Q80TE7 · LRRC7_MOUSE
- ProteinLeucine-rich repeat-containing protein 7
- GeneLrrc7
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1490 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | adherens junction | |
Cellular Component | axon initial segment | |
Cellular Component | basolateral plasma membrane | |
Cellular Component | cytoplasm | |
Cellular Component | dendritic spine | |
Cellular Component | filopodium | |
Cellular Component | glutamatergic synapse | |
Cellular Component | postsynaptic density | |
Cellular Component | postsynaptic density membrane | |
Molecular Function | protein kinase binding | |
Biological Process | cell-cell adhesion | |
Biological Process | establishment or maintenance of epithelial cell apical/basal polarity | |
Biological Process | neurotransmitter receptor transport postsynaptic membrane to endosome | |
Biological Process | neurotransmitter receptor transport, endosome to postsynaptic membrane | |
Biological Process | positive regulation of neuron projection development | |
Biological Process | receptor clustering |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLeucine-rich repeat-containing protein 7
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ80TE7
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Mutant mice are viable and were born at the expected Mendelian ratio, but they have a mortality rate of about 20%. They show early growth retardation. Mutant animals exhibit behavioral abnormalities, including clasping when suspended by the tail, impaired both hippocampus-dependent and hippocampus-independent short-term memories and absence of acoustic prepulse inhibition. They also exhibit significantly higher levels of anxiety. They become hyperactive in response to stress or novelty, but are more sedentary than wild-type in a familiar environment. Males have a profound deficit in nest-making behavior and were aggressive when group-housed, even with littermates.
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000188299 | 1-1490 | Leucine-rich repeat-containing protein 7 | |||
Sequence: MTTKRKLIGRLVPCRCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSSLPTSIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFSELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPPTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQRLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQRVLTNYMFPQQPRGDEDFQSDSDSFNPTLWEEQRQQRMTVAFEFEDKKEDDESAGKVKALSCQAPWDRGQRGITLQPARLSGDCCTPWARCDQQIQDMPVPQSDPQLAWGCISGLQQERSMCAPLPVAAQSTTLPSLSGRQVEINLKRYPTPYPEDLKNMVKSVQNLVGKPSHGVRVENSNPTANTEQTVKEKFEHKWPVAPKEITVEDSFVHPANEMRIGELHPSLAETPLYPPKLVLLGKDKKESTDESEVDKTHCLNNSVSSGTYSDYSPSQASSASSNTRMKVGSLQATAKDAVHNSLWGNRIAPPFPQPLDAKPLLSQREAVPPGNIPQRPDRLPMSDAFPDNWTDGSHYDNTGFVSEEAAGENANNNPLLSSKARSVPAHGRRPLIRQERIVGVPLELEQSTHRHTPETEVPPSNPWQNWTRTPSPFEDRTAFPSKLETTPTTSPLPERKDHMKEPTETPGPFSPGVPWEYHDPTPNRSLGNVFSQIHCRPDSSKGVIAISKSTERLSPLMKDIKSNKFKKSQSIDEIDVGTYKVYNIPLENYASGSDHLGSHERPDKFLGPEHGMSSMSRSQSVPMLDDEMLMYGSSKGPPQQKASMTKKVYQFDQSFNPQGAVEVKAEKRIPPPFAHNSEYVQQPSKNIAKDLVSPRAYRGYPPMEQMFSFSQPSVNEDAMVNAQFASQGPRAGFLRRADSLASSTEMAMFRRVSEPHELPPGDRYGRATYRGGLEGQSSISMTDPQFLKRNGRYEDEHPSYQEVKAQAGSFPAKNLTQRRPLSARSYSTESYGASQTRPVSARPTMAALLEKIPSDYNLGNYGDKTSDNSDIKTRPTPVKGEESCGKMPADWRQQLLRHIEARRLDRTPSQQSNILDNGQEDVSPSGQWNPYPLGRRDVPPDTITKKAGSHIQTLMGSQSLQHRSREQQPYEGNINKVTIQQFQSPLPIQIPSSQATRGPQPGRCLIQTKGQRSMDGYPEQFCVRIEKNPGLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNLLQPGDKILQANGHSFVHMEHEKAVLLLKSFQNTVDLVIQRELTV | ||||||
Modified residue | 439 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 441 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 443 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 831 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 850 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 865 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 869 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 947 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 949 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1118 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1149 | Omega-N-methylarginine | ||||
Sequence: R | ||||||
Modified residue | 1233 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1288 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1392 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in brain (at protein level).
