Q7ZVW7 · Q7ZVW7_DANRE
- ProteinInterleukin-1 receptor-associated kinase 4
- Geneirak4
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids382 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | magnesium ion binding | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | cell surface receptor signaling pathway | |
Biological Process | innate immune response | |
Biological Process | positive regulation of canonical NF-kappaB signal transduction | |
Biological Process | positive regulation of defense response | |
Biological Process | positive regulation of DNA-templated transcription | |
Biological Process | response to bacterium |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameInterleukin-1 receptor-associated kinase 4
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ7ZVW7
Proteomes
Organism-specific databases
Subcellular Location
Interaction
Subunit
Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 137-156 | Disordered | ||||
Sequence: DNSNKPQKISKPVEDDSNKP | ||||||
Domain | 204-382 | Protein kinase | ||||
Sequence: SDGGCRLGSGGFGVVFRGRMGDKHVAVKKLNPLDGSSYEDLRKQFNQEIQTLRSLSHENVLRVLGCSCSGPPLCVVFELMVNGSLLERLACAEHTPALTWRNRCWITVGAARGLSYLHTHAHIHRDVKSANILLDEGFVAKISDFGLTRSAAAGAAGGFVWASSSGRESGSCTVAGDEG |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length382
- Mass (Da)41,769
- Last updated2003-06-01 v1
- Checksum2FDFD6B572B4CB2B
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC045381 EMBL· GenBank· DDBJ | AAH45381.1 EMBL· GenBank· DDBJ | mRNA | ||
BC164777 EMBL· GenBank· DDBJ | AAI64777.1 EMBL· GenBank· DDBJ | mRNA |