Q801D8 · MPRA_CYNNE
- ProteinMembrane progestin receptor alpha
- Genempra
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids352 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Steroid membrane receptor. Binds progesterone, progestin and 17-hydroxyprogesterone in vitro. Capable of mediating progestin-induced oocyte maturation (By similarity).
Miscellaneous
May activate a pertussis toxin-sensitive inhibitory G protein that inhibits adenylate cyclase activity; it may therefore be a G-protein coupled receptor.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | nuclear steroid receptor activity | |
Molecular Function | steroid binding | |
Biological Process | oogenesis |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameMembrane progestin receptor alpha
- Short namesmPR alpha
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Sciaenidae > Cynoscion
Accessions
- Primary accessionQ801D8
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Note: Localized to the cell membrane of oocytes and sperm.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Topological domain | 1-75 | Cytoplasmic | |||
Transmembrane | 76-96 | Helical; Name=1 | |||
Topological domain | 97-110 | Extracellular | |||
Transmembrane | 111-131 | Helical; Name=2 | |||
Topological domain | 132-139 | Cytoplasmic | |||
Transmembrane | 140-160 | Helical; Name=3 | |||
Topological domain | 161-175 | Extracellular | |||
Transmembrane | 176-196 | Helical; Name=4 | |||
Topological domain | 197-242 | Cytoplasmic | |||
Transmembrane | 243-263 | Helical; Name=5 | |||
Topological domain | 264-275 | Extracellular | |||
Transmembrane | 276-296 | Helical; Name=6 | |||
Topological domain | 297-316 | Cytoplasmic | |||
Transmembrane | 317-337 | Helical; Name=7 | |||
Topological domain | 338-352 | Extracellular | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000218839 | 1-352 | Membrane progestin receptor alpha | ||
Expression
Tissue specificity
Strongly expressed in ovary and brain; lower expression in testis and pituitary. Not detected in heart, kidney, spleen, intestine, gill and muscle.
Induction
By progestin in ovarian tissues and human chorionic gonadotropin (hCG) in oocytes undergoing meiotic maturation.
Developmental stage
Expressed at low expression in fully grown oocytes, highly expressed in maturing oocytes undergoing germinal vesicle breakdown (GVBD) and weakly expressed in ovulated oocytes.
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length352
- Mass (Da)40,585
- Last updated2003-06-01 v1
- Checksum8E7B288FF5557697
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF262028 EMBL· GenBank· DDBJ | AAO39265.1 EMBL· GenBank· DDBJ | mRNA |