Q80RC7 · GCNT3_BHV4

Function

function

Non-essential glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans. Contributes to the post-translational modifications of structural proteins.

Miscellaneous

Was acquired from an ancestor of the African buffalo around 1.5 million years ago.

Catalytic activity

Pathway

Protein modification; protein glycosylation.

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
  • EC number
  • Alternative names
    • C2GnT-mucin type (C2GnT-M)

Gene names

    • Name
      Bo17

Organism names

Accessions

  • Primary accession
    Q80RC7

Subcellular Location

Host Golgi apparatus membrane
; Single-pass type II membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-11Cytoplasmic
Transmembrane12-29Helical; Signal-anchor for type II membrane protein
Topological domain30-439Lumenal

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00002885511-439Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
Glycosylation71N-linked (GlcNAc...) asparagine; by host
Disulfide bond72↔229
Glycosylation107N-linked (GlcNAc...) asparagine; by host
Disulfide bond163↔383
Disulfide bond184↔211
Disulfide bond392↔424

Keywords

PTM databases

Expression

Developmental stage

Expressed during BHV-4 replication (at protein level).

Structure

3D structure databases

Family & Domains

Sequence similarities

Belongs to the glycosyltransferase 14 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    439
  • Mass (Da)
    50,741
  • Last updated
    2003-06-01 v1
  • Checksum
    70E67B83A41A887D
MVGWKKKKLCRGHHLWVLGCYMLLAVVSLRLSLRFKCDVDSLDLESRDFQSQHCRDMLYNNLKLPAKRSINCSGITRGDQEAVVQALLDNLEVKKKRPPLTDTYYLNITRDCERFKAQRKFIQFPLSKEELDFPIAYSMVVHEKIENFERLLRAVYAPQNIYCVHVDVKSPETFKEAVKAIISCFPNVFMASKLVPVVYASWSRVQADLNCMEDLLQSSVSWKYLLNTCGTDFPIKTNAEMVLALKMLKGKNSMESEVPSESKKNRWKYHYEVTDTLYPTSKMKDPPPDNLPMFTGNAYFVASRAFVQHVLDNPKSQRLVEWVKDTYSPDEHLWATLQRAPWMPGSVPSHPKYHISDMTAVARLVKWQYHEGDVSMGAPYAPCSGIHRRAICIYGAGDLYWILQNHHLLANKFDPRVDDNVLQCLEEYLRHKAIYGTEL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY143158
EMBL· GenBank· DDBJ
AAN18278.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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