | ChEBI)
Binding site476Mn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleolus
Cellular Componentnucleoplasm
Cellular Componentnucleus
Cellular Componentprotein-containing complex
Molecular Functionmetal ion binding
Molecular Functionmyosin phosphatase activity
Molecular Functionprotein serine/threonine phosphatase activity
Biological Processcellular response to lipopolysaccharide
Biological Processcellular response to xenobiotic stimulus
Biological Processpositive regulation of stress fiber assembly
Biological Processprotein dephosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein phosphatase 1E
  • EC number
  • Alternative names
    • Ca(2+)/calmodulin-dependent protein kinase phosphatase N (CaMKP-N)
    • CaMKP-nucleus (CaMKN)
    • Partner of PIX 1
    • Partner of PIX-alpha (Partner of PIXA)

Gene names

    • Name
      Ppm1e
    • Synonyms
      Camkn, Kiaa1072

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • OF1
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q80TL0
  • Secondary accessions
    • Q5SX30
    • Q8BGM6
    • Q8CB81

Proteomes

Organism-specific databases

Subcellular Location

Nucleus
Cytoplasm
Note: A truncated form, major form, with the C-terminal part missing, is mostly found in the cytoplasm and a little in the nucleus. The full-length, minor form, is found in the nucleus.

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002868211-749Protein phosphatase 1E
Modified residue532Phosphoserine
Modified residue545Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Heterotrimer. Interacts with PAX1 and ARHGEF6 (or ARHGEF7) (By similarity).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, repeat, compositional bias, domain.

TypeIDPosition(s)Description
Region21-128Disordered
Repeat31-321
Region31-447 X 2 AA tandem repeats of P-E
Repeat33-342
Compositional bias33-47Acidic residues
Repeat35-363
Repeat37-384; approximate
Repeat39-405
Repeat41-426
Repeat43-447
Compositional bias64-102Acidic residues
Compositional bias107-127Pro residues
Domain224-485PPM-type phosphatase
Region495-537Disordered
Compositional bias509-524Basic and acidic residues
Region608-627Disordered

Sequence similarities

Belongs to the PP2C family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    749
  • Mass (Da)
    83,419
  • Last updated
    2007-05-15 v2
  • Checksum
    C59BC6CAC3E268B0
MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPEPESEPEPEPEAELVAAEAAEASGEEPGEDAATVEATEEGEQDQDPEPEDEAVEEETATEGEEEEEEEAAAPGHSAVPPPPQPQLPPLPPLPRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARATSDEVLQSDLSAHCIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQIYYETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASVHLHVNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHKPYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLVASARDAGSSDNITVIVVFLRDMNKAVNVSEESEWTENSFQGGQEDGGDDKETHGECKRPWPQHQCSAPADLGYEGRVDSFTDRTSLSPGPQINVLEDPDYLDLTQIEASKPHSTQFLPPVEMIGPGAPKKDLNELIMEERSVKSSLPERSGAGEPRVSFNLGSTGQQICRMENLSPVSSGLENEQFKSRGKTASRLYHLRHHYSKRQRGFRFNPKFYSFLSAREPSHKIGISLSSLTRSGKRNKMLRSSLPWRENSWEGYSGNVKIRKRNDIPCPDFPWSYKI

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias33-47Acidic residues
Compositional bias64-102Acidic residues
Sequence conflict107in Ref. 1; BAC29490
Compositional bias107-127Pro residues
Compositional bias509-524Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK036583
EMBL· GenBank· DDBJ
BAC29490.1
EMBL· GenBank· DDBJ
mRNA
AK046962
EMBL· GenBank· DDBJ
BAC32927.1
EMBL· GenBank· DDBJ
mRNA
AK053696
EMBL· GenBank· DDBJ
BAC35479.1
EMBL· GenBank· DDBJ
mRNA
AL596130
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AK122434
EMBL· GenBank· DDBJ
BAC65716.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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