Q80966 · Q80966_HPV16

Function

function

Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX-91, a repressor of human telomerase reverse transcriptase (hTERT). The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization. Other cellular targets including BAK1, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis. E6 also inhibits immune response by interacting with host IRF3 and TYK2. These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.

Miscellaneous

Belongs to the high risk human alphapapillomavirus family. The cancer-causing human papillomavirus E6 protein has a unique carboxy terminal PDZ domain containing substrate.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell cytoplasm
Cellular Componenthost cell nucleus
Molecular FunctionDNA binding
Molecular Functionmetal ion binding
Molecular FunctionPDZ domain binding
Biological ProcessDNA-templated transcription
Biological Processregulation of DNA-templated transcription
Biological Processsymbiont-mediated perturbation of host apoptosis
Biological Processsymbiont-mediated perturbation of host ubiquitin-like protein modification
Biological Processsymbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
Biological Processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein E6

Gene names

    • Name
      E6

Organism names

  • Taxonomic identifier
  • Strains
    • AFG7611T
    • HPV16E6/CongoBZV/2014/AB5
    • Af1-ZOAASSOUMOU1
  • Taxonomic lineage
    Viruses > Monodnaviria > Shotokuvirae > Cossaviricota > Papovaviricetes > Zurhausenvirales > Papillomaviridae > Firstpapillomavirinae > Alphapapillomavirus > Alphapapillomavirus 9

Accessions

  • Primary accession
    Q80966
  • Secondary accessions
    • J3XLS2
    • O12650
    • O12651
    • O12652
    • O12925

Subcellular Location

Keywords

Expression

Keywords

Interaction

Subunit

Forms homodimers. Interacts with ubiquitin-protein ligase UBE3A/E6-AP and thus forms a complex with human TP53. Interacts with human NFX1 and MAGI3. Interacts with human IRF3; this interaction inhibits the establishment of antiviral state. Interacts with human TYK2; this interaction inhibits JAK-STAT activation by interferon alpha. Interacts with host DLG1; this interaction leads to the proteasomal degradation of DLG1.

Structure

3D structure databases

Family & Domains

Features

Showing features for zinc finger, motif.

TypeIDPosition(s)Description
Zinc finger30-66
Zinc finger103-139
Motif149-151PDZ-binding domain

Sequence similarities

Belongs to the papillomaviridae E6 protein family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    151
  • Mass (Da)
    18,292
  • Last updated
    1996-11-01 v1
  • Checksum
    35012A9E01993C35
MFQDPQERPTKLPDLCTELQTTIHDIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVCDKCLKFYSKISEYRYYCYSLYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWTGRCMSCCRSSRTRRETQL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF003013
EMBL· GenBank· DDBJ
AAB70730.1
EMBL· GenBank· DDBJ
Genomic DNA
AF003014
EMBL· GenBank· DDBJ
AAB70731.1
EMBL· GenBank· DDBJ
Genomic DNA
AF003017
EMBL· GenBank· DDBJ
AAB70734.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466534
EMBL· GenBank· DDBJ
AGS45283.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466535
EMBL· GenBank· DDBJ
AGS45284.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466536
EMBL· GenBank· DDBJ
AGS45285.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466537
EMBL· GenBank· DDBJ
AGS45286.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466538
EMBL· GenBank· DDBJ
AGS45287.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466539
EMBL· GenBank· DDBJ
AGS45288.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466540
EMBL· GenBank· DDBJ
AGS45289.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466541
EMBL· GenBank· DDBJ
AGS45290.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466542
EMBL· GenBank· DDBJ
AGS45291.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466543
EMBL· GenBank· DDBJ
AGS45292.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466544
EMBL· GenBank· DDBJ
AGS45293.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466545
EMBL· GenBank· DDBJ
AGS45294.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466546
EMBL· GenBank· DDBJ
AGS45295.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466547
EMBL· GenBank· DDBJ
AGS45296.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466548
EMBL· GenBank· DDBJ
AGS45297.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466549
EMBL· GenBank· DDBJ
AGS45298.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466550
EMBL· GenBank· DDBJ
AGS45299.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466551
EMBL· GenBank· DDBJ
AGS45300.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466552
EMBL· GenBank· DDBJ
AGS45301.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466554
EMBL· GenBank· DDBJ
AGS45303.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466555
EMBL· GenBank· DDBJ
AGS45304.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466556
EMBL· GenBank· DDBJ
AGS45305.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466557
EMBL· GenBank· DDBJ
AGS45306.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466558
EMBL· GenBank· DDBJ
AGS45307.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466559
EMBL· GenBank· DDBJ
AGS45308.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466560
EMBL· GenBank· DDBJ
AGS45309.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466561
EMBL· GenBank· DDBJ
AGS45310.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466562
EMBL· GenBank· DDBJ
AGS45311.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466563
EMBL· GenBank· DDBJ
AGS45312.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466564
EMBL· GenBank· DDBJ
AGS45313.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466565
EMBL· GenBank· DDBJ
AGS45314.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466566
EMBL· GenBank· DDBJ
AGS45315.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466567
EMBL· GenBank· DDBJ
AGS45316.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466568
EMBL· GenBank· DDBJ
AGS45317.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466569
EMBL· GenBank· DDBJ
AGS45318.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466570
EMBL· GenBank· DDBJ
AGS45319.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466571
EMBL· GenBank· DDBJ
AGS45320.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466572
EMBL· GenBank· DDBJ
AGS45321.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466573
EMBL· GenBank· DDBJ
AGS45322.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466574
EMBL· GenBank· DDBJ
AGS45323.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466575
EMBL· GenBank· DDBJ
AGS45324.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466576
EMBL· GenBank· DDBJ
AGS45325.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466577
EMBL· GenBank· DDBJ
AGS45326.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466578
EMBL· GenBank· DDBJ
AGS45327.1
EMBL· GenBank· DDBJ
Genomic DNA
KF466653
EMBL· GenBank· DDBJ
AGS45402.1
EMBL· GenBank· DDBJ
Genomic DNA
KP313769
EMBL· GenBank· DDBJ
AKI85227.1
EMBL· GenBank· DDBJ
Genomic DNA
KP677553
EMBL· GenBank· DDBJ
AKN79011.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ388068
EMBL· GenBank· DDBJ
CAB45128.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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