Q7ZXH1 · DHCR7_XENLA

Function

function

Catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core (By similarity).
Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta24-sterol reductase (DHCR24) to cholesterol (By similarity).
Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation (By similarity).

Catalytic activity

Pathway

Steroid biosynthesis; cholesterol biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site356NADP+ (UniProtKB | ChEBI)
Binding site360NADP+ (UniProtKB | ChEBI)
Binding site393NADP+ (UniProtKB | ChEBI)
Binding site398NADP+ (UniProtKB | ChEBI)
Binding site405-406NADP+ (UniProtKB | ChEBI)
Binding site445NADP+ (UniProtKB | ChEBI)
Binding site449-453NADP+ (UniProtKB | ChEBI)
Binding site460NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Function7-dehydrocholesterol reductase activity
Molecular FunctionNADP binding
Biological Processcholesterol biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    7-dehydrocholesterol reductase
  • EC number
  • Short names
    7-DHC reductase
  • Alternative names
    • Sterol Delta(7)-reductase

Gene names

    • Name
      dhcr7

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus

Accessions

  • Primary accession
    Q7ZXH1

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane36-56Helical
Transmembrane97-117Helical
Transmembrane175-195Helical
Transmembrane264-284Helical
Transmembrane304-324Helical
Transmembrane329-349Helical
Transmembrane419-439Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002075061-4737-dehydrocholesterol reductase

Expression

Gene expression databases

    • 379273Expressed in neurula embryo and 19 other cell types or tissues

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-20Disordered

Sequence similarities

Belongs to the ERG4/ERG24 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    473
  • Mass (Da)
    54,823
  • Last updated
    2003-06-01 v1
  • Checksum
    8EB14E8186BDC463
MGERRRANASRGDKKVANGEKQHVGQWGRAWEVDYFSLASVIFLLAFAPLIVYYFVMSCDQYQCALTAPVLDLYSGKARLSDIWDKTPALTWTAVKIYLAWVSFQVFLYMFLPDILHKFVPGYEGGVQEGARTPAGLINKYQVNGLQAWTITHLLWFANAYHFHWFSPTIVIDNWIPLLWCANLLGYSVATFALVKANFFPTNANDCKFTGNFFYDYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSYAAKQQELYGQVTNSMILVNVLQAIYVVDFFWNESWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYNPVELSTTAAVAVLLLGLIGYYIFRMTNHQKDLFRRTNGNCKIWGKKPKSIECFYVSADGKRHYSKLMISGFWGVARHLNYTGDLMGSLAYCLACGFDHLLPYFYFIYMTILLVHRCIRDEHRCSSKYGKDWKLYTSAVPYRLLPGLF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC044995
EMBL· GenBank· DDBJ
AAH44995.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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