Structure
Family & Domains
Features
Showing features for repeat, region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 23-44 | LRR 1 | ||||
Sequence: IISVLDYSHCSLQQVPKEVFNF | ||||||
Repeat | 47-68 | LRR 2 | ||||
Sequence: TLEELYLDANQIEELPKQLFNC | ||||||
Repeat | 70-91 | LRR 3 | ||||
Sequence: ALRKLSIPDNDLSSLPTSIASL | ||||||
Repeat | 93-114 | LRR 4 | ||||
Sequence: NLKELDISKNGVQEFPENIKCC | ||||||
Repeat | 116-137 | LRR 5 | ||||
Sequence: CLTIIEASVNPISKLPDGFTQL | ||||||
Repeat | 139-161 | LRR 6 | ||||
Sequence: NLTQLYLNDAFLEFLPANFGRLV | ||||||
Repeat | 162-183 | LRR 7 | ||||
Sequence: KLRILELRENHLKTLPKSMHKL | ||||||
Repeat | 185-206 | LRR 8 | ||||
Sequence: QLERLDLGNNEFSELPEVLDQI | ||||||
Repeat | 208-229 | LRR 9 | ||||
Sequence: NLRELWMDNNALQVLPGSIGKL | ||||||
Repeat | 231-253 | LRR 10 | ||||
Sequence: MLVYLDMSKNRIETVDMDISGCE | ||||||
Repeat | 254-275 | LRR 11 | ||||
Sequence: ALEDLLLSSNMLQQLPDSIGLL | ||||||
Repeat | 277-298 | LRR 12 | ||||
Sequence: KLTTLKVDDNQLTMLPNTIGNL | ||||||
Repeat | 300-321 | LRR 13 | ||||
Sequence: LLEEFDCSCNELESLPPTIGYL | ||||||
Repeat | 323-344 | LRR 14 | ||||
Sequence: SLRTLAVDENFLPELPREIGSC | ||||||
Repeat | 346-367 | LRR 15 | ||||
Sequence: NVTVMSLRSNKLEFLPEEIGQM | ||||||
Repeat | 369-391 | LRR 16 | ||||
Sequence: RLRVLNLSDNRLKNLPFSFTKLK | ||||||
Repeat | 392-413 | LRR 17 | ||||
Sequence: ELAALWLSDNQSKALIPLQTEA | ||||||
Region | 663-704 | Disordered | ||||
Sequence: KKESTDESEVDKTHCLNNSVSSGTYSDYSPSQASSASSNTRM | ||||||
Compositional bias | 676-704 | Polar residues | ||||
Sequence: HCLNNSVSSGTYSDYSPSQASSASSNTRM | ||||||
Region | 785-807 | Disordered | ||||
Sequence: AGENANNNPLLSSKARSVPAHGR | ||||||
Region | 822-899 | Disordered | ||||
Sequence: ELEQSTHRHTPETEVPPSNPWQNWTRTPSPFEDRTAFPSKLETTPTTSPLPERKDHMKEPTETPGPFSPGVPWEYHDP | ||||||
Compositional bias | 832-853 | Polar residues | ||||
Sequence: PETEVPPSNPWQNWTRTPSPFE | ||||||
Region | 1134-1158 | Disordered | ||||
Sequence: PHELPPGDRYGRATYRGGLEGQSSI | ||||||
Region | 1196-1218 | Disordered | ||||
Sequence: QRRPLSARSYSTESYGASQTRPV | ||||||
Region | 1238-1265 | Disordered | ||||
Sequence: GNYGDKTSDNSDIKTRPTPVKGEESCGK | ||||||
Region | 1282-1312 | Disordered | ||||
Sequence: RLDRTPSQQSNILDNGQEDVSPSGQWNPYPL | ||||||
Compositional bias | 1285-1305 | Polar residues | ||||
Sequence: RTPSQQSNILDNGQEDVSPSG | ||||||
Domain | 1398-1488 | PDZ | ||||
Sequence: EQFCVRIEKNPGLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNLLQPGDKILQANGHSFVHMEHEKAVLLLKSFQNTVDLVIQREL |
Sequence similarities
Belongs to the LAP (LRR and PDZ) protein family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,490
- Mass (Da)166,901
- Last updated2004-07-19 v2
- ChecksumA27F2892981A2982
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
E9Q6L9 | E9Q6L9_MOUSE | Lrrc7 | 1542 | ||
A0A571BEA5 | A0A571BEA5_MOUSE | Lrrc7 | 1488 | ||
A0A0G2JFZ5 | A0A0G2JFZ5_MOUSE | Lrrc7 | 1531 | ||
A0A0G2JDT9 | A0A0G2JDT9_MOUSE | Lrrc7 | 1495 | ||
B9EHV0 | B9EHV0_MOUSE | Lrrc7 | 1398 |
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 676-704 | Polar residues | ||||
Sequence: HCLNNSVSSGTYSDYSPSQASSASSNTRM | ||||||
Compositional bias | 832-853 | Polar residues | ||||
Sequence: PETEVPPSNPWQNWTRTPSPFE | ||||||
Compositional bias | 1285-1305 | Polar residues | ||||
Sequence: RTPSQQSNILDNGQEDVSPSG |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK122498 EMBL· GenBank· DDBJ | BAC65780.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |