Q7ZVN0 · Q7ZVN0_DANRE
- ProteinElongation of very long chain fatty acids protein 7
- Geneelovl7a
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids288 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Catalytic activity
- a very-long-chain acyl-CoA + malonyl-CoA + H+ = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA
Pathway
Lipid metabolism; fatty acid biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | fatty acid elongase activity | |
Biological Process | fatty acid elongation, monounsaturated fatty acid | |
Biological Process | fatty acid elongation, polyunsaturated fatty acid | |
Biological Process | fatty acid elongation, saturated fatty acid | |
Biological Process | long-chain fatty-acyl-CoA biosynthetic process | |
Biological Process | sphingolipid biosynthetic process | |
Biological Process | unsaturated fatty acid biosynthetic process | |
Biological Process | very long-chain fatty acid biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameElongation of very long chain fatty acids protein 7
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ7ZVN0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 35-56 | Helical | ||||
Sequence: IPQMLIIVFYIYFVISLGPKIM | ||||||
Transmembrane | 68-87 | Helical | ||||
Sequence: LIVYNIFVVSLSVYMCYEFL | ||||||
Transmembrane | 118-136 | Helical | ||||
Sequence: WLYYFSKFIVMLDTVFFVL | ||||||
Transmembrane | 143-160 | Helical | ||||
Sequence: ITFLHVFHHSIMPFTWWF | ||||||
Transmembrane | 172-190 | Helical | ||||
Sequence: FHALLNCIVHVIMYTYYLL | ||||||
Transmembrane | 210-227 | Helical | ||||
Sequence: LQLIQFVLVTVHISQYFF | ||||||
Transmembrane | 233-257 | Helical | ||||
Sequence: YPYPLFMYIIALYGIIFLLLFLNFW |
Keywords
- Cellular component
Structure
Family & Domains
Sequence similarities
Belongs to the ELO family. ELOVL7 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length288
- Mass (Da)34,214
- Last updated2003-06-01 v1
- ChecksumEF3F88DC4240BB82
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC045481 EMBL· GenBank· DDBJ | AAH45481.1 EMBL· GenBank· DDBJ | mRNA |