Q802X2 · NCOA4_DANRE
- ProteinNuclear receptor coactivator 4
- Genencoa4
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids576 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Cargo receptor for the autophagic turnover of ferritin (By similarity).
Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation of ferritin, a process named ferritinophagy (By similarity).
Plays a role in erythropoiesis, possibly by regulating hemin-induced erythroid differentiation (PubMed:26436293).
Binds chromatin before initiation of DNA replication and detaches during replication (By similarity).
Inhibits activation of DNA replication origins, possibly by obstructing DNA unwinding via interaction with the MCM2-7 complex (By similarity).
Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation of ferritin, a process named ferritinophagy (By similarity).
Plays a role in erythropoiesis, possibly by regulating hemin-induced erythroid differentiation (PubMed:26436293).
Binds chromatin before initiation of DNA replication and detaches during replication (By similarity).
Inhibits activation of DNA replication origins, possibly by obstructing DNA unwinding via interaction with the MCM2-7 complex (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | autolysosome | |
Cellular Component | autophagosome | |
Cellular Component | chromosome | |
Cellular Component | cytoplasmic vesicle | |
Cellular Component | nucleus | |
Molecular Function | transcription coactivator activity | |
Biological Process | erythrocyte differentiation | |
Biological Process | intracellular iron ion homeostasis | |
Biological Process | response to hormone |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameNuclear receptor coactivator 4
- Short namesNCoA-4
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ802X2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Morpholino-mediated knockdown severely disrupts erythropoiesis.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000460476 | 1-576 | Nuclear receptor coactivator 4 | |||
Sequence: MSPMGQREKAALRQCIQARAQLDEAIADIIKAEVQLKSNSREVKSQLHSCISRHLEILRSREVWLLEQIDLVEQLKGETLHQQLQQLHSLKGQFDLLIHQLEYSGSNSLTTQLTDCLEKLSSLNLTPEETPEMSFQADAHTLRKAITSFGTIASEQMETSESFARPWLLQDCPVFFKKQKLDPERTTPLTEWLLGNHPVCSAPVKYHFSTNPHDWLLVSKESQEEKQLPAFDFQKAWGQLHDLESWLLKEKLPIRKRTCSSSSTFSIEMIDESDFNLDDVEDEQEKASDTFEKEELNKWLVNSSLVKPNQTNPDAERFKQIFKPFYESFSSSDWLSKSDCGSCCATRTTAVEIENLGKLKCLKTPPPSTPVTTPDPMEMWLHKTIPLESTCKANETCTSYAQCVCEDNCGKEALSAWLLKKEGRDKNGVPVNKNSTSKASSHQQEQQQKVQAILEAWLHPSNSAKSPDLTSLSAWAIPHIKLADPENSVENPLQAENWLHPAIKQISSATEMPNKAESKSAKDQDGKDNVEEDKWLLRKRVSAQERLGLPIVCDLFSCMKLGGDKEKWLHQAATQI |
Proteomic databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 425-447 | Disordered | ||||
Sequence: DKNGVPVNKNSTSKASSHQQEQQ | ||||||
Compositional bias | 429-447 | Polar residues | ||||
Sequence: VPVNKNSTSKASSHQQEQQ | ||||||
Region | 510-529 | Disordered | ||||
Sequence: TEMPNKAESKSAKDQDGKDN |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length576
- Mass (Da)65,243
- Last updated2003-06-01 v1
- Checksum4A6F6318B9196F4E
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 115 | in Ref. 2; CU019624/AAH65638 | ||||
Sequence: D → N | ||||||
Sequence conflict | 293 | in Ref. 2; CU019624/AAH65638 | ||||
Sequence: K → E | ||||||
Compositional bias | 429-447 | Polar residues | ||||
Sequence: VPVNKNSTSKASSHQQEQQ |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CU019624 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC047166 EMBL· GenBank· DDBJ | AAH47166.1 EMBL· GenBank· DDBJ | mRNA | ||
BC165720 EMBL· GenBank· DDBJ | AAI65720.1 EMBL· GenBank· DDBJ | mRNA | ||
BC065638 EMBL· GenBank· DDBJ | AAH65638.1 EMBL· GenBank· DDBJ | mRNA |