Q802X2 · NCOA4_DANRE

Function

function

Cargo receptor for the autophagic turnover of ferritin (By similarity).
Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation of ferritin, a process named ferritinophagy (By similarity).
Plays a role in erythropoiesis, possibly by regulating hemin-induced erythroid differentiation (PubMed:26436293).
Binds chromatin before initiation of DNA replication and detaches during replication (By similarity).
Inhibits activation of DNA replication origins, possibly by obstructing DNA unwinding via interaction with the MCM2-7 complex (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentautolysosome
Cellular Componentautophagosome
Cellular Componentchromosome
Cellular Componentcytoplasmic vesicle
Cellular Componentnucleus
Molecular Functiontranscription coactivator activity
Biological Processerythrocyte differentiation
Biological Processintracellular iron ion homeostasis
Biological Processresponse to hormone

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Nuclear receptor coactivator 4
  • Short names
    NCoA-4
  • Alternative names
    • Ferritin cargo receptor NCOA4

Gene names

    • Name
      ncoa4
    • Synonyms
      zgc:55307
      , zgc:77270

Organism names

  • Taxonomic identifier
  • Strains
    • AB
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q802X2
  • Secondary accessions
    • A0A8M2B394
    • Q6P0F7

Proteomes

Organism-specific databases

Subcellular Location

Phenotypes & Variants

Disruption phenotype

Morpholino-mediated knockdown severely disrupts erythropoiesis.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004604761-576Nuclear receptor coactivator 4

Proteomic databases

Expression

Tissue specificity

Expressed in the intermediate cell mass (ICM) at 24 hpf (hours post-fertilization) (PubMed:26436293).
At 48 and 72 hpf, expressed in circulating erythrocytes visible in the yolk sac, heart, and liver (PubMed:26436293).

Gene expression databases

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region425-447Disordered
Compositional bias429-447Polar residues
Region510-529Disordered

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    576
  • Mass (Da)
    65,243
  • Last updated
    2003-06-01 v1
  • Checksum
    4A6F6318B9196F4E
MSPMGQREKAALRQCIQARAQLDEAIADIIKAEVQLKSNSREVKSQLHSCISRHLEILRSREVWLLEQIDLVEQLKGETLHQQLQQLHSLKGQFDLLIHQLEYSGSNSLTTQLTDCLEKLSSLNLTPEETPEMSFQADAHTLRKAITSFGTIASEQMETSESFARPWLLQDCPVFFKKQKLDPERTTPLTEWLLGNHPVCSAPVKYHFSTNPHDWLLVSKESQEEKQLPAFDFQKAWGQLHDLESWLLKEKLPIRKRTCSSSSTFSIEMIDESDFNLDDVEDEQEKASDTFEKEELNKWLVNSSLVKPNQTNPDAERFKQIFKPFYESFSSSDWLSKSDCGSCCATRTTAVEIENLGKLKCLKTPPPSTPVTTPDPMEMWLHKTIPLESTCKANETCTSYAQCVCEDNCGKEALSAWLLKKEGRDKNGVPVNKNSTSKASSHQQEQQQKVQAILEAWLHPSNSAKSPDLTSLSAWAIPHIKLADPENSVENPLQAENWLHPAIKQISSATEMPNKAESKSAKDQDGKDNVEEDKWLLRKRVSAQERLGLPIVCDLFSCMKLGGDKEKWLHQAATQI

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict115in Ref. 2; CU019624/AAH65638
Sequence conflict293in Ref. 2; CU019624/AAH65638
Compositional bias429-447Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CU019624
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC047166
EMBL· GenBank· DDBJ
AAH47166.1
EMBL· GenBank· DDBJ
mRNA
BC165720
EMBL· GenBank· DDBJ
AAI65720.1
EMBL· GenBank· DDBJ
mRNA
BC065638
EMBL· GenBank· DDBJ
AAH65638.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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