Q801X6 · PHAR1_CHICK

  • Protein
    Phosphatase and actin regulator 1
  • Gene
    PHACTR1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Binds actin monomers (G actin) and plays a role in the reorganization of the actin cytoskeleton and in formation of actin stress fibers.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentnucleus
Cellular Componentsynapse
Molecular Functionactin binding
Molecular Functionprotein phosphatase inhibitor activity
Biological Processactin cytoskeleton organization
Biological Processactomyosin structure organization
Biological Processcell motility
Biological Processstress fiber assembly

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Phosphatase and actin regulator 1

Gene names

    • Name
      PHACTR1
    • Synonyms
      DDSG1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus

Accessions

  • Primary accession
    Q801X6

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Synapse
Nucleus
Note: Enriched at synapses (By similarity).
Cytoplasmic in resting cells, and is imported into the nucleus upon serum stimulation. Interaction with actin prevents nuclear import (By similarity).

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002359911-501Phosphatase and actin regulator 1

Proteomic databases

Expression

Tissue specificity

Expressed in the gizzard, and in neurons from central and peripheral nervous systems.

Interaction

Subunit

Interacts (via RPEL repeats) with ACTA1.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for repeat, region, compositional bias.

TypeIDPosition(s)Description
Repeat1-18RPEL 1
Region21-46Disordered
Compositional bias295-313Basic and acidic residues
Region295-329Disordered
Compositional bias314-329Acidic residues
Repeat343-368RPEL 2
Repeat381-406RPEL 3
Region382-415Disordered
Compositional bias388-415Basic and acidic residues
Repeat419-444RPEL 4

Domain

Binds three actin monomers via the three C-terminal RPEL repeats.

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    501
  • Mass (Da)
    56,095
  • Last updated
    2003-06-01 v1
  • Checksum
    B5607F04F5E29ECA
MRQSREELIKRGVLKEIFDKDGELSIPNEEGALENGQPLGSGQVLSSSQVSLPALAELESGSAPGEPCSYEVLPTTEITDGTVSEESPTSNESGVLLSQDPTAKPVLLLPPKKSAAFPGDHEDTPVKQLSLLKQPPALPPKPIARIASHLTDPGAPVKLPCMPVKLSPPLPPKKVMICMPLGGPDLSSLSSYSTQKSSQQPLTQHHHTVLPSQLAAHQHQLQYGSHSQHLPSGSSTLPIHPSGCRMIEELNKTLAMTMQRLESSGLHTGDNVTKTGPGGLPDMRQVPTVVIECDDNKENVPHEADYEDSSCLYPRQEEEEEEDEDEDNSLFTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPMQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQEEKREIKRRLTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADKPWTRLTAADKAAIRKELNEFKSSEMEVHELSRHLTRFHRP

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias295-313Basic and acidic residues
Compositional bias314-329Acidic residues
Compositional bias388-415Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB100407
EMBL· GenBank· DDBJ
BAC67215.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp