Q7Z8P9 · NDK_ASPFU
- ProteinNucleoside diphosphate kinase
- Genendk1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids153 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Catalytic activity
- a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP
Cofactor
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 11 | ATP (UniProtKB | ChEBI) | |||
Binding site | 59 | ATP (UniProtKB | ChEBI) | |||
Binding site | 87 | ATP (UniProtKB | ChEBI) | |||
Binding site | 93 | ATP (UniProtKB | ChEBI) | |||
Binding site | 104 | ATP (UniProtKB | ChEBI) | |||
Binding site | 114 | ATP (UniProtKB | ChEBI) | |||
Active site | 117 | Pros-phosphohistidine intermediate | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | nucleoside diphosphate kinase activity | |
Biological Process | CTP biosynthetic process | |
Biological Process | GTP biosynthetic process | |
Biological Process | phosphorylation | |
Biological Process | UTP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNucleoside diphosphate kinase
- EC number
- Short namesNDK; NDP kinase
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Fumigati
Accessions
- Primary accessionQ7Z8P9
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000137148 | 1-153 | Nucleoside diphosphate kinase | ||
Keywords
- PTM
PTM databases
Interaction
Structure
Sequence
- Sequence statusComplete
- Length153
- Mass (Da)16,932
- Last updated2003-10-01 v1
- Checksum5432887C72096447
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY324230 EMBL· GenBank· DDBJ | AAP85295.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHF01000011 EMBL· GenBank· DDBJ | EAL85957.1 EMBL· GenBank· DDBJ | Genomic DNA |