Q7ZVN0 · Q7ZVN0_DANRE

Function

function

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Lipid metabolism; fatty acid biosynthesis.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionfatty acid elongase activity
Biological Processfatty acid elongation, monounsaturated fatty acid
Biological Processfatty acid elongation, polyunsaturated fatty acid
Biological Processfatty acid elongation, saturated fatty acid
Biological Processlong-chain fatty-acyl-CoA biosynthetic process
Biological Processsphingolipid biosynthetic process
Biological Processunsaturated fatty acid biosynthetic process
Biological Processvery long-chain fatty acid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Elongation of very long chain fatty acids protein 7
  • EC number
  • Alternative names
    • 3-keto acyl-CoA synthase ELOVL7
    • ELOVL fatty acid elongase 7
      (ELOVL FA elongase 7
      )
    • Very long chain 3-ketoacyl-CoA synthase 7
    • Very long chain 3-oxoacyl-CoA synthase 7

Gene names

    • Name
      elovl7a
    • Synonyms
      ELOVL7
      , elovl7
      , fi36f02
      , wu:fi36f02
      , zgc:55879

Organism names

  • Taxonomic identifier
  • Strain
    • AB
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q7ZVN0

Proteomes

    • Identifier
    • Component
      Alternate scaffold 8, Chromosome 8

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane35-56Helical
Transmembrane68-87Helical
Transmembrane118-136Helical
Transmembrane143-160Helical
Transmembrane172-190Helical
Transmembrane210-227Helical
Transmembrane233-257Helical

Keywords

Family & Domains

Sequence similarities

Belongs to the ELO family. ELOVL7 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    288
  • Mass (Da)
    34,214
  • Last updated
    2003-06-01 v1
  • Checksum
    EF3F88DC4240BB82
MAFQEFTSTAVQLFDKWMESSDPRTKGWLLMSNPIPQMLIIVFYIYFVISLGPKIMENRKPFDLKRVLIVYNIFVVSLSVYMCYEFLMAGWGTGYTFGCDLVDYSQSPKAMRMASVCWLYYFSKFIVMLDTVFFVLRKKPKQITFLHVFHHSIMPFTWWFGVRFSPGGLGTFHALLNCIVHVIMYTYYLLSALGPSFQRFLWWKKHLTSLQLIQFVLVTVHISQYFFMKDCPYPYPLFMYIIALYGIIFLLLFLNFWHHAYTKGKRLPKILQKTISPKNNNDIHHKKE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC045481
EMBL· GenBank· DDBJ
AAH45481.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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