Q7ZTU9 · TBX2_DANRE
- ProteinT-box transcription factor TBX2b
- Genetbx2b
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids687 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Transcription factor which acts as a transcriptional repressor (By similarity).
May also function as a transcriptional activator (By similarity).
Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (By similarity).
Involved in the transcriptional regulation of genes required for mesoderm differentiation. Plays a role in the specification of late notochordal precursor cells and formation of the differentiated notochord. Required for cardiac atrioventricular canal formation
May also function as a transcriptional activator (By similarity).
Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (By similarity).
Involved in the transcriptional regulation of genes required for mesoderm differentiation. Plays a role in the specification of late notochordal precursor cells and formation of the differentiated notochord. Required for cardiac atrioventricular canal formation
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 103-276 | T-box | ||||
Sequence: LWDQFHKLGTEMVITKSGRRMFPPFKVRINGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRD |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameT-box transcription factor TBX2b
- Short namesT-box protein 2b
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ7ZTU9
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Loss of atrioventricular canal formation and cardiac looping.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000262463 | 1-687 | T-box transcription factor TBX2b | |||
Sequence: MRDPVFTGTAMAYHPFHAHRPTDFPMSAFLAAAQPSFFPALTLPPGALTKPIPDHTLAGAAEAGLHPALSHHHQAAHLRSLKSLEPEEEVEDDPKVTLEAKDLWDQFHKLGTEMVITKSGRRMFPPFKVRINGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLPSLRMYEDQCKVDRDGADSDASSSEPTTGRDAGHSPGPVSSPLRFNRGSRDDKTCTDSEHEMDHQNDRCGGSSSPAPEPSSPFRSRSEDWGREKPIAEKKDDYPDSRKTSDSIFSIRNLEKDKLESRSRKDTDSSKKDTENSGISGSKDSFSPLMVQTESPSHFGAGHLQSLALSGLHSQQFFNPLNTGQPLLFHPGQFAMAPGAFSAMGMGHLLASVSGAGGLENGSLSAQGTGSTPSPFPFHLSQHMLASQGIPMPTFGGLFPYPYTYMAAAAAAASALPASSSTASSLSRNPFLSSSTRPRLRFNPYQLPVSIPQSTNLLTTGLPSGLNPSSESSKCGSREASPVPDHKSGASQRNGSPKTTMKESINELQNIQRLVSGLESQRETSSPRDSPK |
Proteomic databases
Expression
Tissue specificity
Expressed in the axial mesoderm, notably, in the notochordal precursor cells immediately before formation of the notochord and in the chordoneural hinge of the tail bud, after the notochord is formed. In addition, its expression is detected in the ventral forebrain, sensory neurons, fin buds and excretory system.
Developmental stage
Expression seen in many tissues of ectodermal and mesodermal origin during embryogenesis. First detected at bud stage in the ventral prosencephalon and along the length of the notochord. As segmentation proceeds, expressed in the optic primordia, otic placodes and diffusely in cells over the yolk lying ventrally to the tail bud. Midway through the segmentation period, expression also seen in the acostic and lateral line sensory ganglia. At 22 hpf, found in the most posterior portion of the pronephric ducts (PubMed:10664151).
At the end of gastrulation, expression seen in the prospective ventral forebrain, single eye field and the presumptive notochord. At 12 hpf, expression in the midline found only at the posterior end of the notochord where it can be detected until the end of segmentation. At 20 hpf, expression in the eye is restricted to the dorsal retina and also found in the epiphysis, otic vesicles and sensory neurons of cranial ganglia. At 22 hpf, expressed in bud of pectoral fins and at 30 hpf, in a subset of interneurons in the anterior spinal cord (PubMed:10331981).
At the end of gastrulation, expression seen in the prospective ventral forebrain, single eye field and the presumptive notochord. At 12 hpf, expression in the midline found only at the posterior end of the notochord where it can be detected until the end of segmentation. At 20 hpf, expression in the eye is restricted to the dorsal retina and also found in the epiphysis, otic vesicles and sensory neurons of cranial ganglia. At 22 hpf, expressed in bud of pectoral fins and at 30 hpf, in a subset of interneurons in the anterior spinal cord (PubMed:10331981).
Gene expression databases
Interaction
Structure
Family & Domains
Features
Showing features for region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 303-452 | Disordered | ||||
Sequence: DRDGADSDASSSEPTTGRDAGHSPGPVSSPLRFNRGSRDDKTCTDSEHEMDHQNDRCGGSSSPAPEPSSPFRSRSEDWGREKPIAEKKDDYPDSRKTSDSIFSIRNLEKDKLESRSRKDTDSSKKDTENSGISGSKDSFSPLMVQTESPS | ||||||
Compositional bias | 336-357 | Basic and acidic residues | ||||
Sequence: NRGSRDDKTCTDSEHEMDHQND | ||||||
Compositional bias | 375-428 | Basic and acidic residues | ||||
Sequence: SRSEDWGREKPIAEKKDDYPDSRKTSDSIFSIRNLEKDKLESRSRKDTDSSKKD | ||||||
Compositional bias | 429-452 | Polar residues | ||||
Sequence: TENSGISGSKDSFSPLMVQTESPS | ||||||
Compositional bias | 611-632 | Polar residues | ||||
Sequence: NLLTTGLPSGLNPSSESSKCGS | ||||||
Region | 611-687 | Disordered | ||||
Sequence: NLLTTGLPSGLNPSSESSKCGSREASPVPDHKSGASQRNGSPKTTMKESINELQNIQRLVSGLESQRETSSPRDSPK | ||||||
Compositional bias | 642-679 | Polar residues | ||||
Sequence: KSGASQRNGSPKTTMKESINELQNIQRLVSGLESQRET | ||||||
Coiled coil | 654-681 | |||||
Sequence: TTMKESINELQNIQRLVSGLESQRETSS |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length687
- Mass (Da)75,335
- Last updated2010-04-20 v4
- ChecksumAC57238D05744256
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M6Z9K6 | A0A8M6Z9K6_DANRE | tbx2b | 409 |
Sequence caution
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 336-357 | Basic and acidic residues | ||||
Sequence: NRGSRDDKTCTDSEHEMDHQND | ||||||
Sequence conflict | 368 | in Ref. 1; AAF59835 | ||||
Sequence: E → K | ||||||
Compositional bias | 375-428 | Basic and acidic residues | ||||
Sequence: SRSEDWGREKPIAEKKDDYPDSRKTSDSIFSIRNLEKDKLESRSRKDTDSSKKD | ||||||
Compositional bias | 429-452 | Polar residues | ||||
Sequence: TENSGISGSKDSFSPLMVQTESPS | ||||||
Compositional bias | 611-632 | Polar residues | ||||
Sequence: NLLTTGLPSGLNPSSESSKCGS | ||||||
Compositional bias | 642-679 | Polar residues | ||||
Sequence: KSGASQRNGSPKTTMKESINELQNIQRLVSGLESQRET |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF179405 EMBL· GenBank· DDBJ | AAF59835.1 EMBL· GenBank· DDBJ | mRNA | ||
BC051603 EMBL· GenBank· DDBJ | AAH51603.2 EMBL· GenBank· DDBJ | mRNA | ||
AF136946 EMBL· GenBank· DDBJ | AAD44194.1 EMBL· GenBank· DDBJ | mRNA | Frameshift |