Q803J4 · Q803J4_DANRE

Function

function

Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm6A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Cellular Componentribonucleoprotein complex
Molecular FunctionmRNA 3'-UTR binding
Molecular FunctionRNA binding

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Heterogeneous nuclear ribonucleoprotein C
    • Zgc:55701

Gene names

    • Name
      hnrnpc
    • Synonyms
      bZ1G18.4
      , fb57h12
      , fi16b11
      , wu:fb57h12
      , wu:fi16b11
      , zgc:55701

Organism names

  • Taxonomic identifier
  • Strains
    • AB
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q803J4
  • Secondary accessions
    • Q4V936

Proteomes

    • Identifier
    • Component
      Alternate scaffold 2, Chromosome 2

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain26-97RRM
Region95-116Disordered
Region137-190Disordered
Compositional bias158-190Polar residues
Region218-313Disordered
Compositional bias240-255Basic and acidic residues
Compositional bias256-313Acidic residues

Sequence similarities

Belongs to the RRM HNRPC family. RALY subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    313
  • Mass (Da)
    35,016
  • Last updated
    2003-06-01 v1
  • Checksum
    A057B87529A6A90F
MDRASSASQLIASNVTNKTDPRSLNSRVFIGNLNTMLVTKADVEAIFSKYGKIVGCSVHKGYAFVQFAQERNARTAVQGEDGRMVVGQVLDVNLAGEPKPHRSKTTKRSAGDMYSSSSSFELDYDFQRDYYDRMYSYPSRVPAPPPLSRAVIPSKRPRVSTSGATSRRTKSSFATSSKSSQRTSSRTLKADDLQTIKRELSQIKHKVDFLLESLDRMEKDHGKKSEGKSVKAEVGEVSPLQHSSKKEREREEQEINDSEEERDLLGEEEEEEEEEEVKSQGGENENEEEEGEEEEGEHEEGEDDGDSINGDDS

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8M9Q728A0A8M9Q728_DANREhnrnpc393
A0A8M6Z8V1A0A8M6Z8V1_DANREhnrnpc312
A0A8M9PUR6A0A8M9PUR6_DANREhnrnpc392

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias158-190Polar residues
Compositional bias240-255Basic and acidic residues
Compositional bias256-313Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CR376839
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC044458
EMBL· GenBank· DDBJ
AAH44458.1
EMBL· GenBank· DDBJ
mRNA
BC097078
EMBL· GenBank· DDBJ
AAH97078.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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