Q801D8 · MPRA_CYNNE

Function

function

Steroid membrane receptor. Binds progesterone, progestin and 17-hydroxyprogesterone in vitro. Capable of mediating progestin-induced oocyte maturation (By similarity).

Miscellaneous

May activate a pertussis toxin-sensitive inhibitory G protein that inhibits adenylate cyclase activity; it may therefore be a G-protein coupled receptor.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functionnuclear steroid receptor activity
Molecular Functionsteroid binding
Biological Processoogenesis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Membrane progestin receptor alpha
  • Short names
    mPR alpha
  • Alternative names
    • Membrane progesterone receptor

Gene names

    • Name
      mpra

Organism names

Accessions

  • Primary accession
    Q801D8

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Note: Localized to the cell membrane of oocytes and sperm.

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-75Cytoplasmic
Transmembrane76-96Helical; Name=1
Topological domain97-110Extracellular
Transmembrane111-131Helical; Name=2
Topological domain132-139Cytoplasmic
Transmembrane140-160Helical; Name=3
Topological domain161-175Extracellular
Transmembrane176-196Helical; Name=4
Topological domain197-242Cytoplasmic
Transmembrane243-263Helical; Name=5
Topological domain264-275Extracellular
Transmembrane276-296Helical; Name=6
Topological domain297-316Cytoplasmic
Transmembrane317-337Helical; Name=7
Topological domain338-352Extracellular

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002188391-352Membrane progestin receptor alpha

Expression

Tissue specificity

Strongly expressed in ovary and brain; lower expression in testis and pituitary. Not detected in heart, kidney, spleen, intestine, gill and muscle.

Induction

By progestin in ovarian tissues and human chorionic gonadotropin (hCG) in oocytes undergoing meiotic maturation.

Developmental stage

Expressed at low expression in fully grown oocytes, highly expressed in maturing oocytes undergoing germinal vesicle breakdown (GVBD) and weakly expressed in ovulated oocytes.

Structure

Family & Domains

Sequence similarities

Belongs to the ADIPOR family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    352
  • Mass (Da)
    40,585
  • Last updated
    2003-06-01 v1
  • Checksum
    8E7B288FF5557697
MATVVMEQIGRLFINAQQLRQIPQLLESAFPTLPCTVKVSDVPWVFRERHILTGYRQPDQSWRYYFLTLFQRHNETLNVWTHLLAAFIILVKWQEISETVDFLRDPHAQPLFIVLLAAFTYLSFSALAHLLSAKSELSYYTFYFLDYVGVAVYQYGSALAHYYYAIEKEWHTKVQGLFLPAAAFLAWLTCFGCCYGKYASPELPKVANKLFQVVPSALAYCLDISPVVHRIYSCYQEGCSDPVVAYHFYHVVFFLIGAYFFCCPHPESLFPGKCDFIGQGHQLFHVFVVVCTLTQVEALRTDFTERRPFYERLHGDLAHDAVALFIFTACCSALTAFYVRQRVRASLHEKGE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF262028
EMBL· GenBank· DDBJ
AAO39265.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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