Q7ZTU9 · TBX2_DANRE

Function

function

Transcription factor which acts as a transcriptional repressor (By similarity).
May also function as a transcriptional activator (By similarity).
Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (By similarity).
Involved in the transcriptional regulation of genes required for mesoderm differentiation. Plays a role in the specification of late notochordal precursor cells and formation of the differentiated notochord. Required for cardiac atrioventricular canal formation

Features

Showing features for dna binding.

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TypeIDPosition(s)Description
DNA binding103-276T-box

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromatin
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processatrioventricular canal development
Biological Processaxial mesoderm development
Biological ProcessBMP signaling pathway
Biological Processbrain development
Biological Processcamera-type eye photoreceptor cell differentiation
Biological Processcardiac chamber development
Biological Processcell adhesion
Biological Processcell fate specification
Biological Processcell migration involved in gastrulation
Biological Processembryonic heart tube development
Biological Processepithalamus development
Biological Processheart looping
Biological Processhepatocyte differentiation
Biological Processlate distal convoluted tubule development
Biological Processneuron fate commitment
Biological Processnotochord development
Biological Processphotoreceptor cell development
Biological Processphotoreceptor cell fate specification
Biological Processpineal gland development
Biological Processpositive regulation of DNA-templated transcription
Biological Processpronephric distal tubule development
Biological Processpronephros development
Biological Processproximal convoluted tubule development
Biological Processregulation of heart contraction
Biological Processregulation of transcription by RNA polymerase II
Biological Processretinal cone cell development
Biological Processretinal cone cell fate commitment
Biological Processretinal cone cell fate determination
Biological Processretinal rod cell development

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    T-box transcription factor TBX2b
  • Short names
    T-box protein 2b

Gene names

    • Name
      tbx2b
    • Synonyms
      tbx-c

Organism names

  • Taxonomic identifier
  • Strain
    • SJD
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q7ZTU9
  • Secondary accessions
    • Q9IAL0
    • Q9W7B7

Proteomes

    • Identifier
    • Component
      Alternate scaffold 15, Chromosome 15

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Loss of atrioventricular canal formation and cardiac looping.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002624631-687T-box transcription factor TBX2b

Proteomic databases

Expression

Tissue specificity

Expressed in the axial mesoderm, notably, in the notochordal precursor cells immediately before formation of the notochord and in the chordoneural hinge of the tail bud, after the notochord is formed. In addition, its expression is detected in the ventral forebrain, sensory neurons, fin buds and excretory system.

Developmental stage

Expression seen in many tissues of ectodermal and mesodermal origin during embryogenesis. First detected at bud stage in the ventral prosencephalon and along the length of the notochord. As segmentation proceeds, expressed in the optic primordia, otic placodes and diffusely in cells over the yolk lying ventrally to the tail bud. Midway through the segmentation period, expression also seen in the acostic and lateral line sensory ganglia. At 22 hpf, found in the most posterior portion of the pronephric ducts (PubMed:10664151).
At the end of gastrulation, expression seen in the prospective ventral forebrain, single eye field and the presumptive notochord. At 12 hpf, expression in the midline found only at the posterior end of the notochord where it can be detected until the end of segmentation. At 20 hpf, expression in the eye is restricted to the dorsal retina and also found in the epiphysis, otic vesicles and sensory neurons of cranial ganglia. At 22 hpf, expressed in bud of pectoral fins and at 30 hpf, in a subset of interneurons in the anterior spinal cord (PubMed:10331981).

Gene expression databases

Interaction

Subunit

Binds DNA as a monomer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, coiled coil.

TypeIDPosition(s)Description
Region303-452Disordered
Compositional bias336-357Basic and acidic residues
Compositional bias375-428Basic and acidic residues
Compositional bias429-452Polar residues
Compositional bias611-632Polar residues
Region611-687Disordered
Compositional bias642-679Polar residues
Coiled coil654-681

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    687
  • Mass (Da)
    75,335
  • Last updated
    2010-04-20 v4
  • Checksum
    AC57238D05744256
MRDPVFTGTAMAYHPFHAHRPTDFPMSAFLAAAQPSFFPALTLPPGALTKPIPDHTLAGAAEAGLHPALSHHHQAAHLRSLKSLEPEEEVEDDPKVTLEAKDLWDQFHKLGTEMVITKSGRRMFPPFKVRINGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLPSLRMYEDQCKVDRDGADSDASSSEPTTGRDAGHSPGPVSSPLRFNRGSRDDKTCTDSEHEMDHQNDRCGGSSSPAPEPSSPFRSRSEDWGREKPIAEKKDDYPDSRKTSDSIFSIRNLEKDKLESRSRKDTDSSKKDTENSGISGSKDSFSPLMVQTESPSHFGAGHLQSLALSGLHSQQFFNPLNTGQPLLFHPGQFAMAPGAFSAMGMGHLLASVSGAGGLENGSLSAQGTGSTPSPFPFHLSQHMLASQGIPMPTFGGLFPYPYTYMAAAAAAASALPASSSTASSLSRNPFLSSSTRPRLRFNPYQLPVSIPQSTNLLTTGLPSGLNPSSESSKCGSREASPVPDHKSGASQRNGSPKTTMKESINELQNIQRLVSGLESQRETSSPRDSPK

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8M6Z9K6A0A8M6Z9K6_DANREtbx2b409

Sequence caution

The sequence AAD44194.1 differs from that shown. Reason: Frameshift

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias336-357Basic and acidic residues
Sequence conflict368in Ref. 1; AAF59835
Compositional bias375-428Basic and acidic residues
Compositional bias429-452Polar residues
Compositional bias611-632Polar residues
Compositional bias642-679Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF179405
EMBL· GenBank· DDBJ
AAF59835.1
EMBL· GenBank· DDBJ
mRNA
BC051603
EMBL· GenBank· DDBJ
AAH51603.2
EMBL· GenBank· DDBJ
mRNA
AF136946
EMBL· GenBank· DDBJ
AAD44194.1
EMBL· GenBank· DDBJ
mRNA Frameshift

Genome annotation databases

Similar Proteins

Disclaimer

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